Navigation Links
Sanford-Burnham scientists unravel cancer drug's secret to resistance
Date:3/19/2012

LA JOLLA, Calif., March 19, 2012 Drug resistance is a serious problem for cancer patientsover time, a therapy that was once providing some benefit simply stops working. Scientists at Sanford-Burnham Medical Research Institute (Sanford-Burnham) recently discovered how cancer cells develop resistance to a drug called MLN4924. This experimental therapy is currently being tested in a number of Phase I and Phase I/II clinical trials to determine its efficacy against several different types of cancer, including multiple myeloma, leukemia, and lymphoma.

Published online March 19 by Cell Reports, the study shows that MLN4924-resistant cancer cells escape death because they have a simple mutation in the drug's targetNEDD8-activating enzymethat prevents the drug from binding. In unraveling this mechanism, the researchers also developed a relatively quick, low-cost laboratory method that can be used to personalize cancer therapies by predicting how cancer patients will respond to this or other drugsall before a person starts taking it.

"Due to genetic variability, some tumors might be more prone to developing resistance to treatment than others. Pinpointing the right treatment for an individual can be a frustrating and costly trial-and-error process. The method we developed in this study to determine the mechanism of resistance for one anti-cancer drug gives us a jumpstart on knowing if this resistance mechanism will hold true for other drugspotentially saving time and money," said Matthew Petroski, Ph.D., assistant professor in Sanford-Burnham's National Cancer Institute-designated Cancer Center and senior author of the study.

MLN4924: Promising anti-cancer drug

MLN4924 kills most cancer cells by binding and inactivating the NEDD8-activating enzyme. NEDD8 and the enzymes that control it are part of the ubiquitin proteasome system (so-named because it's ubiquitous, found in every cell in the body).

This comp
'/>"/>

Contact: Heather Buschman, Ph.D.
hbuschman@sanfordburnham.org
858-795-5343
Sanford-Burnham Medical Research Institute
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Sanford-Burnham research advances to patient studies at TRI
2. Sanford-Burnham and Florida Hospital review obesity research progress with Takeda Pharmaceutical
3. Moffitt, Sanford-Burnham and Florida Hospital create Personalized Medicine Partnership of Florida
4. Sanford-Burnham researchers find molecular switch that allows melanoma to resist therapy
5. Scripps Health and Sanford-Burnham to collaborate to advance new cancer treatments
6. Dr. Kristiina Vuori Promoted to President of Sanford-Burnham Medical Research Institute
7. Dana-Farber and Sanford-Burnham Institute license flu-targeting antibodies to Genentech and Roche
8. Scientists develop a software tool for estimating heart disease risk
9. UCLA scientists uncover mechanism for melanoma drug resistance
10. No workout? No worries: Scientists prevent muscle loss in mice, despite disease and inactivity
11. New test can better predict successful IVF embryos, scientists say
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Sanford-Burnham scientists unravel cancer drug's secret to resistance
(Date:3/2/2015)... 02, 2015 The Alliance for Bangladesh ... expert Mark Chubb to serve as chief safety officer. ... and training in Bangladesh and guide remediation efforts in ... “Mark will ensure that the Alliance continues to bring ... for Bangladesh garment workers,” said Alliance Independent Chair Ellen ...
(Date:3/2/2015)... ProvidaStaff has announced today that ... division to EDU Healthcare to reflect better ... systems and students nationwide. , “ProvidaStaff has always been ... the country,” said Angela M. Lewis, President of ProvidaStaff. ... and the introduction of EDU Healthcare better aligns our ...
(Date:3/2/2015)... Viejo, California (PRWEB) March 02, 2015 ... release of the TranStatic Volume 2 from Pixel Film Studios. ... transitions made exclusively for FCPX,” said Christina Austin, CEO of ... to have in any Final Cut Pro X editors toolbox.” ... scene to the next with media altering static scrambling effects ...
(Date:3/1/2015)... 2015 To help healthcare ... their practices compliantly and profitably, MDreferralPRO and ... The interoperability between a strategic referral ... practice management system is necessary for a ... A referral management and development solution relies ...
(Date:3/1/2015)... As residents and business owners in ... and Carita Weaver, believe in supporting local organizations ... Southlake Chamber of Commerce, Carroll Independent School District ... a website for Southlake mayoral candidate Laura Hill: ... for Hill’s campaign, the website combines images, videos ...
Breaking Medicine News(10 mins):Health News:Alliance for Bangladesh Worker Safety Names New Chief Safety Officer 2Health News:ProvidaStaff Announces New Name Change to EDU Healthcare for Its Educational Healthcare Division 2Health News:ProvidaStaff Announces New Name Change to EDU Healthcare for Its Educational Healthcare Division 3Health News:Pixel Film Studios released the TranStatic Volume 2 plugin for Final Cut Pro X today 2Health News:Power Up Physician and Patient Referral Management While Qualifying for ARRA Incentives 2Health News:Power Up Physician and Patient Referral Management While Qualifying for ARRA Incentives 3Health News:Power Up Physician and Patient Referral Management While Qualifying for ARRA Incentives 4Health News:Website Launched for Southlake, Texas Mayoral Candidate Laura Hill 2
... revealed that vaccines that contain mercury do not ... Center scientists examined patterns between the developmental disorder ... findings in the journal Pediatrics. ,Their ... in children given shots after thimerosal, a mercury-based ...
... has laid unbelievable blunders on the table which speaks of ... just escaped by the skin of their teeth//. ,There ... simply unable to fathom the losses for which they are ... to a million ,The slip ups range from ...
... named menin – involved in tumor-suppression or cell-proliferation-suppressing function ... again affected blood sugar// regulation - researchers at the ... ,In humans menin gene (Men1) mutation can lead to ... (MEN1) and this discovery also has implications for diabetes ...
... been improvements in maternity care, specifically to section 88 ... to which expectant mothers prefer care of midwives over ... go far enough in bringing pregnant women back to ... the New Zealand Medical Association's GP council, said "They ...
... Medicine and Lucile Packard Children’s Hospital claim that they ... Down syndrome, in a gene that causes neurons in ... memory. ,The researchers in US have explained ... that, if over-produced, could cause certain brain cells to ...
... Robert Wood Johnson Medical School in New Brunswick, New ... likely to indulge in bed wetting //as children since ... ,"There is biological plausibility in inferring that breast-feeding protects ... association,” the researchers said. They added that there was ...
Cached Medicine News:Health News:Menin Gene Mutation made Insulin Secreting Cells to Proliferate 2Health News:Stanford Researchers Identify A Gene Causing Downs Syndrome 2
(Date:3/1/2015)... , March 1, 2015  Patients suffering from ... against this debilitating foot ailment, according to research ... ,s Annual Scientific Meeting . Researchers utilized ... emulsify and remove diseased fasciitis tissue. Permanently removing ... to regrow in its place, restoring normal function. ...
(Date:2/27/2015)... 27, 2015 Pharmaceutical and biotech marketers are ... for the same indication. This can be a complex ... prevent one of their brands from gaining market share ... recent research by benchmarking firm, Best Practices, LLC, 75% ... rather than together as part of a franchise. Marketers ...
(Date:2/27/2015)... NEW YORK , Feb. 27, 2015  Pomerantz ... Vitae Pharmaceuticals, Inc. ("Vitae" or the "Company") (NASDAQ: ... Robert S. Willoughby at rswilloughby@pomlaw.com ... whether Vitae and certain of its officers and/or directors ... Exchange Act of 1934.  On February ...
Breaking Medicine Technology:Interventional radiology treatment relieves chronic plantar fasciitis 2Interventional radiology treatment relieves chronic plantar fasciitis 3New Report Details How to Expand a Pharmaceutical Product Portfolio without Cannibalizing an Established Brand 2SHAREHOLDER ALERT: Pomerantz Law Firm Investigates Claims On Behalf of Investors of Vitae Pharmaceuticals, Inc. - VTAE 2
... ,, HARBIN, China , July ... the "Company"), a,developer, manufacturer and distributor of botanical products,bio-pharmaceuticals and traditional ... common stock on the NYSE Amex. , ... Renhuang expects to ...
... 1 Hanger Orthopedic Group, Inc. was recently ... the January 12th earthquake in Haiti ... development and humanitarian nongovernmental organizations.  Presented with InterAction,s Corporate ... by Physicians for Peace, an InterAction member organization and ...
Cached Medicine Technology:Renhuang Pharmaceuticals Receives Approval to List on the NYSE Amex 2Renhuang Pharmaceuticals Receives Approval to List on the NYSE Amex 3Hanger Orthopedic Group Honored for its Charitable Relief Efforts in Haiti by InterAction 2Hanger Orthopedic Group Honored for its Charitable Relief Efforts in Haiti by InterAction 3
Our high quality therapeutic drug monitoring reagents, calibrators and controls are available for most chemistry analyzers. Reproducible and accurate results for your laboratory needs....
The Emit 2000 Digoxin Assay is a homogeneous enzyme immunoassay intended for use in the quantitative analysis of digoxin in human serum or plasma. Emit 2000 assays are designed for use with most chem...
The Emit 2000 Digoxin Calibrators are intended for use with the Emit 2000 Digoxin Assay....
... At Akers, our ultimate goal is ... early detection and immediate treatment. Each year ... suffer and die from late detection or ... lives and cripple nations., ,By developing, manufacturing ...
Medicine Products: