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Sanofi Pasteur Presents Positive Results of Tetravalent Dengue Candidate Vaccine
Date:11/6/2007

),(3) Overall, the disease is a potential threat for close to half the world's population. Dengue disease if often cyclical and causes spikes in demand on local medical resources and places tremendous pressure on strained hospitals and clinics located in endemic countries.

Dengue fever occurs mostly in tropical and subtropical countries and it is spreading to new parts of the globe each year. For example, outbreaks recently have been observed in Paraguay and the Middle East. In addition, dengue affects countries such as Australia (Queensland) and the United States (Puerto Rico, Texas-Mexico border, Hawaii and the US-affiliated Pacific Islands). A substantial number of people traveling to endemic regions are also infected each year.

Sanofi Pasteur's tetravalent dengue candidate vaccine is based on a new technology incorporating the protein envelopes that provide immunity against the four virus types responsible for dengue fever and the most severe forms of the disease-dengue hemorrhagic fever and dengue shock syndrome.

About Sanofi-aventis

Sanofi-aventis, a leading global pharmaceutical company, discovers, develops and distributes therapeutic solutions to improve the lives of everyone. Sanofi-aventis is listed in Paris (EURONEXT : SAN) and in New York (NYSE : SNY).

Sanofi Pasteur, the vaccines division of sanofi-aventis Group, provided more than a billion doses of vaccine in 2006, making it possible to immunize more than 500 million people across the globe. A world leader in the vaccine industry, Sanofi Pasteur offers the broadest range of vaccines protecting against 20 infectious diseases. The company's heritage, to create vaccines that protect life, dates back more than a century. Sanofi Pasteur is the largest company entirely dedicated to vaccines. Every day, the company invests more than EUR1 million in research and development. For more information, please visit: http://www.sanofi
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