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Sangamo BioSciences Reports First Quarter 2009 Financial Results
Date:4/29/2009

pared to $11.6 million for the same period in 2008.

Net interest and other income was $0.2 million for the first quarter of 2009, compared to $0.8 million for the same period in 2008. The decrease was due to lower average investment balances and lower interest rates.

First Quarter 2009 Highlights

  • Sangamo and its collaborators at the University of Pennsylvania opened a Phase 1 clinical trial to evaluate SB-728-T for the treatment of HIV/AIDS. The study is an open-label Phase 1 clinical trial designed to evaluate the safety and tolerability of a single infusion of SB-728-T, autologous (a patient's own) CD4+ T cells genetically modified at the CCR5 gene by CCR5-specific zinc finger DNA-binding protein nucleases (ZFNs). A total of twelve subjects with HIV will be enrolled in this trial in two treatment cohorts. In an animal model of HIV infection, SB-728-T has been shown to lead to an increase in CD4+ T-cell counts, a reduction in viral load and expansion of CCR5-modified T-cells, suggesting resistance to HIV. CCR5 is a co-receptor that enables HIV to enter and infect cells of the immune system. Individuals carrying a natural mutation of their CCR5 gene, CCR5-delta32, are highly resistant to infection by HIV. Brief exposure of cells to Sangamo's ZFNs results in the permanent disruption of the CCR5 gene. This trial is the first zinc finger nuclease therapeutic study in humans. Individuals interested in participating in this trial should visit http://www.clinicaltrials.gov/
  • Sangamo BioSciences, Inc. and its plant agriculture partner Dow AgroSciences announce publication in Nature of the successful application of ZFP technology for the efficient generation of maize plants with multiple, commercia
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SOURCE Sangamo BioSciences, Inc.
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