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Sanofi-aventis Announces Good First-quarter 2009 Performance
Date:4/29/2009

benefit was seen in the reduction of stroke, by 28% (2.4% vs. 3.3% per year, p<0.001), which is the primary goal of physicians treating patients with atrial fibrillation. Filing for approval is scheduled for the third quarter of 2009.

Worldwide presence of Aprovel(R)/Avapro(R)/Karvea(R)

    euro  million                        Q1 2009        Change at
                                                         constant
                                                         exchange
                                                            rates
    Europe                                   248            +4.1%
    United States                            132            -0.8%
    Other Countries                          127           +18.5%
    TOTAL                                    507            +6.1%

Aprovel(R) reported growth of 18.5% in Other Countries region due to sales of active ingredient to our Japanese partners. In the United States, the product continued to face a highly competitive environment. In Europe, Aprovel(R) posted 4.1% growth. During the quarter, irbesartan generics began to be marketed in the monotherapy segment in Spain and Portugal. In both these countries, as well as in Finland, Norway and some Eastern European countries, irbesartan is not protected by an active ingredient patent. In the main European countries, Aprovel(R) is protected by an active ingredient patent through August 2012. Net sales of Aprovel(R) as a monotherapy in European countries with no active ingredient patent were approximately euro 50 million in 2008.

Other products

In the United States, net sales of the hypnotic Ambien(R) CR fell by 7.1% to euro 128 million. In Japan, Myslee(R), the leading hypnotic on the market, posted furt
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SOURCE Sanofi-aventis
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