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Sanofi-aventis Announces Good First-quarter 2009 Performance
Date:4/29/2009

to external R&D alliances. The following decisions have been taken:

  • In Phase III, saredutant is discontinued on the basis of results from the study in association with escitalopram in depression, AVE5530 is halted in hypercholesterolemia due to insufficient efficacy, and the rights to TroVax(R) are returned to Oxford BioMedica. As regards vaccines, resources in the intercontinental zone will be reallocated to the hexavalent vaccine Hexaxim(R) (DTP-HepB-Polio-Hib), with the Unifive(TM) pentavalent project (DTP-HepB-Hib) discontinued.
  • In Phase II, we have halted the development of AVE0657 in sleep apnea, SSR180575 in diabetic polyneuropathy, AVE1642* (an anti-IGF 1) in oncology, and the melanoma vaccine.
  • We have also halted six projects that were in Phase I.

In addition, we will decide in the next few months whether or not to continue developing four products (AVE1625, xaliprodene, idrabiotaparinux and West Nile virus vaccine), primarily on the basis of results from clinical trials currently under way.

Following this review, our portfolio now comprises 51 projects in clinical development (New Molecular entities and vaccines), of which 21 are either in Phase III or have been submitted for regulatory approval. Vaccines represent 35% of the total, other biological products 14%, and external collaborations 27%.

* Rights returned to Immunogen, Inc.

Main developments in the R&D portfolio

The main developments in our R&D portfolio in the first quarter of 2009 are described below.

  • On March 18, 2009, the FDA Advisory Committee recommended approval of Multaq(R) to treat patients with atrial fibrillation. A new drug application is currently being reviewed in the European Union. The AT
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SOURCE Sanofi-aventis
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