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Sanofi Pasteur Enters Agreement With Crucell for Next-Generation Biologicals Against Rabies
Date:1/3/2008

Exclusive Agreement for Rabies Monoclonal Antibodies to Fight Fatal Disease

LYON, France, January 3 /PRNewswire-FirstCall/ -- Sanofi Pasteur, the vaccines division of sanofi-aventis Group, announced today that it has signed an exclusive collaboration and commercialization agreement with Crucell N.V. (Euronext, NASDAQ: CRXL) for Crucell's rabies monoclonal antibodies (MAbs), next-generation rabies biologicals to be used in association with rabies vaccine for post-exposure prophylaxis against this fatal disease.

Rabies causes 55,000 deaths worldwide annually, mostly in rural areas of Asia and Africa(1). Today there is no treatment for rabies once symptoms of the disease have appeared. Post exposure prophylaxis for severe bites requires both active immunization, using vaccines such as those currently marketed by sanofi pasteur, and passive immunization in the form of rabies immunoglobulins (RIG). Rabies monoclonal antibodies (MAbs) are expected to be an innovative and potent alternative to currently used RIGs.

In the last 20 years, over 20 million people in 100 countries have been treated with sanofi pasteur's rabies products.

"Sanofi pasteur is the global leader in providing rabies vaccine and immunoglobulin, and the only international company to offer a full range of rabies biologicals. Adding a next generation rabies treatment to our well-established rabies product range will further position the company as a leading force to help prevent this fatal disease," said Wayne Pisano, President and Chief Executive Officer of Sanofi Pasteur. "Louis Pasteur's first human rabies immunization in 1885 was a founding milestone for modern vaccination and we are proud to build on his legacy with innovative treatments."

Crucell has developed a combination of two rabies MAbs that has shown favorable results comparable to current immunoglobulin products in preclinical trials. Phase I clinical trials demonstrated that the MAb-based product is well
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SOURCE Sanofi Pasteur
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