Navigation Links
Sangamo BioSciences Announces Presentation of Top-Line Statistically Significant Phase 2 Data in Diabetic Neuropathy at Society for Neuroscience Meeting
Date:10/20/2009

id in the development of future clinical studies. We are grateful to the Juvenile Diabetes Research Foundation for their support and funding of our studies using this promising endpoint."

Details of Presentation of IENFD Data from SB-509-601 Study

Tuesday, October 20, 2009

  • "Epidermal nerve fiber density and regeneration with vascular endothelial growth factor zinc finger protein activator (SB-509) in mild to moderate diabetic peripheral neuropathy patients. (SB-509-0601 study)." M. Polydefkis(1), P. Haurei(1), *E. Benaim(2), D. Ando(2), S. Hamilton(2), H. Kim(2), S. Study Group(2); (1) Johns Hopkins Univ., Baltimore, MD; (2) Clin. Affairs, Sangamo BioSciences, Richmond, CA

IENFD and IENFD Regrowth (IENFDR) measurements were prospectively defined endpoints in Sangamo's double-blind, repeat dosing Phase 2 clinical study (SB-509-601) in which subjects were treated at 0, 60 and 120 days. Evaluation of SB-509 treatment on IENFD and IENFDR was carried out in collaboration with Michael Polydefkis, M.D., Associate Professor of Neurology, Johns Hopkins University Medical School and funded by a grant from the Juvenile Diabetes Research Foundation (JDRF).

IENFD derived from 3mm skin punch biopsies taken from the thigh at baseline (Day 0) and thirty days after the final treatment (Day 150) were obtained from both SB-509 and placebo treated subjects. In addition, IENFDR was determined by applying a capsaicin patch to the skin of the thigh to produce a standardized nerve injury on Days 150 and 151 and using serial skin biopsies over time, post capsaicin treatment, up to Day 360, to determine nerve regrowth in both SB-509 and placebo-treated subjects.

In SB-509 treated subjects an increase in mean change in nerve fiber density from baseline was observed compared to a decrease for placebo treated subjects (p-value = 0.02). Importantly, a rank sum analysis of these data
'/>"/>

SOURCE Sangamo BioSciences, Inc.
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7 8

Related medicine news :

1. Sangamo BioSciences Presents Positive Phase 2 ZFP Therapeutic Data at ADA 2009
2. Sangamo BioSciences Announces Presentation at the JMP Securities Research Conference
3. Sangamo BioSciences Reports First Quarter 2009 Financial Results
4. Sangamo BioSciences Provides Update on Companys Accomplishments in 2007 and 2008 Objectives
5. Sangamo BioSciences to Present at the ThinkEquity Partners Growth Conference
6. Magellan Biosciences Sells its Life Sciences Tools Business to Dionex
7. Regado Biosciences Announces First Patient Enrolled in RADAR (Phase 2b) Study of REG1 Anticoagulation System
8. Neurocrine Biosciences to Present at the Thomas Weisel Partners Healthcare Conference
9. Cell Biosciences Launches Unique Protein Phosphorylation Assay Service
10. Sartorius Stedim Biotech Partners With Cell Culture Media Specialist SAFC Biosciences(R) to Provide World-Class Fluid Management and Liquid/Powder System Solutions
11. Catalyst Biosciences Announces Agreement With MedImmune to Discover and Develop Engineered Protease Therapeutics
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/20/2014)... The excitement is building up once again for ... This year the Surry Arts Council will be celebrating its ... country who are still fans of the Andy Griffith Show. ... aired on CBS from 1960 through 1968. The show ranked ... history. Mount Airy, North Carolina is where the show was ...
(Date:9/20/2014)... 20, 2014 Earlier this week, Home Depot ... have had their credit card information pilfered by hackers, surpassing ... slew of headline articles like this one published ... eye opening numbers. , “Most people tend to focus ... it’s a way to score a game,” says Joe Caruso, ...
(Date:9/20/2014)... September 20, 2014 The first federal ... now in its third week in the U.S. District ... reports. Court documents indicate that the week opened in ... testimony from a DePuy Orthopaedics vice president, who discussed ... the company’s Pinnacle hip replacement. According to Reuters, the ...
(Date:9/19/2014)... NY (PRWEB) September 20, 2014 ... revenue growth for the Vision Insurance industry in ... to the detriment of industry margins. From 2009 ... increase. Industry operators provide coverage for routine eye ... pricing for eyeglasses, contact lens and refractive surgery. ...
(Date:9/19/2014)... -- As kids transition from elementary to middle school, ... a recent study. But the researchers studying ... verbal and physical bullying declines as students get older. ... strategies must address all types of bullying as well ... researchers said. The study was published recently in ...
Breaking Medicine News(10 mins):Health News:Mayberry Days Parade Cars will be Provided by Mount Airy Toyota and Mount Airy Chrysler Dodge Jeep Ram 2Health News:Don’t Let Data Breach Fatigue Cause Dangerous Cyber Security Complacency 2Health News:Don’t Let Data Breach Fatigue Cause Dangerous Cyber Security Complacency 3Health News:Don’t Let Data Breach Fatigue Cause Dangerous Cyber Security Complacency 4Health News:Don’t Let Data Breach Fatigue Cause Dangerous Cyber Security Complacency 5Health News:Third Week of DePuy Pinnacle Hip Lawsuit Trial Focuses on Clinical Testing of Metal-on-Metal Hip Implant, Wright & Schulte LLC Reports 2Health News:Third Week of DePuy Pinnacle Hip Lawsuit Trial Focuses on Clinical Testing of Metal-on-Metal Hip Implant, Wright & Schulte LLC Reports 3Health News:Third Week of DePuy Pinnacle Hip Lawsuit Trial Focuses on Clinical Testing of Metal-on-Metal Hip Implant, Wright & Schulte LLC Reports 4Health News:Vision Insurance in the US Industry Market Research Report from IBISWorld Has Been Updated 2Health News:Vision Insurance in the US Industry Market Research Report from IBISWorld Has Been Updated 3Health News:Vision Insurance in the US Industry Market Research Report from IBISWorld Has Been Updated 4Health News: Cyberbullying Seems to Ramp Up in Middle School 2
... should be the imaging test of choice when evaluating patients ... ankle and toes causing uncontrolled slapping of the foot while ... at the ARRS 2010 Annual Meeting in San Diego, CA. ... body to high-frequency ultrasound waves to produce pictures of inside ...
... diagnose muscular trauma in professional athletes on-site, which helps them ... enough to take them out of the game, according to ... Meeting in San Diego, CA. "Muscular trauma is very ... MD, lead author of the study. "Ultrasound is a readily ...
... ... Recently Hosted their 5th Annual Spring Luncheon for the Elder Care Community at Wesley Homes in ... the Senior Services Meals on Wheels Program, and Provided an Opportunity for Elder Care Providers in ... ...
... ... 6-12, , ... May 6, 2010 -- HealthCareerWeb.com, a division of Dominion Enterprises, is recognizing the efforts ... Week, May 6th through May 12th. Nurses and/or those who appreciate nursing professionals are ...
... ... year with the City of Laguna Hills Memorial Day Half Marathon and ... bring out more than 6,000 runners, walkers, spectators, and volunteers to the ... is available online at www.lagunahillshalfmarathon.com . You can also register ...
... ... businessman from Prior Lake, Minnesota, plans to do 200 skydives on Wednesday, June 16, 2010! ... educate people about Parkinson’s Disease. , ... (PRWEB) May 6, 2010 -- No one has to tell Kevin Burkart to ...
Cached Medicine News:Health News:The SASH Program Hosts 5th Annual Springtime Luncheon for Elder Care Community 2Health News:The SASH Program Hosts 5th Annual Springtime Luncheon for Elder Care Community 3Health News:HealthCareerWeb.com "Appreciates Nurses A Latte" 2Health News:City of Laguna Hills Announces Memorial Day Half Marathon and 5K 2Health News:Help Minnesota Man Reach His Goal of Raising Money & Awareness Sponsor 1 of his “200 Perfect Jumps for Parkinson's Disease" 2
(Date:9/19/2014)... 19, 2014  The board of directors of AbbVie ... cash dividend of $0.42 per share.  ... stockholders of record at the close of business on ... a global, research-based biopharmaceutical company formed in 2013 following ... its expertise, dedicated people and unique approach to innovation ...
(Date:9/19/2014)... STATION, N.J. , Sept. 19, 2014 Merck (NYSE: ... United States and Canada , is ... Desafiando La Diabetes: Logra Tus Metas , an educational program ... their blood sugar -- a key treatment goal to help reduce ... United States are at a higher risk for developing ...
(Date:9/19/2014)... Larry J. Merlo , President and CEO ... before the National Press Club in Washington, D.C. ... to stop selling tobacco products and its leadership in driving ... "Dramatic changes in our health care system pose enormous ... has said. "CVS Health has a truly unique combination of ...
Breaking Medicine Technology:Celebrity Chef Leticia Moreinos Schwartz Partners with Merck on Desafiando La Diabetes: Logra Tus Metas to Urge Hispanics With Type 2 Diabetes to Get to Their A1C Goal 2Celebrity Chef Leticia Moreinos Schwartz Partners with Merck on Desafiando La Diabetes: Logra Tus Metas to Urge Hispanics With Type 2 Diabetes to Get to Their A1C Goal 3Celebrity Chef Leticia Moreinos Schwartz Partners with Merck on Desafiando La Diabetes: Logra Tus Metas to Urge Hispanics With Type 2 Diabetes to Get to Their A1C Goal 4Celebrity Chef Leticia Moreinos Schwartz Partners with Merck on Desafiando La Diabetes: Logra Tus Metas to Urge Hispanics With Type 2 Diabetes to Get to Their A1C Goal 5CVS Health CEO to Address National Press Club on Landmark Decision to Quit Tobacco, Leadership in Health Care Innovation 2CVS Health CEO to Address National Press Club on Landmark Decision to Quit Tobacco, Leadership in Health Care Innovation 3
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
Medicine Products: