Navigation Links
Sanford-Burnham researchers develop novel nanoparticle to deliver powerful RNA interference drugs
Date:7/9/2013

LA JOLLA, Calif., July 8 2013 Silencing genes that have malfunctioned is an important approach for treating diseases such as cancer and heart disease. One effective approach is to deliver drugs made from small molecules of ribonucleic acid, or RNA, which are used to inhibit gene expression. The drugs, in essence, mimic a natural process called RNA interference.

In a new paper appearing today online in the journal, ACS Medicinal Chemistry Letters, researchers at Sanford-Burnham Medical Research Institute have developed nanoparticles that appear to solve a big challenge in delivering the RNA molecules, called small interfering RNA, or siRNA, to the cells where they are needed. By synthesizing a nanoparticle that releases its siRNA cargo only after it enters targeted cells, Dr. Tariq M. Rana and colleagues showed in mice that they could deliver drugs that silenced the genes they wanted.

"Our study describes a strategy to reduce toxic effects of nanoparticles, and deliver a cargo to its target," said Dr. Rana, whose paper, "In Vivo Delivery of RNAi by Reducible Interfering Nanoparticles (iNOPs)," also included contributions from researchers at the University of Massachusetts Medical School and the University of California at San Diego. "We've found a way to release the siRNA compounds, so it can be more effective where it's needed," Dr. Rana said.

In their experiment, the team synthesized what they call interfering nanoparticles, or iNOPs, made from repetitively branched molecules of a small natural polymer called poly-L-lysine. The iNOPs were specially designed with positively charged residues connected by disulfide bonds and these iNOPS assemble into a complex with negatively charged siRNA molecules. It's the bonds that ensure that the siRNA molecules remain with the nanoparticle, named iNOP-7DS. However, once inside targeted cells, a naturally occurring and abundant antioxidant called glutathione breaks the bond, releasing the
'/>"/>

Contact: Deborah Robison
drobison@sanfordburnham.org
407-615-0072
Sanford-Burnham Medical Research Institute
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Sanford-Burnham collaborates with 5 Florida-based research organizations
2. Sanford-Burnhams Erkki Ruoslahti named to Thomson Reuters Nobel Prize watch list
3. Researchers investigate mechanism of Alzheimers therapy
4. Researchers pinpoint sources of fibrosis-promoting cells that ravage organs
5. Researchers use immunocytochemistry to determine ALK status
6. Researchers find 2 new methods to determine ALK status
7. CWRU researchers trace inner-city womens health issues to childhood traumas
8. Penn Medicine researchers discover link between fear and sound perception
9. UCI researchers awarded $2.27 million to create novel diabetes treatments
10. MS researchers determine that brain reserve independently protects against cognitive decline in MS
11. Notre Dame and Harper researchers developing novel method to test for HPV and oral cancers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/20/2014)... Lifeinsurancequoteterm.net has released a new blog ... life insurance plan provides for vulnerable family members. ... be a top priority for every provider. It is ... medical examinations and visiting a doctor. , Life ... provide coverage up to $300,000, but only to healthy ...
(Date:9/20/2014)... 2014 Ticket Down is a ... for her 2015 “Honeymoon Tour.” This well-known ticket exchange ... savings. , In early 2015, fans will have a chance ... across North America. Twenty-one-year-old Ariana Grande will hit the road ... her to 25 cities across the United States and Canada. ...
(Date:9/20/2014)... Recently, Best Cheap Hosting USA (best-cheap-hosting-usa.com), ... new website. The new site provides the latest ... for customers. Here, people can find a lot ... Also, it has recommended some excellent web hosting ... the great web hosting suppliers, InMotion ( http://www.best-cheap-hosting-usa.com/go/InMotion/ ...
(Date:9/20/2014)... (PRWEB) September 20, 2014 Recently, UWDress.com, ... dresses and women’s special occasion outfits, has launched a ... The company’s prom outfits are popular among worldwide clients. ... get wholesale prom dresses on its website. ... for customers from around the world. Great custom made ...
(Date:9/20/2014)... 2014 RBSEO Services, which has occupied ... has announced it provides an affordable website SEO (Search ... This announcement would benefit those new and old businesses ... cannot afford to pay a big amount for their ... their websites in top search results for their business ...
Breaking Medicine News(10 mins):Health News:No Medical Exam Life Insurance Provides Financial Protection for Families 2Health News:Ariana Grande Tickets in New York, Philadelphia, Orlando, Fairfax, Worcester, Toronto, Uncasville, Detroit, Miami, Pittsburgh, Cleveland, and Atlanta On Sale Today 2Health News:Ariana Grande Tickets in New York, Philadelphia, Orlando, Fairfax, Worcester, Toronto, Uncasville, Detroit, Miami, Pittsburgh, Cleveland, and Atlanta On Sale Today 3Health News:Best Cheap Hosting USA Launches Its New Website And Recommends InMotion To Worldwide People 2Health News:Discounted 2014 Prom Dresses Provided By Innovative Company UWDress.com 2Health News:RBSEO Services Announces Affordable Website SEO Service at Only $175 2
... Technologies Corp. ( www.harvesttech.com ) announced today ... first thirty (30) patients in the clinical trial of ... advanced thromboangitis obliterans, commonly referred to as Buerger,s Disease. ... University in Chennai India and is designed to evaluate ...
... and Only Once-weekly, Self-administered Alternative to Injections for ... 1 Strativa Pharmaceuticals, the proprietary products division ... Companies, Inc. (NYSE: PRX ), today ... Nascobal(R) (Cyanocobalamin, USP) Nasal Spray from QOL Medical ...
... /PRNewswire-FirstCall/ -- DaVita Inc. ... nation,s leading providers of kidney care for those ... to launch Lifestyle Management Programs for teammates ... weight management.(Logo: http://www.newscom.com/cgi-bin/prnh/20020729/DAVITALOGO )DaVita,s Village Vitality, a ...
... Corporation (OTC Bulletin Board: CHRX, CHRXU, CHRXW) (the "Company"), ... that it was in technical violation of three financial ... December 31, 2008. Chem Rx continues to ... than as to certain default interest). The covenants ...
... and PolyScript(R) Labels Enable Fast and Cost-Effective CustomizationSOUTHFIELD, Mich., ... solutions manufactured specifically to provide equipment with safety warnings ... order to help engineering industries meet the exacting demands ... PreScript (R) and PolyScript ...
... released today by the American Health Information Management ... Reporters, Editors, Publications, Washington, D.C. News Bureaus, Washington ... Management Association (AHIMA) WHAT: 2009 ICD-10 ... April 16-17, 2009 WHERE: ...
Cached Medicine News:Health News:Harvest Technologies Announces Interim Study Results From Critical Limb Ischemia Trial in Chennai India 2Health News:Harvest Technologies Announces Interim Study Results From Critical Limb Ischemia Trial in Chennai India 3Health News:Strativa Pharmaceuticals Acquires Worldwide Rights to Nascobal(R) (Cyanocobalamin, USP) Nasal Spray From QOL Medical 2Health News:Strativa Pharmaceuticals Acquires Worldwide Rights to Nascobal(R) (Cyanocobalamin, USP) Nasal Spray From QOL Medical 3Health News:Strativa Pharmaceuticals Acquires Worldwide Rights to Nascobal(R) (Cyanocobalamin, USP) Nasal Spray From QOL Medical 4Health News:DaVita's Customized Lifestyle Management Programs Assist Employees to Meet Their Lifestyle Goals 2Health News:Chem Rx Corporation in Technical Violation of Three Financial Debt Covenants 2Health News:Chem Rx Corporation in Technical Violation of Three Financial Debt Covenants 3Health News:Schreiner ProTech Introduces Intelligent Marking Solutions Achieving Process and Cost Optimizations 2
(Date:9/19/2014)... 19, 2014  Today DePuy Synthes Companies of ... plating systems featuring its proprietary variable angle locking ... trajectory to match patient anatomy and fracture pattern ... The systems are being introduced in conjunction with ... and the International Federation of Foot & Ankle ...
(Date:9/19/2014)... , Sept. 19, 2014 The Parenteral Drug ... harmonize global post-approval changes protocols. The ... the topic expressed by industry participants and regulatory authority ... this month in Washington, DC . ... on hand for the workshop. Attendees indicated openness to ...
(Date:9/19/2014)... Today, iHealth Lab Inc. announced it has secured ... its first institutional round of funding. The strategic investment ... accelerate growth and innovation, and invest in additional sales ... Ventures will join iHealth,s board of directors, bringing added ... "We are very pleased to have Xiaomi ...
Breaking Medicine Technology:DePuy Synthes Proprietary Variable Angle Locking Technology Now Available To Treat Calcaneal Fractures And Medial Column Fusion Procedures 2DePuy Synthes Proprietary Variable Angle Locking Technology Now Available To Treat Calcaneal Fractures And Medial Column Fusion Procedures 3PDA Launches Effort to Harmonize Global Post-Approval Changes Protocols 2iHealth Raises $25 Million to Fuel Growth and Global Market Share 2
... PARK, N.C. & GENEVA--(BUSINESS WIRE)--Jul 11,2007 ... research and,development program for Plasmin (Human), ... this week at the XXIst International,Society ... in Geneva,Switzerland. The information included new ...
... 2007 /PRNewswire-USNewswire/ -- After a,first childhood urinary tract ... infection, and may actually increase,the risk that the ... according to a new study in the July ... Association. , In the first large study of ...
Cached Medicine Technology:New Information on the Potential of Plasmin Shared at ISTH Congress 2New Information on the Potential of Plasmin Shared at ISTH Congress 3New Information on the Potential of Plasmin Shared at ISTH Congress 4Antibiotics Don't Prevent Future Urinary Tract Infections, May,Cause Resistance in Future Infections 2Antibiotics Don't Prevent Future Urinary Tract Infections, May,Cause Resistance in Future Infections 3
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
Medicine Products: