Navigation Links
Sangamo BioSciences Announces Presentation of Top-Line Statistically Significant Phase 2 Data in Diabetic Neuropathy at Society for Neuroscience Meeting
Date:10/20/2009

pratt(3), D. Ando(3), G. Lee(3), R. Surosky(3), M. G. Fehlings(2); (1) Univ. of Toronto, Toronto, ON, Canada; (2) Genet. and Develop., Univ. Hlth. Network, Toronto, ON, Canada; (3) Sangamo BioSciences, Inc., Richmond, CA

Researchers observed that in an animal model of spinal cord injury, 24 hour delayed administration of a ZFP TF that upregulates VEGF-A (a form of SB-509) decreased the degradation of NF200, a marker of cell injury, decreased apoptosis or cell death of nerve cells in and around the spinal cord and enhanced new blood vessel growth around the injured cord.

About SB-509

SB-509 is an injectable plasmid encoding a DNA-binding Zinc Finger DNA-binding Protein (ZFP) transcription factor (ZFP TF) designed to upregulate the endogenous expression of the gene encoding vascular endothelial growth factor (VEGF-A). VEGF-A has been demonstrated to have direct angiogenic, neurotrophic and neuroprotective properties. In preclinical animal efficacy studies in a diabetic rat model (Diabetes, June 1, 2006; 55(6): 1847-1854), SB-509 has proven effective in protecting motor and sensory nerve function from disease-induced nerve damage.

About Diabetic Neuropathy

Diabetic neuropathy is a progressive degenerative disease that is one of the most frequent complications of diabetes, affecting between 14 and 16.5 million Americans in 2007. High blood glucose levels lead to nerve damage over time, primarily affecting peripheral nerves. Symptoms include numbness, tingling sensations and pain particularly in the toes or feet, which gradually evolve to loss of sensation and motor function as nerve damage progresses. Ulcers and sores may appear on numb areas of the foot as pressure wounds or injuries go unnoticed. Despite palliative treatment, these areas of trauma frequently become infected and this infection may spread to the bone, necessitating amputation of the leg or foot. More than 60 pe
'/>"/>

SOURCE Sangamo BioSciences, Inc.
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7 8

Related medicine news :

1. Sangamo BioSciences Presents Positive Phase 2 ZFP Therapeutic Data at ADA 2009
2. Sangamo BioSciences Announces Presentation at the JMP Securities Research Conference
3. Sangamo BioSciences Reports First Quarter 2009 Financial Results
4. Sangamo BioSciences Provides Update on Companys Accomplishments in 2007 and 2008 Objectives
5. Sangamo BioSciences to Present at the ThinkEquity Partners Growth Conference
6. Magellan Biosciences Sells its Life Sciences Tools Business to Dionex
7. Regado Biosciences Announces First Patient Enrolled in RADAR (Phase 2b) Study of REG1 Anticoagulation System
8. Neurocrine Biosciences to Present at the Thomas Weisel Partners Healthcare Conference
9. Cell Biosciences Launches Unique Protein Phosphorylation Assay Service
10. Sartorius Stedim Biotech Partners With Cell Culture Media Specialist SAFC Biosciences(R) to Provide World-Class Fluid Management and Liquid/Powder System Solutions
11. Catalyst Biosciences Announces Agreement With MedImmune to Discover and Develop Engineered Protease Therapeutics
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/29/2015)... New York, NY (PRWEB) May 29, 2015 ... Pharmaceuticals unit have reached a confidential Risperdal lawsuit ... who allegedly developed gynecomastia due to his use ... the case had been selected for the third ... in a mass tort litigation underway in Pennsylvania’s ...
(Date:5/29/2015)... Inspire Nexus, a new social network officially ... question many life coaches have asked, "How do I ... necessary to become a credentialed Coach?" , Many Life ... for long. Inspire Nexus, a social network for Coaches ... who have experience coaching a certain number of hours, ...
(Date:5/29/2015)... Chicago, Ill (PRWEB) May 29, 2015 ... Care , a dozen medical pioneers recognized by a ... changed the course of cancer treatment. Honorees will be ... of Cancer Care™ Award Ceremony, held 8:30-11:00 p.m. CDT ... , The 2015 honorees are being recognized for groundbreaking ...
(Date:5/29/2015)... 2015 The Global Allopurinol Industry ... on the current state of the Allopurinol industry.With ... statistics on the state of the industry and ... for companies and individuals interested in the market. ... industry including definitions, classifications, applications and industry chain ...
(Date:5/29/2015)... May 29, 2015 Healthpointe’s electromyography ... to the Los Angeles County clinics including its ... are now being offered at all Healthpointe locations ... and San Bernardino County. , As the ... send electrical impulses throughout the body and ...
Breaking Medicine News(10 mins):Health News:Risperdal Lawsuit Selected as Pennsylvania’s Third Bellwether Gynecomastia Case Settles Hours Before Trial 2Health News:Risperdal Lawsuit Selected as Pennsylvania’s Third Bellwether Gynecomastia Case Settles Hours Before Trial 3Health News:OncLive's 2015 Giants of Cancer Care™ Awards Announced Today 2Health News:OncLive's 2015 Giants of Cancer Care™ Awards Announced Today 3Health News:OncLive's 2015 Giants of Cancer Care™ Awards Announced Today 4Health News:Allopurinol Industry (Global, China) 2015 Research Analysis and 2020 Forecasts 2Health News:Healthpointe Is Now Offering EMG and NCV Diagnostics at All Clinics throughout Southern California. 2
... a scientist with Lawson Health Research Institute in London, Ontario ... North America and around the world. Matic has been ... gum tissue of cleft palate patients. His research suggests that ... , Matic is a craniofacial/plastic surgeon at London Health Sciences ...
... 750,000, mostly males, are hooked , , MONDAY, May 12 ... young adults are problem gamblers according to researchers at ... , Problem gambling is defined as gambling associated with ... than you intended or stealing money to gamble. , ...
... May 12 OmniSonics Medical,Technologies, Inc., a developer ... of vascular disease, announced today that it has ... SONIC II is a prospective,multi-center U.S. registry study ... undergoing percutaneous mechanical thrombectomy,for acute limb ischemia (ALI). ...
... Naturlose, a natural sugar,approved as a food ingredient in ... of serum glucose that follow consumption of food (1). In,a ... is currently,studying the efficacy and safety of Naturlose for the ... has engaged market,research companies to seek feedback as to the ...
... Reporters/Editors/Producers , RE: American Psychological Association 116th Annual Convention ... Room 162A, Meeting Level 1, Boston Convention and Exhibition ... lap tops and two high-speed printers. We will also ... data transmission and APA staff resources. This room will ...
... Joel Ario today announced that the Insurance Department ... the state to,hear from consumers and other affected ... and Independence Blue Cross, plus related,changes, will impact ... held July 8 in Pittsburgh, July 10 in ...
Cached Medicine News:Health News:Research shows timing improves cleft palate surgery 2Health News:Problem Gambling Common Among Young Adults 2Health News:OmniSonics Medical Technologies Announces First Patient Enrolled in SONIC II REGISTRY 2Health News:Market Research Shows Spherix's Naturlose(R) Readily Accepted by Diabetes Patients 2Health News:Market Research Shows Spherix's Naturlose(R) Readily Accepted by Diabetes Patients 3Health News:Highlights for APA's 116th Annual Convention in Boston, Aug. 14-17 2Health News:Highlights for APA's 116th Annual Convention in Boston, Aug. 14-17 3Health News:Highlights for APA's 116th Annual Convention in Boston, Aug. 14-17 4Health News:Insurance Department to Hold Statewide Meetings on Proposed Consolidation of Independence Blue Cross, Highmark 2
(Date:5/29/2015)... 28, 2015 Research and Markets ( http://www.researchandmarkets.com/research/64lx2w/north_america_mri ... America MRI Market - Growth, Trends And Forecasts (2014 ... The North American MRI systems market is estimated to ... $1.58 billion by 2020 with a CAGR of 2.9% ... types namely, the open system, closed system and the ...
(Date:5/29/2015)... DUBLIN , May 28, 2015 Research ... of the "North America Open System MRI Market ... report to their offering. The key players ... , Philips Healthcare, Siemens Healthcare and Toshiba Medical Systems ... tool which is replacing CT because of its higher ...
(Date:5/29/2015)... , May 29, 2015  The annual customer satisfaction ... ranks Praxis EMR as #1 across all specialties. Every ... Research LLC conducts a poll of EHR users and ... results.    Praxis EMR topped 348 ... 18 performance based criteria used by Black Book. In ...
Breaking Medicine Technology:North America MRI Market - Growth, Trends And Forecasts 2014-2019 with GE, Hitachi Medical, Philips Healthcare, Siemens Healthcare & Toshiba Medical Systems Dominating 2North America Open System MRI Market 2014-2019 with GE, Hitachi Medical, Philips Healthcare, Siemens Healthcare and Toshiba Medical Dominating 2Praxis EMR Ranks #1 for Physician Satisfaction in Black Book's 2015 Survey of Solo and Small Practices 2
... RDEA594 Data to Be Presented at the 2008 Annual European Congress of, Rheumatology ... Phase 1 Human Study of RDEA594 Planned in Second Half of ... ... Biosciences, Inc.,(Nasdaq: RDEA ) today announced the identification of its lead development,candidate ...
... filing anticipated in 1Q 2009 -, PRINCETON, ... ) has nominated PSI-7851 as a lead development ... (HCV). PSI-7851 is a proprietary,nucleotide analogue polymerase inhibitor ... Practice (GLP) animal toxicity studies required for,submission of ...
Cached Medicine Technology:Ardea Biosciences Identifies Lead Development Candidate for Gout, RDEA594 2Ardea Biosciences Identifies Lead Development Candidate for Gout, RDEA594 3Ardea Biosciences Identifies Lead Development Candidate for Gout, RDEA594 4Ardea Biosciences Identifies Lead Development Candidate for Gout, RDEA594 5Pharmasset Nominates PSI-7851 as a Lead Development Candidate for the Treatment of Chronic Hepatitis C 2Pharmasset Nominates PSI-7851 as a Lead Development Candidate for the Treatment of Chronic Hepatitis C 3
Bravo pH Receiver. For ambulatory 24/48 hour pH recordings using catheter-free radio-telemetry capsule. Features up to two channels. AA Batteries included....
Bravo Vacuum Pump Accessories Kit (One canister, one lid, one "O" ring tube, one tubing set)...
... esophhageal sphincter (LES) can be ... separate manometry system. pH catheters ... accessory kit and Digitrapper pH ... the LES. The kit and ...
pHix Strips easily fix the catheter on the nose and are made of microporous tape allowing the skin to breathe....
Medicine Products: