Navigation Links
Sanford-Burnham research advances to patient studies at TRI
Date:3/6/2012

ge numbers of brown fat cells. By finding a way to activate brown fat in adults, calories, which otherwise would be stored as unwanted white fat, can be burned. Orexin deficiency is associated with obesity in both animals and humans, while high orexin levels correlate with leanness.

"Advancing this orexin research to the TRI is a crucial first step in translating fundamental research at Sanford-Burnham to the clinical phase," said Steven Smith, M.D., scientific director of the TRI and co-director of translational research for Sanford-Burnham's Diabetes and Obesity Research Center. "At the TRI we will conduct proof-of-concept experiments to validate this new drug target and begin to test it for safety and efficacy."

So far, orexin has only been tested in mouse models, where it has been shown to reduce fat by 50 percent, even under conditions of caloric excess. The fat loss is due to an elevation in the metabolic rate. During the study at the TRI, scientists will conduct clinical testing to assess orexin's mode of action, efficacy, and how it works in the human body, as well as evaluate the hormone's acute effect in stimulating energy expenditure.

When it opens in March 2012, the TRI's new 54,000 sq. ft. facility in Orlando, Florida, will contain a research clinic, imaging technology, a biorepository for sample collection and storage, as well as several other resources for metabolic studies. But the facility's highlight will be the calorimeter rooms - small dormitory-style rooms that will allow TRI staff to measure fat and carbohydrate oxidation and energy expenditure as a person goes about his or her normal life. To make the best use of the generated data, the TRI is also building a superior informatics platform to collect and analyze their own research data, as well as personal and sample information for thousands of Florida Hospital patients. This database will help TRI, Florida Hospital and Sanford-Burnham scientists to better correlate
'/>"/>

Contact: Deborah Robison
drobison@sanfordburnham.org
407-745-2073
Sanford-Burnham Medical Research Institute
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Sanford-Burnham and Florida Hospital review obesity research progress with Takeda Pharmaceutical
2. Moffitt, Sanford-Burnham and Florida Hospital create Personalized Medicine Partnership of Florida
3. Sanford-Burnham researchers find molecular switch that allows melanoma to resist therapy
4. Scripps Health and Sanford-Burnham to collaborate to advance new cancer treatments
5. Dr. Kristiina Vuori Promoted to President of Sanford-Burnham Medical Research Institute
6. Dana-Farber and Sanford-Burnham Institute license flu-targeting antibodies to Genentech and Roche
7. Chinese Minister of Health to hold US meeting to improve cancer research collaboration
8. Researchers ID gene behind primary cervical dystonia, a neck-twisting disorder
9. Notre Dames Bengal Bouts participants aid in concussion research
10. NIH asthma outcome measures aim to maximize research investments, reduce disparities
11. Standardized outcome measures proposed for asthma clinical research
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/27/2015)... (PRWEB) , ... August 28, 2015 , ... This new ... ensure that patients are always scheduled for the next visit, their authorizations are in ... here . , According to Jason Barnes, COO for Genesis Chiropractic Software, growing a ...
(Date:8/27/2015)... Mesa, CA (PRWEB) , ... August 27, 2015 , ... ... to get help, leaving weeks or months later, relapsing and returning again, all at ... under the influence while in sober living homes or soon after leaving facilities who ...
(Date:8/27/2015)... Los Angeles, CA (PRWEB) , ... August 27, 2015 , ... ... Diabetes Association and the American Heart Association have released new guidelines to educate doctors ... that the last update to these particular guidelines came in 2007, so the new ...
(Date:8/27/2015)... ... 27, 2015 , ... In mid-May, Logistics Trust, Inc. (“Logistics ... launch of its Doobster platform, a HIPAA-compliant mobile application that allows medical marijuana ... phones and tablets. Well, Doobster, “The App That Delivers!” is here! ...
(Date:8/27/2015)... ... August 27, 2015 , ... The Naderi Center is proud to announce ... cutting-edge, noninvasive procedure to improve submental fat. The first and only Food and ... surgery. Dr. Kulak is the only Board Certified surgeon in the D.C., Maryland, ...
Breaking Medicine News(10 mins):Health News:A New Webinar Teaches Chiropractors How to Use Compliance Alerts to Manage Patient Relationships 2Health News:National Screenings of Documentary Indicate Burgeoning Questions about the Effectiveness of Addiction Treatment Facilities 2Health News:National Screenings of Documentary Indicate Burgeoning Questions about the Effectiveness of Addiction Treatment Facilities 3Health News:Article on New Diabetic Care Guidelines Shines Brightly on Weight Loss Surgery, notes Beverly Hills Physicians 2Health News:Article on New Diabetic Care Guidelines Shines Brightly on Weight Loss Surgery, notes Beverly Hills Physicians 3Health News:Doobster Launches a Nationwide, Comprehensive On-Demand Medical Marijuana App 2Health News:Doobster Launches a Nationwide, Comprehensive On-Demand Medical Marijuana App 3Health News:Doobster Launches a Nationwide, Comprehensive On-Demand Medical Marijuana App 4Health News:Doobster Launches a Nationwide, Comprehensive On-Demand Medical Marijuana App 5Health News:Noninvasive Double Chin Elimination Now Available in Herndon and Chevy Chase 2Health News:Noninvasive Double Chin Elimination Now Available in Herndon and Chevy Chase 3
... medical records to be provided at locations throughout ... entered into a clinical collaboration with MinuteClinic, the ... in the United States, at several locations inside ... provide a convenient, seven-day-a-week option for those with ...
... eminent orthopaedic surgeon at the University of Brighton Medical School has ... research on a new orthopaedic prosthesis for shoulder reconstruction. , ... ... Keith Borowsky, an eminent orthopaedic surgeon at the University of Brighton ...
... Court for the Commonwealth of MassachusettsVANCOUVER, Feb. 12 ... ; TSX: QLT) announced that on February 11, ... Massachusetts General Hospital ("MGH"), filed a complaint in ... against QLT Phototherapeutics (Canada), Inc. QLT Phototherapeutics (Canada), ...
... gender also affect chances of having debilitating headaches , , THURSDAY, ... risk of migraine headaches in young and middle-aged adults, suggests ... gender and the way body fat was distributed affected migraine ... were more likely to have migraines than those with smaller ...
... The Bay, a regional resource for hospice and ... care at no charge to all healthcare professionals ... in March. CEUs are available. The ongoing trainings ... in Larkspur. For the schedule of trainings, which ...
... BTEL) announced results for its second quarter ended,December 31, ... diluted share,on revenues of $3,186,000. This compares to net ... of $2,859,000 for the second quarter of last,year. For ... net earnings of,$617,000, or $0.22 per diluted share, on ...
Cached Medicine News:Health News:Cleveland Clinic Enters into Agreement with MinuteClinic 2Health News:Cleveland Clinic Enters into Agreement with MinuteClinic 3Health News:Cleveland Clinic Enters into Agreement with MinuteClinic 4Health News:Force Tester Shoulders The Burden 2Health News:QLT announces that it is named as a defendant in an action 2Health News:QLT announces that it is named as a defendant in an action 3Health News:Belly Fat May Make Migraines More Likely 2Health News:Hospice By The Bay Offers Health Care Professionals Free Training in End-of-Life Care 2Health News:Hospice By The Bay Offers Health Care Professionals Free Training in End-of-Life Care 3Health News:Biotel Announces Profitable Second Quarter Ended December 31, 2008 2
(Date:8/27/2015)... Grow , the fastest-growing professional networking organization for women leaders ... World Congress & Business Exposition (CWCBExpo) in ... CWCBExpo in LA will take place September 16-18, 2015 at ... Los Angeles, CA , and is the ... industry. The Women Grow tracks at CWCBExpo ...
(Date:8/27/2015)...   NineSigma the leading innovation partner to ... overall revenue growth and anticipates the creation of over 350 ... Innovation Incentive (OII). In 2013, the ... over $2 million to accelerate adoption of open innovation among ... $1 Billion in revenues. To date over 45 middle market ...
(Date:8/27/2015)... TORONTO , Aug. 27, 2015  Generex ... the issuance of a white paper on the status ... product.  The white paper was presented to the August ... Dr. James H. Anderson, Jr. , MD, the ... viewed online on the Generex website. The ...
Breaking Medicine Technology:Cannabis World Congress in Los Angeles Boasts Women Grow Sponsored Education 2Cannabis World Congress in Los Angeles Boasts Women Grow Sponsored Education 3Cannabis World Congress in Los Angeles Boasts Women Grow Sponsored Education 4State of Ohio and NineSigma Collaborate to Drive Regional Economic Growth and Job Creation 2State of Ohio and NineSigma Collaborate to Drive Regional Economic Growth and Job Creation 3Generex Announces Issuance of Buccal Insulin White Paper 2Generex Announces Issuance of Buccal Insulin White Paper 3Generex Announces Issuance of Buccal Insulin White Paper 4
... Life Sciences, Inc. (NASDAQ: CALP ) ... Nicolaus Healthcare Conference, will be webcast on Wednesday, ... President and CEO of Caliper, will be providing ... webcast can be accessed at http://www.veracast.com/webcasts/stifel/healthcare2011/24107595.cfm . ...
... Rigel Pharmaceuticals, Inc. (Nasdaq: RIGL ) ... executive officer, and Ryan Maynard, executive vice president and ... separate investor conferences in September. Details of the events ... 8th at 10:20 a.m. ETLocation: Boston, MASpeaker: James M ...
Cached Medicine Technology:
... the first polypropylene mesh specifically designed ... directly addresses the critical issues associated ... delivers maximum visibility, enhanced maneuverability and ... through the trocar.,Visilex mesh is the ...
... technique, recommended for the treatment of ... direct inguinal hernias, provides significant advantages ... less overall dissection and is utilized ... The result is increased patient comfort, ...
... longest available wavelength with a unique flat ... efficacy. The unique flat beam profile consistently ... all targeted structures. The Lyra-I uniquely avoids ... Lyra-I patients are protected by patented continuous ...
... nonabsorbable knitted product for use in ... a highly flexible and compliant material ... surgical adaptability, along with maximal porosity ... Mesh is constructed from polyethylene terephthalate, ...
Medicine Products: