Navigation Links
Sanford-Burnham's Erkki Ruoslahti named to Thomson Reuters' Nobel Prize watch list
Date:9/20/2012

LA JOLLA, Calif., September 20, 2012 Thomson Reuters has selected Erkki Ruoslahti, M.D., Ph.D., cancer researcher and distinguished professor at Sanford-Burnham Medical Research Institute (Sanford-Burnham), as one of its 2012 Citation Laureates. Citation Laureates are scientists that Thomson Reuters has predicted to win the Nobel Prize.

Thomson Reuters Citation Laureates are chosen based on how frequently their research has been cited by other researchers. Many studies have shown a strong correlation between citations and regard by one's peers, a factor often reflected in major professional awards. Using this quantitative approach, Thomson Reuters has made many correct predictions; in the past 10 years, 26 Citation Laureates received Nobel Prizes. The 2012 Nobel Prize recipients will be announced beginning October 8.

Ruoslahti is among the 50 most-cited researchers of the last 20 years and an influential figure in cell biology and cancer research. He was one of the early pioneers in research on cell adhesionthe study of how cells stay in place by sticking to one another and to their surrounding environments. Ruoslahti's work has clarified many of the fundamental mechanisms responsible for clinically relevant problems, including blood clotting, immune cell homing, and tumor metastasis. His research spawned many drug-discovery programs around the world aimed at finding new treatments for arterial restenosis, thrombosis, cancer, and moresome of which have resulted in FDA-approved drugs.

In addition to his research, Ruoslahti distinguished himself through the leadership and vision he provided during his 13 years as president and chief executive officer of Sanford-Burnham Medical Research Institute (1989-2002). Under his direction, Sanford-Burnham's National Cancer Institute (NCI)-designated Cancer Center became one of the leading basic cancer research centers in the world.

"Dr. Ruoslahti's seminal research has made outstanding and vitally important contributions to the study of cancer and other diseases that will serve medicine well into the future," said Kristiina Vuori, M.D., Ph.D., who completed her postdoctoral training under Ruoslahti's mentorship and now serves as Sanford-Burnham's president and director of the Institute's NCI-designated Cancer Center. "It is testimony to Dr. Ruoslahti's special talents that he has been able to perform cutting-edge research, while running and building a world-class research Institutean accomplishment matched by few individuals. He is most deserving of the honor of being named Thomson Reuters Citation Laureate."

From basic biology to nanotechnology

In the early 1970s, Ruoslahti co-discovered fibronectin, one of the first known extracellular matrix proteins, a family of proteins that make up connective tissues and influence cellular growth, movement, and communication. Ruoslahti then pinpointed the short region of the fibronectin protein and other adhesive proteins that allows them to attach to cellsa string of just three amino acids known as RGD. He and his team also isolated the proteins on cell surfaces that bind fibronectin via RGD. These receptors later became known as integrins.

As a result of Ruoslahti's work, two FDA-approved drugs based on RGD have come to the market. By inhibiting integrin activity with RGD mimics, these therapies prevent reoccurrence of blocked blood vessels following angioplasty, a procedure to widen arteries obstructed by cholesterol and inflammation (atherosclerosis). A number of additional RGD-based therapeutic drugs are currently in clinical trials for cancer.

Ruoslahti also pioneered the opposite approachtaking advantage of RGD's affinity for integrins instead of blocking it. He and his team coupled anti-cancer drugs to RGD and other short proteins that specifically home to "vascular zip codes," markers unique to the blood vessels that feed tumors. They've found that adding these homing peptides to current anti-cancer drugs increases potency and reduces toxicity. Extensive efforts are underway to develop RGD-based drugs that suppress new tumor blood vessel growth and block metastasis.

In addition, Ruoslahti's team is now using RGD and similar homing peptides to deliver nanoparticles specifically to tumors, in order to boost current anti-cancer therapies.

"It's now clear that interactions between cells and the extracellular matrix that surrounds them play major roles in cell and developmental biology," said Ruoslahti. "I'm proud of our contributions to this field and grateful for the opportunity to see our work make a difference in the treatment of patients."

Other accomplishments and honors

Ruoslahti received his Ph.D. and M.D. from the University of Helsinki in Finland and conducted his postdoctoral research at the California Institute of Technology. He joined Sanford-Burnham's faculty in 1979 and served as the Institute's president from 1989-2002. He is currently a distinguished professor at Sanford-Burnham and an adjunct distinguished professor at the University of California, Santa Barbara.

Ruoslahti is a member of the U.S. National Academy of Sciences, the Institute of Medicine, the American Academy of Arts and Sciences, and the European Molecular Biology Organization. He is the recipient of the G.H.A. Clowes Award, Robert J. and Claire Pasarow Foundation Award, Jacobaeus International Prize, and The Jubilee Award given by the British Biomedical Society. He was a Nobel Fellow at the Karolinska Institute in Stockholm in 1995 and is a Knight of the Order of the White Rose of Finland.

In 2005, Ruoslahti was honored with a Japan Prize, one of the world's major awards for contributions to progress in science and technology and advancement of world peace and prosperity.


'/>"/>

Contact: Heather Buschman, Ph.D.
hbuschman@sanfordburnham.org
858-795-5343
Sanford-Burnham Medical Research Institute
Source:Eurekalert  

Related medicine news :

1. Edith Mitchell, M.D., FACP, named 2012 recipient of ASCO Humanitarian Award
2. Dr. William Oh named 2012 Legend of Neonatology
3. UCSC physicist Alexander Sher named Pew Scholar in the Biomedical Sciences
4. Old Bridge Sleep Center Named to Best of 2012 List
5. UMMS researcher Victor Ambros, Ph.D., named co-recipient of 2012 Janssen Award for Biomedical Research
6. Pittsburgh Cardiologist Named Physician of the Year by Pulmonary Hypertension Association
7. IVR Technology Group Named Platimum VAR by TSYS
8. New coral reef crustacean described and named after late reggae performer Bob Marley
9. UT Southwestern named the official health care team of the Dallas Stars
10. IHME professor named first health measurement winner of prestigious innovation award
11. College biology faculty named Leadership Fellows
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Sanford-Burnham's Erkki Ruoslahti named to Thomson Reuters' Nobel Prize watch list
(Date:6/25/2016)... TX (PRWEB) , ... June 25, 2016 , ... ... the United States, named Dr. Sesan Ogunleye, as the Medical Director of its new ... the facility Medical Director of our new Mesquite location,” said Dr. James M. Muzzarelli, ...
(Date:6/25/2016)... ... June 25, 2016 , ... Conventional wisdom preaches the benefits ... terms of the latter, setting the bar too high can result in disappointment, perhaps ... slow progress toward their goal. , Research from PsychTests.com reveals that ...
(Date:6/24/2016)... ... June 24, 2016 , ... Marcy was in a crisis. Her son James, eight, ... at his family verbally and physically. , “When something upset him, he couldn’t control his ... it. He would throw rocks at my other children and say he was going to ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... Comfort Keepers® ... American Cancer Society and the Road To Recovery® program to drive cancer patients to ... and other adults to ensure the highest quality of life and ongoing independence. ...
(Date:6/24/2016)... ... June 24, 2016 , ... ... to recognize Dr. Barry M. Weintraub as a prominent plastic surgeon and the ... in the world, and the most handsome men, look naturally attractive. Plastic surgery ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... , June 27, 2016  VMS Rehab Systems, ... Board will take whatever measures required to build a ... stock which is currently listed on the OTC Markets-pink ... Company Chairman and CEO, "We are seeing an anomaly ... to understand, not only by the Company, but shareholders ...
(Date:6/24/2016)... 24, 2016  Global Blood Therapeutics, Inc. (GBT) (NASDAQ: ... novel therapeutics for the treatment of grievous blood-based ... closing of its previously announced underwritten public offering ... public offering price of $18.75 per share. All ... by GBT. GBT estimates net proceeds from the ...
(Date:6/24/2016)... ALEXANDRIA, Va. , June 24, 2016 ... a set of recommendations that would allow ... information (HCEI) with entities that make formulary and coverage ... determine the "value" of new medicines. The ... that does not appear on the drug label, a ...
Breaking Medicine Technology: