Navigation Links
Sanford-Burnham collaborates with 5 Florida-based research organizations
Date:4/2/2013

ORLANDO, Fla., April 2, 2013Sanford-Burnham Medical Research Institute at Lake Nona (Sanford-Burnham) announced the selection of the first five research organizations that will participate in the Florida Translational Research Program (FTRP) to advance drug discovery in the state. The projects focus on cancer, diabetes, and obesity, and are led by scientists from the University of Central Florida, the University of Florida, the University of Miami, Scripps Florida, and Sanford-Burnham. The Program provides Florida-based scientists with access to drug discovery expertise and state-of-the-art infrastructure at Sanford-Burnham.

"We fielded approximately 50 specific inquiries for the program and received a total of 15 valid applications for five project slots," said Layton Smith, Ph.D., director of Drug Discovery Florida at Sanford-Burnham, who oversees the program. "We selected these projects based on scientific merit, technical feasibility, and potential for commercialization. Work on the first collaboration began in February and we expect to complete all projects by the end of the year."

Toward new cancer therapeutics

Three of the projects focus on discovering new treatments for cancer and other tumors. Claes Wahlestedt, M.D., Ph.D., and his team at the University of Miami are trying to find chemical compounds that stop MLL3, a protein that plays a central role in the development of several leukemias, as well as breast and colon cancers. Researchers led by Daiqing Liao, Ph.D., at the University of Florida have shown that a novel drug target for cancer, acetyltransferase p300, is a master regulator of cancer-cell survival. Novel inhibitors of p300 are thus expected to prevent the development of tumors in a variety of cancers. Cristina Fernandez-Valle, Ph.D., at the University of Central Florida and her team seek compounds that block the protein merlin, which has a similar function as p300.

While the research focus of each project varies greatly, all participating scientists agree that having access to state-of-the-art screening technology enhances their ability to do research. "The immediate and potential long-term impact of this funding on my research cannot be overstated," said UCF professor and research scientist Fernandez-Valle. "There is currently no drug treatment for neurofibromatosis, a devastating tumor syndrome diagnosed in children and young adults. The results of this project and the partnership with Sanford-Burnham are critical for us to successfully compete for the continuously diminishing federal funds that we need to eventually develop an effective drug therapy for neurofibromatosis."

On the road to treating diabetes and obesity

The other two projects represent the first steps in the discovery of new medicines to treat diabetes and obesity. Patricia McDonald, Ph.D., at Scripps Florida will collaborate with Sanford-Burnham to identify molecules that block the function of a protein called GPR21, which is known to reduce the effects of insulin on the body. Fraydoon Rastinejad, Ph.D., and his lab at Sanford-Burnham seek to block the action of two other proteins that control metabolism and the expansion of fat cells, Rev-Erbα and Rev-Erbβ.

The Florida Department of Health and Sanford-Burnham established the FTRP as a competitive grant program that provides funding for collaborative drug discovery projects. The overall goal of the program is to translate research discoveries made in Florida laboratories into the medicines of tomorrow.

"As a native Floridian, I am extremely proud to see the first FTRP projects come to life. There is no doubt we have the talent here in Florida to develop the medicines of tomorrow. Through the FTRP collaborations, we have the opportunity to match this talent with our infrastructure and technology platforms at Sanford-Burnham," says Smith.

This first year of the FTRP is a pilot phase with five project slots that were available; the number of projects is expected to increase next year. Applications were invited from investigators who had already developed innovative assays for use both in basic research and in therapeutic development, and who were interested in having their assay screened using Sanford-Burnham's small-molecule library. In the future, the program will accept proposals for more comprehensive projects that may have a chemical component, not yet be ready for high-throughput screening, or require assay development services from Sanford-Burnham.


'/>"/>

Contact: Deborah Robison
drobison@sanfordburnham.org
407-795-2073
Sanford-Burnham Medical Research Institute
Source:Eurekalert

Related medicine news :

1. Sanford-Burnhams Erkki Ruoslahti named to Thomson Reuters Nobel Prize watch list
2. University of Southern Mississippi Professor Collaborates with Houston Police for Eyewitness Research Study
3. ICA Fellow, Dafna Lemish, collaborates with UNICEF on child development initiative
4. PhD Box invites contributions for Research Topics Contest
5. Juice Production in the US Industry Market Research Report from IBISWorld has Been Updated
6. Medical Supplies Wholesaling in the US Industry Market Research Report from IBISWorld has Been Updated
7. Researchers are first to use common virus to fortify adult stem cells
8. Princess Margaret breast cancer research finds new drug target companion prognostic test for hormone therapy resistance
9. Congresswoman Michelle Bachmann Supports Barak Obama's Call to Prioritize Research to "Unlock the Answers to Alzheimer's"
10. Researchers discover new clues about how amyotrophic lateral sclerosis develops
11. Global Biopsy Devices Market - New Market Research Report Published by Transparency Market Research
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... October 13, 2017 , ... “The Journey: From the Mountains to ... to save lost souls in the Philippines. “The Journey: From the Mountains to the ... teacher of the Bible. She has taught all ages and currently teaches a class ...
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... Planet Fitness, ... the U.S., announced today its plans to open a flagship location in Covington, LA ... the former Rooms To Go store next to Office Depot in the Holiday Square ...
(Date:10/12/2017)... ... October 12, 2017 , ... Asante, ... post-acute health care, have expanded their existing home health joint venture through an ... has been operating a joint venture home health company with Asante, delivering clinically ...
(Date:10/12/2017)... , ... October 12, 2017 , ... Leading pediatric oncology ... in Washington, D.C., for the 49th Congress of the International Society of Paediatric ... President of the Center for Cancer and Blood Disorders at Children’s National, ...
(Date:10/12/2017)... , ... October 12, 2017 , ... ... $3,296 in property taxes a year. In some states—like New York, New Jersey, ... By contrast, many overseas retirement havens have extremely low property-tax rates, which contributes ...
Breaking Medicine News(10 mins):
(Date:10/12/2017)... , Oct. 12, 2017 AVACEN Medical , ... company with their  2017 New Product Innovation Award for ... extensive primary and secondary medical device market research by Frost ... its first-to-market OTC, drug-free pain relief product, the AVACEN 100, ... to treating fibromyalgia widespread pain. ...
(Date:10/11/2017)... , Oct. 11, 2017  Caris Life Sciences ... on fulfilling the promise of precision medicine, today announced ... joined Caris, Precision Oncology Alliance™ (POA) as its 17 ... centers, the St. Jude Crosson Cancer Institute will help ... the use of tumor profiling, making cancer treatment more ...
(Date:10/10/2017)... , Oct. 10, 2017   West Pharmaceutical ... innovative solutions for injectable drug administration, today shared the ... ID Adapter for improving the intradermal administration of polio ... Skin Vaccination Summit in May 2017 by Dr. ... Polio Department, World Health Organization (WHO), and recently published ...
Breaking Medicine Technology: