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Sanford-Burnham and Florida Hospital review obesity research progress with Takeda Pharmaceutical
Date:2/15/2012

Orlando, Fla. February 15, 2012 Sanford-Burnham Medical Research Institute (Sanford-Burnham) and Florida Hospital researchers recently returned from Japan where they reviewed the progress that has been made at the mid-point of their research partnership with Takeda Pharmaceutical Company Limited (Takeda). The two-year collaboration focuses on the discovery and evaluation of new therapeutic approaches to obesity. The scientists reported benchmark data that sets the stage for a key element in future drug developmentthe testing of obesity drug candidates.

"The data generated thus far lays the groundwork for analysis of how individuals respond differently to disease," said Steven R. Smith, M.D., an expert in the obesity field and scientific director of the Florida Hospital Sanford-Burnham Translational Research Institute for Metabolism and Diabetes (TRI), where the Florida Hospital portion of the work is being performed. "This partnership with Takeda, TRI and Sanford-Burnham establishes a model to accelerate the development of safe and effective therapies."

During the first year of research, the modeling of fit and obese states laid the groundwork for discovery of a candidate drug for metabolic disease. Clinical research at the TRI assessed the physiological response to dietary changes, such as high sugar or high fat consumption. Across the translational bridge at Sanford-Burnham, patient-derived samples were analyzed using advanced technologies, such as metabolomics, to measure individual response. Ultimately, these metabolic fingerprints may serve as biomarkers and novel drug targets to project how subgroups of patients may respond to new therapies.

This bold collaborative research project involves combining the results of fundamental laboratory studies at Sanford-Burnham with parallel studies conducted with human samples by the research team at Florida Hospital. The results are reviewed on a regular basis in joint meetings of the
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Contact: Deborah Robison
drobison@sanfordburnham.org
407-745-2073
Sanford-Burnham Medical Research Institute
Source:Eurekalert

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