Navigation Links
Sangamo BioSciences Announces Presentation of Top-Line Statistically Significant Phase 2 Data in Diabetic Neuropathy at Society for Neuroscience Meeting
Date:10/20/2009

pratt(3), D. Ando(3), G. Lee(3), R. Surosky(3), M. G. Fehlings(2); (1) Univ. of Toronto, Toronto, ON, Canada; (2) Genet. and Develop., Univ. Hlth. Network, Toronto, ON, Canada; (3) Sangamo BioSciences, Inc., Richmond, CA

Researchers observed that in an animal model of spinal cord injury, 24 hour delayed administration of a ZFP TF that upregulates VEGF-A (a form of SB-509) decreased the degradation of NF200, a marker of cell injury, decreased apoptosis or cell death of nerve cells in and around the spinal cord and enhanced new blood vessel growth around the injured cord.

About SB-509

SB-509 is an injectable plasmid encoding a DNA-binding Zinc Finger DNA-binding Protein (ZFP) transcription factor (ZFP TF) designed to upregulate the endogenous expression of the gene encoding vascular endothelial growth factor (VEGF-A). VEGF-A has been demonstrated to have direct angiogenic, neurotrophic and neuroprotective properties. In preclinical animal efficacy studies in a diabetic rat model (Diabetes, June 1, 2006; 55(6): 1847-1854), SB-509 has proven effective in protecting motor and sensory nerve function from disease-induced nerve damage.

About Diabetic Neuropathy

Diabetic neuropathy is a progressive degenerative disease that is one of the most frequent complications of diabetes, affecting between 14 and 16.5 million Americans in 2007. High blood glucose levels lead to nerve damage over time, primarily affecting peripheral nerves. Symptoms include numbness, tingling sensations and pain particularly in the toes or feet, which gradually evolve to loss of sensation and motor function as nerve damage progresses. Ulcers and sores may appear on numb areas of the foot as pressure wounds or injuries go unnoticed. Despite palliative treatment, these areas of trauma frequently become infected and this infection may spread to the bone, necessitating amputation of the leg or foot. More than 60 pe
'/>"/>

SOURCE Sangamo BioSciences, Inc.
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7 8

Related medicine news :

1. Sangamo BioSciences Presents Positive Phase 2 ZFP Therapeutic Data at ADA 2009
2. Sangamo BioSciences Announces Presentation at the JMP Securities Research Conference
3. Sangamo BioSciences Reports First Quarter 2009 Financial Results
4. Sangamo BioSciences Provides Update on Companys Accomplishments in 2007 and 2008 Objectives
5. Sangamo BioSciences to Present at the ThinkEquity Partners Growth Conference
6. Magellan Biosciences Sells its Life Sciences Tools Business to Dionex
7. Regado Biosciences Announces First Patient Enrolled in RADAR (Phase 2b) Study of REG1 Anticoagulation System
8. Neurocrine Biosciences to Present at the Thomas Weisel Partners Healthcare Conference
9. Cell Biosciences Launches Unique Protein Phosphorylation Assay Service
10. Sartorius Stedim Biotech Partners With Cell Culture Media Specialist SAFC Biosciences(R) to Provide World-Class Fluid Management and Liquid/Powder System Solutions
11. Catalyst Biosciences Announces Agreement With MedImmune to Discover and Develop Engineered Protease Therapeutics
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/23/2014)... By Kathleen Doheny ... -- For babies born at very low birth weights, breast ... to a potentially dangerous infection known as cytomegalovirus (CMV), a ... very low birth weight infants -- all of whom weighed ... mothers with a history of CMV infection, to see whether ...
(Date:9/23/2014)... Sept. 23, 2014 (HealthDay News) -- Both drinking and ... factors for alcohol abuse by high school students, a ... survey of high school students who drink, could help ... who already drink, to stop them from becoming binge ... between age of first alcohol use and progression to ...
(Date:9/23/2014)... September 23, 2014 What information ... The National Quality Forum (NQF) released a report ... ), and an infographic ( http://bit.ly/1tX3lzA ) resulting ... of healthcare, how patients define affordability, and what ... get the best possible healthcare at the lowest ...
(Date:9/23/2014)... News) -- Few children who take medication for ... the rates vary six-fold across counties in the ... alone can manage symptoms for many children with ... receive behavioral therapy (psychotherapy), the Rand Corp. researchers ... than 1,500 counties across the United States that ...
(Date:9/23/2014)... obese as teenagers could grow up to earn up ... weight. So says Petter Lundborg of Lund University, Paul ... University and Lund University, all in Sweden. The team ... the United States, and the results are published in ... analyzed large-scale data of 145,193 Swedish-born brothers who enlisted ...
Breaking Medicine News(10 mins):Health News:Breast Milk a Risk for Spreading Common Virus to Preemies, Study Finds 2Health News:Breast Milk a Risk for Spreading Common Virus to Preemies, Study Finds 3Health News:Younger Age at First Drink, Higher Odds for Problem Drinking: Study 2Health News:Younger Age at First Drink, Higher Odds for Problem Drinking: Study 3Health News:Finding Affordable Care: Asking the Right Question is Key 2Health News:Kids Taking ADHD Drugs Get Little Psychotherapy: Study 2Health News:Note to young men: Fat doesn't pay 2
... satellite imagery also provides crash data in public policy effort ... You can now find the deadliest road in your town ... program that aims to increase public awareness of the need ... Minnesota,s Center for Excellence in Rural Safety (CERS) developed www.saferoadmaps.org, ...
... in the developing world may have substantially underestimated ... findings suggest that policymakers in low-income and middle-income ... impact that dementia places on their health services. ... population increases, dementia and other age-related illnesses are ...
... July 26 The following is a,transcript of the radio ... Good morning. This week, Congress voted to expand a,vital program ... Plan for AIDS Relief, also known as PEPFAR. I thank ... with my Administration to,pass this important bill, and I will ...
... being,issued by the Democratic National Committee:, (Logo: ... of the National Council on Disabilities, and,Bob Kafka, ... today in,advance of John McCain,s appearance via satellite ... Ohio. There is speculation that Senator,McCain will follow ...
... discuss second quarter financial results -, LAVAL, QC, ... today announced that it will host a conference call ... its second quarter 2008,financial results. Labopharm will report its ... 7:00 a.m. the same day., To access the ...
... immune response after antiretroviral therapy may be due to ... A new study challenges the long-held belief that the ... to restore itself after HIV patients are treated with ... to 90 percent of HIV-infected drug users are also ...
Cached Medicine News:Health News:Researchers Map America's Deadliest Roads 2Health News:Prevalence of dementia in the developing world underestimated 2Health News:Prevalence of dementia in the developing world underestimated 3Health News:Radio Address by President Bush to the Nation 2Health News:Radio Address by President Bush to the Nation 3Health News:AUDIO OF CONFERENCE CALL: National Disability Rights Leaders Dubious Over John McCain's Possible Switch on Community Choice Act, Says DNC 2Health News:Labopharm to host conference call Friday, August 8, 2008 at 8:30 A.M. (ET) 2Health News:Study Disproves Belief That Hepatitis C Blunts HIV Drugs 2
(Date:9/23/2014)... , Sept. 23, 2014 Research and ... (HbA1c) Testing Market" report to their offering. ... rate across the globe. Over 382 million people are estimated ... likely to increase to 592 million by 2035. With ... China and India ...
(Date:9/23/2014)... 2014 The Pennsylvania State Police will accept unwanted, ... part of National Prescription Drug Take-Back Day. The service ... Take-Back Day is a national initiative, conducted in partnership ... encouraging the public to dispose of expired, unused or ... theft. From 10 a.m. to 2 p.m., ...
(Date:9/23/2014)... September 23, 2014 ... the addition of the  "Large Volume Wearable ... offering.  ,     (Logo: http://photos.prnewswire.com/prnh/20130307/600769) ... market holds significant potential for the future. ... painful needles to the modern-day pre-filled syringes, ...
Breaking Medicine Technology:Glycated Haemoglobin (HbA1c) Testing Market 2Glycated Haemoglobin (HbA1c) Testing Market 3Large Volume Wearable Injectors - 2nd Edition 2Large Volume Wearable Injectors - 2nd Edition 3Large Volume Wearable Injectors - 2nd Edition 4Large Volume Wearable Injectors - 2nd Edition 5
... N.J., Sept. 13, 2011 BD (Becton, Dickinson and ... medical technology company, today announced a commitment to Pink ... and private investments in global health to combat cervical ... Institute, the President,s Emergency Plan for AIDS Relief (PEPFAR), ...
... Calif., Sept. 13, 2011 BioMarin Pharmaceutical Inc. (Nasdaq: ... Officer of BioMarin, will present a company update at the ... September 20, 2011 at 12:30 p.m. ET.   ... conference call via the investor section of the BioMarin website, ...
Cached Medicine Technology:BD to Increase Access to Vital Cervical Cancer Screening in Resource-Limited Settings Through Commitment to Pink Ribbon Red Ribbon Initiative® 2BD to Increase Access to Vital Cervical Cancer Screening in Resource-Limited Settings Through Commitment to Pink Ribbon Red Ribbon Initiative® 3BD to Increase Access to Vital Cervical Cancer Screening in Resource-Limited Settings Through Commitment to Pink Ribbon Red Ribbon Initiative® 4BioMarin to Present at the UBS Global Life Sciences Conference 2
... and Cronin, Inc. is ... Patient Footwear, Orthopedic Softgoods, ... Products. Our products are ... and available in the ...
Perfect for use in the E.R. Stabilizes collateral ligament strains in seconds and allows hand and finger function. Made from 1/8" AliPlast™ PXE. Can be scissor trimmed....
... Control of thumb motion can be difficult ... for persons with spinal cord injuries and ... to cerebral palsy or other motor or ... the thumb for control and coordination. Soft ...
... Splints offer support without the restriction of ... pain or strain due to repetitive stress ... rigid or the flexible stay to provide ... and breathable, the ThumWrap Splint is comfortable ...
Medicine Products: