Sanford Barsky, M.D., University of Nevada School of Medicine and Nevada Cancer Institute faculty member publishes scientific paper in the jour... ( RENO/LAS VEGAS Nev. -- Sanford Barsk...)

HOME >> MEDICINE >> NEWS

Sanford Barsky, M.D., University of Nevada School of Medicine and Nevada Cancer Institute faculty member publishes scientific paper in the journal Nature

Date:10/23/2009

RENO/LAS VEGAS, Nev. -- Sanford Barsky, M.D., who holds faculty positions at the University of Nevada School of Medicine as chair of the pathology department and Nevada Cancer Institute chief of pathology, is part of a team that has a paper on transgenic mouse mammary tumors with direct relevance to human breast cancer published in the October 22 issue of the scientific journal Nature.

The article, "Pten in stromal fibroblasts suppresses mammary epithelial tumours," shows that a key signaling pathway that operates in mammary gland connective tissue cells helps to suppress the development of mammary tumors. This study is important because it helps tease apart the complex links between tumor microenvironment and cancer development.

It had been thought that the connective tissue surrounding tumors also known as the tumor microenvironment is important for helping the tumor to grow and survive, but it was not clear just how. This study revealed that deletion of the tumour suppressor gene Pten in fibroblasts connective tissue cells of mammary glands leads to the accelerated development of mammary tumors in mice. Furthermore, tumor development goes hand-in-hand with other changes in the local cellular environment, such as increased blood vessel formation and immune cell infiltration.

Pten loss and related changes in gene expression can also be observed in the connective tissue of breast cancers in women, suggesting that the signalling system operates in humans as well as mice. The team also highlights Pten's influence on a transcription factor called Ets2 as being critical for Pten's tumour suppressive functions in the connective tissue.

Barsky, who serves as chief of pathology for Nevada Cancer Institute in Las Vegas and vice president, academic liaison to University of Nevada, Reno, is also professor and chair of the Department of Pathology of the University of Nevada School of Medicine. He joined both the School of
'/>"/>

Contact: Anne McMillin
amcmillin@medicine.nevada.edu
University of Nevada, Reno
Source:Eurekalert

0

GOOD

Page: 1 2
Related medicine news :

1. The Wallick Companies Establish Sanford Goldston Memorial Fund
2. Dr. Siegals(R) COOKIE DIET(TM) Creator Sanford Siegal, D.O., M.D., Weighs In on Madonnas My husband didnt want to have sex on the cookie diet Remarks
3. Aflac Incorporated to Present at the Sanford C. Bernstein & Co., LLC Twenty-Fourth Annual Strategic Decisions Conference 2008
4. Sanford-Brown College Students Help in Missouri Flood Relief
5. Sanford-Brown Institute - Iselin Raises $11,000 for Ryan's Quest
6. Dr. Sanford Siegal and Weight Loss Success Story Josie Raper, Who Appears on Current People Magazine Cover, to Attend Grand Opening of Dr. Siegals COOKIE DIET Store in Beverly Hills
7. Sanford Children's Hospital Opens New Castle of Care
8. Losing the Last Ten Pounds is the Hardest Part of any Diet Confirms Weight-Loss Expert and Author Dr. Sanford Siegal
9. Dr. Siegals Cookie Diet Book by Physician, Author, and Weight-Loss Expert Sanford Siegal, D.O., M.D., Available May 22nd
10. Dr. Siegal's Cookie Diet Book by Sanford Siegal, D.O., M.D., Available May 22nd
11. Medco CEO to Present at the Sanford C. Bernstein & Co. LLC 25th Annual Strategic Decision Conference 2009

Post Your Comments:

(Date:12/15/2009)... 15 Hosted by the Technology-based Learning ... event recognized 2009,s best eLearning designs. This ... across 4 categories. The Venza Group entry, ... world,s largest hotelier, was selected as the winner ... eLearning" category by the panel of distinguished judges. ...

(Date:12/15/2009)... Today, Coastal Healthcare Administrators officially ... for the first time since its inception ... Administrators will be assuming responsibilities and provider ... for Medical Care. ,, Operating on ... close working relationships with all network physicians, ...

(Date:12/15/2009)... treated with hormones, but when the tumours start growing ... a thesis from the Sahlgrenska Academy, at the University ... new treatments for hormone-resistant prostate cancer. , Late in ... has spread, most patients are given hormone therapy. This ... the tumour shrinks. , "The problem is that the ...

(Date:12/15/2009)... A new study published by The University of Western ... paid and unpaid work report higher average measures of ... models. , The ,shared roles, category, where each partner,s ... total unpaid work, is a growing category that now ... are more likely to be in a shared roles ...

(Date:12/15/2009)... (December 15, 2009) Although seen as a ... levels by inhibiting activity of a transfer protein may ... the Jean Mayer USDA Human Nutrition Research Center on ... University School of Medicine found an association between low ... risk of heart disease in the Framingham Heart Study ...

Breaking Medicine News(10 mins):Health News:The Venza Group Received Top Honors at the American Society of Training & Development (ASTD) eLearning Excellence Awards Ceremony Held on December 10, 2009 2 Health News:Coastal Healthcare Administrators Expands Provider Network to Santa Clara County 2 Health News:More blood vessels in hormone-resistant prostate tumors 2 Health News:Low cholesterol transfer protein activity associated with heart disease risk 2

[0] The Venza Group Received Top Honors at the American Society of Training & Development (ASTD) eLearning Excellence Awards Ceremony Held on December 10, 2009 [0] Coastal Healthcare Administrators Expands Provider Network to Santa Clara County [0] More blood vessels in hormone-resistant prostate tumors [0] Couples who do the dishes together stay happier [0] Low cholesterol transfer protein activity associated with heart disease risk

... Binax, Inc., a leading provider of ... causative pathogens of infectious diseases, announced that it has learned ... and potential customers of the BinaxNow(R) Influenza A & B ... B test has not been validated for detection of the ...

... outcomes were greatly improved when doctors implemented a ... Hospital,s obstetrical unit. Yale School of Medicine researchers ... the American Journal of Obstetrics & Gynecology ... sought to determine if improving communication between medical ...

... found increased chances of urinary/lung malignancies among older men ... men who suffer from moderate chronic kidney disease appear ... of cancers, a team of Australian scientists report. , ... risk for lung and/or urinary cancer, but not prostate ...

... Warner Chilcott Limited (Nasdaq: WCRX ) ... Pharma International Pty. Ltd. ("Mayne") have filed a second ... in the District Court for the District of New ... (the ",161 Patent") which covers DORYX, a tetracycline-class oral ...

... Traditionally, cancer biologists have embraced a simple and direct model ... was seen as bearing total responsibility for the spread of ... seed embedded itself, grew, and reproduced. The result was a ... strategies targeting the tumor seed but neglecting the role of ...

... May 1 One of the leading forensic ... mold, Spiderman Mulholland, is joining forces with a ... Drywall issues facing the United States today.Collaborating with ... investigators, remediation and construction specialists and individuals with ...

Other Medicine News:Health News:Obstetrical unit at Yale-New Haven Hospital achieves dramatic improvement in patient safety 2 Health News:Chronic Kidney Disease Raises Risk for Some Cancers 2 Health News:Chronic Kidney Disease Raises Risk for Some Cancers 3 Health News:Warner Chilcott Files New Lawsuit for Infringement of DORYX(R) Patent 2 Health News:Warner Chilcott Files New Lawsuit for Infringement of DORYX(R) Patent 3 Health News:Where tumor cells boldly go: Weill Cornell cancer biologists shed light on the metastatic niche 2 Health News:Toxic Chinese Drywall Experts Join Forces to Find Remedial Solutions for Homeowners 2

Binax, Inc. Issues Clarification Re BinaxNow(R) Flu A & B Test Obstetrical unit at Yale-New Haven Hospital achieves dramatic improvement in patient safety Chronic Kidney Disease Raises Risk for Some Cancers Warner Chilcott Files New Lawsuit for Infringement of DORYX(R) Patent Where tumor cells boldly go: Weill Cornell cancer biologists shed light on the metastatic niche Toxic Chinese Drywall Experts Join Forces to Find Remedial Solutions for Homeowners

(Date:12/15/2009)... 15 Safe Life Corp ., ... technologies that prevent the spread of infection and ... of its comfortable, breathable, A400 Series respirator to ... global shortage of N95 respirators during the H1N1 ... response to a rapid rise in demand and ...

(Date:12/15/2009)... University Hospital in Belgium, among the first hospitals ... arc therapy, has carried out its first treatment ... Varian Medical Systems ( VAR). A 56-year-old male ... seconds, over four times faster than possible using ... taken more than five minutes using conventional intensity-modulated ...

(Date:12/15/2009)... -- Today, Hill-Rom Holdings, Inc. (NYSE: ... significant strategic and financial initiatives at its Investor ... is hosted by Peter H. Soderberg, president and ... the following topics: ,, Status of multi-year ... and financial updates Smart technologies that interface ...

[0] Safe Life Ramps Production Capacity of Comfortable, Breathable N95 Respirator Amid Worldwide Shortage [0] European Radiotherapy Pioneers Deliver First Varian RapidArc(TM) Treatment for Rectal Carcinoma Patient [0] Hill-Rom Investor Conference Features Business Strategy Updates and New Technologies

... America" feature from the U.S. Census Bureau:, TUESDAY, ... Tuesday, March 11th. One of the most devastating,public health ... day 90 years ago,and experts are still studying it, ... cases were reported among soldiers at Fort Riley,Kansas, just ...

... Accelerates Study Conclusions, CLEVELAND, March 11 ... recently completed a complex podiatry,study that was published ... Skeletal,Radiology. Because of its subspecialty teleradiology model, which,aggregates ... specialized,podiatry expertise, F&S was able to complete the ...

Other Medicine Technology:Franklin & Seidelmann Publishes Complex Podiatry MRI Study 2 Franklin & Seidelmann Publishes Complex Podiatry MRI Study 3

U.S. Census Bureau Daily Feature for March 11 Franklin & Seidelmann Publishes Complex Podiatry MRI Study

... of 96 tips, Sterilized Diamond- Tips are ... Diamond Tips are irradiated by gamma-rays for ... a certificate of sterilization, specifying the date ... free of detectable Rnase, Dnase, DNA, RNA, ...

... to optimize the accuracy and precision of ... is widely recognized by customers throughout the ... over the years and now covers a ... including filter tips, certified pure tips, stepper ...

Designed to fit the Brinkmann Tranferpette and Treff Multi-Channel 300 L Pipettors, this tip provides extra space for repeat pipetting....

For the quantitative determination of luteinizing hormone (LH) concentration in human serum....

Medicine Products:

Tipack (Sterilized) D200 Finntip 50 MBP 300E Multi-Channel Luteinizing Hormone (LH) Enzyme Immunoassay Test Kit

Sanford Barsky, M.D., University of Nevada School of Medicine and Nevada Cancer Institute faculty member publishes scientific paper in the jour...( RENO/LAS VEGAS Nev. -- Sanford Barsk...),Health