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Sanofi-aventis Delivers 2008 Results Above Guidance
Date:2/11/2009

705 +9.9% 6,143 +15.3%

Full-year 2008 sales of Plavix(R) in the United States (consolidated by BMS) were sharply higher than in 2007, when sales were affected by competition from a generic version in the early part of the year. In Europe, the product's 3.2% growth rate reflected competition from several clopidogrel besylates in the monotherapy segment since August in Germany, where the market share of Plavix(R)/Iscover(R) by volume remained around 75% in December (IMS Pharmatrend, week commencing December 22, 2008). In the "Other Countries" region, growth for Plavix(R) benefited from its success in Japan, where net sales reached EUR 67 million in the fourth quarter of 2008 (vs. EUR 33 million in the fourth quarter of 2007) and EUR 182 million over 2008 as a whole (vs. EUR 66 million in 2007).

Worldwide presence(1) of Aprovel(R)/Avapro(R)/Karvea(R)

    EUR million                        Change on a            Change on a
                                       comparable             comparable
                                Q4 2008    basis     FY 2008     basis
    Europe                        250        +9.2%     992        +8.8%
    United States                 140        +2.2%     499        +6.4%
    Other Countries               120        +4.3%     475       +20.6%
    TOTAL                         510        +6.0%   1,966       +10.8%

Despite a very competitive environment, worldwide sales of Aprovel(R) achieved double-digit growth in 2008.

(1) See appendix 7 for a definition of financial indicators

In September 2008, the Committee for Medicinal Products for Human Use (CHMP) issued a positive opinion on the authorization of a generic of irbesartan as a monotherapy in Europe. However, the active ingredient of
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