Navigation Links
Sanford-Burnham scientists unravel cancer drug's secret to resistance
Date:3/19/2012

LA JOLLA, Calif., March 19, 2012 Drug resistance is a serious problem for cancer patientsover time, a therapy that was once providing some benefit simply stops working. Scientists at Sanford-Burnham Medical Research Institute (Sanford-Burnham) recently discovered how cancer cells develop resistance to a drug called MLN4924. This experimental therapy is currently being tested in a number of Phase I and Phase I/II clinical trials to determine its efficacy against several different types of cancer, including multiple myeloma, leukemia, and lymphoma.

Published online March 19 by Cell Reports, the study shows that MLN4924-resistant cancer cells escape death because they have a simple mutation in the drug's targetNEDD8-activating enzymethat prevents the drug from binding. In unraveling this mechanism, the researchers also developed a relatively quick, low-cost laboratory method that can be used to personalize cancer therapies by predicting how cancer patients will respond to this or other drugsall before a person starts taking it.

"Due to genetic variability, some tumors might be more prone to developing resistance to treatment than others. Pinpointing the right treatment for an individual can be a frustrating and costly trial-and-error process. The method we developed in this study to determine the mechanism of resistance for one anti-cancer drug gives us a jumpstart on knowing if this resistance mechanism will hold true for other drugspotentially saving time and money," said Matthew Petroski, Ph.D., assistant professor in Sanford-Burnham's National Cancer Institute-designated Cancer Center and senior author of the study.

MLN4924: Promising anti-cancer drug

MLN4924 kills most cancer cells by binding and inactivating the NEDD8-activating enzyme. NEDD8 and the enzymes that control it are part of the ubiquitin proteasome system (so-named because it's ubiquitous, found in every cell in the body).

This comp
'/>"/>

Contact: Heather Buschman, Ph.D.
hbuschman@sanfordburnham.org
858-795-5343
Sanford-Burnham Medical Research Institute
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Sanford-Burnham research advances to patient studies at TRI
2. Sanford-Burnham and Florida Hospital review obesity research progress with Takeda Pharmaceutical
3. Moffitt, Sanford-Burnham and Florida Hospital create Personalized Medicine Partnership of Florida
4. Sanford-Burnham researchers find molecular switch that allows melanoma to resist therapy
5. Scripps Health and Sanford-Burnham to collaborate to advance new cancer treatments
6. Dr. Kristiina Vuori Promoted to President of Sanford-Burnham Medical Research Institute
7. Dana-Farber and Sanford-Burnham Institute license flu-targeting antibodies to Genentech and Roche
8. Scientists develop a software tool for estimating heart disease risk
9. UCLA scientists uncover mechanism for melanoma drug resistance
10. No workout? No worries: Scientists prevent muscle loss in mice, despite disease and inactivity
11. New test can better predict successful IVF embryos, scientists say
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Sanford-Burnham scientists unravel cancer drug's secret to resistance
(Date:3/28/2015)... March 28, 2015 Early surgery may ... Type V AC joint injuries, according to new research ... at the American Orthopaedic Society for Sports Medicine’s ( ... duty faster when surgery was not performed. , The ... receiving surgical treatment and 17 receiving non-surgical therapy. Of ...
(Date:3/28/2015)... San Francisco, California (PRWEB) March 28, 2015 ... search for original 1960's Who psychedelic concert posters. The Who ... Flushing, New York on August 2, 1968. According to Hawley, ... 1969 playing many concert halls and college campuses. Perhaps the ... their performance with Jim Morrison and the Doors on August ...
(Date:3/28/2015)... 28, 2015 Aureus Medical Group ... including physical therapy jobs, has announced that it ... Physical Therapy Association Annual Conference to be held ... Hotel in Columbus, OH. , The OPTA ... exhibits with products and services. , Representatives ...
(Date:3/28/2015)... The "Petrick Sustainable Health System" ... After 18 years of research and experience with patients ... Dr. Jon Petrick is excited to be launching his ... the immediate benefits of this radical new system are ... strength of the immune system, faster healing of injuries, ...
(Date:3/28/2015)... March 28, 2015 ARDX will sponsor the ... 12pm -3pm at the Chesapeake Conference Center in Chesapeake, Virginia. ... an empowering event for women in the Hampton Roads region. ... Stories of Women’s Lives. Women grow stronger through sharing ... other. This year the WWC™ theme is T-talk where ...
Breaking Medicine News(10 mins):Health News:For Type V AC Joint Injuries, Early Surgery May Not Be the Best Approach 2Health News:Avid Collector from Vintage Rock Posters, Inc. Announces His Search For Original 1960's Who Psychedelic Concert Posters. 2Health News:Healthcare Staffing Leader, Aureus Medical Group, to Exhibit at the Ohio Physical Therapy Association Annual Conference 2Health News:Celebrity Chiropractor Jon Petrick to Release Sustainable Health System this Summer 2
... Consensus Guideline Reached For Quantitative Polymerase Chain ReactionSALT LAKE ... and the American Association for Clinical ... guideline for a key laboratory method called qPCR (or ... of international scientists representing the medical and research fields. ...
... AdCare Health Systems, Inc. (NYSE AMEX: ADK ... and management company today reported financial results for its ... December 31, 2008 were $24,793,294 as compared to $23,667,756 ... The improvement was primarily due to increased rental charges ...
... alerting capabilities, delivering meaningful performance measurements and relevant operational data ... ... Plano, TX (PRWEB) March 31, 2009 -- ... - Corepoint Decisions . Corepoint Health,s latest product ...
... 31 Hanger Orthopedic Group, Inc. (NYSE: HGR ) ... operations for the first quarter ended March 31, 2009, on ... release announcing the results for the first quarter ended March ... of the market. The conference call is scheduled to begin ...
... provider of advanced, high-volume, document and payment processing ... signed an exclusive service provider agreement with iVu ... early detection of cancer and other disease states. ... BancTec,s growing Multi-Vendor Services Group."BancTec,s Multi-Vendor Services Group ...
... League biologist who researches viruses to determine how and why ... of Houston April 2. The lecture is free and ... University associate professor of ecology and evolutionary biology, will speak ... the Science and Engineering Classroom Building Auditorium. His talk ...
Cached Medicine News:Health News:International Scientists Secure Quality in Molecular Diagnostics 2Health News:International Scientists Secure Quality in Molecular Diagnostics 3Health News:AdCare Health Systems, Inc. Reports Financial Results for 2008 2Health News:AdCare Health Systems, Inc. Reports Financial Results for 2008 3Health News:AdCare Health Systems, Inc. Reports Financial Results for 2008 4Health News:AdCare Health Systems, Inc. Reports Financial Results for 2008 5Health News:AdCare Health Systems, Inc. Reports Financial Results for 2008 6Health News:AdCare Health Systems, Inc. Reports Financial Results for 2008 7Health News:AdCare Health Systems, Inc. Reports Financial Results for 2008 8Health News:AdCare Health Systems, Inc. Reports Financial Results for 2008 9Health News:Corepoint Health Launches New Product Suite Focused on Enhancing Healthcare Operations & Metrics 2Health News:Corepoint Health Launches New Product Suite Focused on Enhancing Healthcare Operations & Metrics 3Health News:Corepoint Health Launches New Product Suite Focused on Enhancing Healthcare Operations & Metrics 4Health News:Hanger Orthopedic Group, Inc. Announces First Quarter 2009 Earnings Release Conference Call 2Health News:iVu Imaging Selects BancTec's Multi-Vendor Services Group as Exclusive Service Provider for Intelligent Volumetric Ultrasound Equipment 2Health News:iVu Imaging Selects BancTec's Multi-Vendor Services Group as Exclusive Service Provider for Intelligent Volumetric Ultrasound Equipment 3Health News:Virus evolution topic of Darwin talk at UH April 2 2
(Date:3/27/2015)... , March 27, 2015 Across the global ... meeting challenges in clinical development, market education, and regulatory ... the Medical Affairs function is expected to increase in ... According to research by benchmarking firm, ... a group dedicated to Medical Affairs. Among companies in ...
(Date:3/27/2015)... , March 27, 2015 /PRNewswire/ - Medicure Inc. (the ... Directors has approved the grant of an aggregate of ... employees and consultants of the Company pursuant to the ... set to expire on the tenth anniversary of the ... the third anniversary of the date of grant and ...
(Date:3/27/2015)... VICTORIA, Texas , March 27, 2015  Victoria Vein ... removal services with the Astanza Duality laser in ... of vein disease as well as advanced laser treatments for ... are entering the tattoo industry to provide more services for ... Surgery has helped many Victoria residents ...
Breaking Medicine Technology:Medical Affairs Capabilities Expanding in Emerging Marketplaces 2Victoria Vein And Surgery Clinic Uses Advanced Astanza Duality Tattoo Removal Technology 2
... Sept. 27, 2011 Masimo ... that findings from a new study published in the ... noninvasive and continuous hemoglobin (SpHb®) monitoring has absolute and ... hemoglobin measurement with additional advantages.  Study highlights that "the ...
... the United States Food and Drug Administration ("FDA") said its ... fold increase risk of blood clots for women who use ... The safety of Yaz and Yasmin is the subject ... of Common Pleas Judge Sandra Mazer Moss, Coordinating Judge of ...
Cached Medicine Technology:Published Study Demonstrates the Absolute and Trend Accuracy of Masimo Noninvasive and Continuous Total Hemoglobin (SpHb) Monitoring in Intensive Care Unit Patients 2Published Study Demonstrates the Absolute and Trend Accuracy of Masimo Noninvasive and Continuous Total Hemoglobin (SpHb) Monitoring in Intensive Care Unit Patients 3Published Study Demonstrates the Absolute and Trend Accuracy of Masimo Noninvasive and Continuous Total Hemoglobin (SpHb) Monitoring in Intensive Care Unit Patients 4Published Study Demonstrates the Absolute and Trend Accuracy of Masimo Noninvasive and Continuous Total Hemoglobin (SpHb) Monitoring in Intensive Care Unit Patients 5Published Study Demonstrates the Absolute and Trend Accuracy of Masimo Noninvasive and Continuous Total Hemoglobin (SpHb) Monitoring in Intensive Care Unit Patients 6FDA Issues Safety Communication Regarding Increased Risk of Blood Clots with Certain Birth Control Pills 2
For the qualitative detection of single and multiple drugs and drug metabolites in human urine...
For the qualitative detection of single and multiple drugs and drug metabolites in human urine...
For the qualitative detection of single and multiple drugs and drug metabolites in human urine...
For the qualitative detection of single and multiple drugs and drug metabolites in human urine...
Medicine Products: