Navigation Links
Sanford-Burnham and Florida Hospital review obesity research progress with Takeda Pharmaceutical

Orlando, Fla. February 15, 2012 Sanford-Burnham Medical Research Institute (Sanford-Burnham) and Florida Hospital researchers recently returned from Japan where they reviewed the progress that has been made at the mid-point of their research partnership with Takeda Pharmaceutical Company Limited (Takeda). The two-year collaboration focuses on the discovery and evaluation of new therapeutic approaches to obesity. The scientists reported benchmark data that sets the stage for a key element in future drug developmentthe testing of obesity drug candidates.

"The data generated thus far lays the groundwork for analysis of how individuals respond differently to disease," said Steven R. Smith, M.D., an expert in the obesity field and scientific director of the Florida Hospital Sanford-Burnham Translational Research Institute for Metabolism and Diabetes (TRI), where the Florida Hospital portion of the work is being performed. "This partnership with Takeda, TRI and Sanford-Burnham establishes a model to accelerate the development of safe and effective therapies."

During the first year of research, the modeling of fit and obese states laid the groundwork for discovery of a candidate drug for metabolic disease. Clinical research at the TRI assessed the physiological response to dietary changes, such as high sugar or high fat consumption. Across the translational bridge at Sanford-Burnham, patient-derived samples were analyzed using advanced technologies, such as metabolomics, to measure individual response. Ultimately, these metabolic fingerprints may serve as biomarkers and novel drug targets to project how subgroups of patients may respond to new therapies.

This bold collaborative research project involves combining the results of fundamental laboratory studies at Sanford-Burnham with parallel studies conducted with human samples by the research team at Florida Hospital. The results are reviewed on a regular basis in joint meetings of the basic laboratory team at Sanford-Burnham, the clinical research team at Florida Hospital, and the Takeda scientists in Shonan, Japan. Videoconferencing, together with semi-annual face-to-face meetings, have allowed for a stimulating exchange of ideas and efficient planning for next steps. The model serves as a high-profile example of how research institutes such as Sanford-Burnham can partner with industry to accelerate discovery of new drugs and diagnostic biomarkers relevant to common diseases such as obesity and diabetes that afflict populations worldwide.

"Our research projects have progressed extremely well and we were anxious to provide a research update to our partners in Japan," said Daniel Kelly, M.D., scientific director of Sanford-Burnham Medical Research Institute at Lake Nona. This was not, however, Takeda's first glimpse at the data. Researchers from Takeda, which is Japan's largest pharmaceutical company, met earlier this year in Orlando. A visiting Takeda scientist also works within the Sanford-Burnham laboratories. "This type of close collaboration during the fundamental discovery phase is part of a new model for academic-commercial partnerships designed to expedite new drug candidates into the development pipeline," said Dr. Kelly.

The partnership, launched in February 2011, aligns complementary strengths in biomedical research, clinical research, and drug development to identify and validate obesity-related biomarkers and new drug targets of mutual interest. The multi-disciplinary team of basic scientists and clinical researchers at Sanford-Burnham and the TRI provides Takeda with a research continuum from laboratory bench to patient bedside.

"We're optimistic that this collaboration will contribute to Takeda's goal of identifying novel targets that will lead to the development of new therapeutics to treat patients suffering from obesity," said Paul Chapman, Ph.D., general manager of Takeda's Pharmaceutical Research Division.

The partners expect that this research agreement will set the stage for future collaborative drug discovery programs aimed at novel therapeutics to treat obesity.

Contact: Deborah Robison
Sanford-Burnham Medical Research Institute

Related medicine news :

1. Moffitt, Sanford-Burnham and Florida Hospital create Personalized Medicine Partnership of Florida
2. Sanford-Burnham researchers find molecular switch that allows melanoma to resist therapy
3. Scripps Health and Sanford-Burnham to collaborate to advance new cancer treatments
4. Dr. Kristiina Vuori Promoted to President of Sanford-Burnham Medical Research Institute
5. Dana-Farber and Sanford-Burnham Institute license flu-targeting antibodies to Genentech and Roche
6. Dengue Fever Cases Subside in Florida, But Threat Remains
7. Florida poll: Research important for state economy, jobs
8. Scripps Florida scientist awarded $2.2 million grant to study hepatitis C
9. US Department of Defense awards University of South Florida $1.59 million for musculoskeletal research
10. ASTRO, Gilda’s Club South Florida join to promote cancer survivorship
11. University of South Florida researchers find blood-brain barrier damaged by disease
Post Your Comments:
(Date:11/25/2015)... ... November 25, 2015 , ... For the first time, Vitalalert ... Organizations, One Beat ” campaign. The partnership between the two groups began in 2014 ... MAP International’s cause. , MAP International was founded in 1954 and is an international ...
(Date:11/25/2015)... ... ... On November 25, 2015, officials of Narconon Arrowhead , the drug rehabilitation ... new cutting edge recovery program that has been 50 years in the making. ... with the purpose to free addicts from the symptoms and negative behaviors of addiction. ...
(Date:11/25/2015)... ... ... Smiles by Stevens is pleased to announce the addition of Botox® for ... aware of the benefits of Botox® in the treatment of moderate facial wrinkling, few ... and pain as a result of Jaw Tension, TMJ (temporo-mandibular joint) disorder, and Bruxism ...
(Date:11/25/2015)... ... November 25, 2015 , ... In an ongoing Clinical Study conducted by an ... IL, UV Angel is evaluating the efficacy of its product and its disinfection protocol. ... 30 beds) from May 2014 through October 2015 at a 360-bed, acute-care, academic medical ...
(Date:11/25/2015)... Spring, Md (PRWEB) , ... November 25, 2015 ... ... Pulmonary Hypertension Association (PHA) announces the nation’s Periwinkle Pioneers, individuals and groups responsible ... history of this disease. The Periwinkle Pioneers, nominated by the public, will receive ...
Breaking Medicine News(10 mins):
(Date:11/25/2015)... 2015 Kitov Pharma ceuticals ... a biopharmaceutical company focused on the development of therapeutic ... today announced the closing of its previously announced underwritten ... ), each representing 20 ordinary shares of the Company, ... ADSs and warrants were issued in a fixed combination ...
(Date:11/25/2015)...  Today AVACEN Medical announced the issue of United States patent No. ... ". This patent shields the company,s AVACEN 100 dry heat therapy medical device and specific methods ... Photo - ... ... ...
(Date:11/25/2015)... , Nov. 25, 2015 USP 800 ... drug preparations (e.g. pharmacists, pharmacy technicians, nurses, physicians, ... technicians). The chapter also covers all entities which ... pharmacies, hospitals, other healthcare institutions, patient treatment clinics, ... --> --> What is ...
Breaking Medicine Technology: