Navigation Links
Sandia Labs unlocks secrets of plague with stunning new imaging techniques
Date:5/16/2011

olution to see the earliest binding events, due to the diffraction barrier, which limits what can be resolved using visible light.

"With more traditional visualization methods, you can't see the level of detail you need. It's important to look at not only what's present, but also when and where it's present in the cell," Timlin said.

The technique used by Timlin and Aaron builds on superresolution capabilities developed in recent years, but goes another step by adding dual-color capabilities to the relatively new stochastic optical reconstruction microscopy, or STORM. The combination enables the Sandia team to get a more complete picture by simultaneously imaging LPS and TLR4 receptors on the membrane.

"Current light microscopy capabilities are akin to looking out the window of an airplane and seeing the irrigation circles. You know that plants are there, but you can't tell what kinds of plants they are or what shape the leaves are," said Carson, a Sandia immunologist who was an integral part of the project. "But with this technology, it's like zooming in and seeing the leaves and the structure of the plants. That buys you a lot in terms of understanding what's happening within a cell and specifically how the proteins involved interact."

In 2009, the National Institutes of Health awarded Timlin a five-year, $300,000-a-year innovation grant. Next on the team's agenda is developing the capability to image live cells in real time using spectral Stimulated Emission Depletion, or STED. "We're working toward using a version of superresolution that's much more live-cell friendly, and extending that in terms of what colors are available to do multiple colors, while maintaining the live-cell friendliness. I see this as a beginning of a long development in this type of imaging technology," Timlin said.

Potential applications likely will expand as the technology reveals previously unattainable details of cell signaling. Eventually, the Sandia team would li
'/>"/>

Contact: Stephanie Hobby
shobby@sandia.gov
505-844-0948
DOE/Sandia National Laboratories
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. As Science Unlocks Secrets, Cancer Rates Fall
2. Scientist, Dr Staninger, Unlocks the Mystery of Morgellons Disease
3. Genome of marine organism reveals hidden secrets
4. Bilingual neurons may reveal the secrets of brain disease
5. Secrets of plant warfare underpin quest for safer, more secure global food supply
6. Bedbugs Reveal Their Genetic Secrets in Lab Study
7. New tool for cell research may help unravel secrets of disease
8. Scientists decode secrets of a very common virus that can cause cancer
9. Scientists Seek the Secrets of Sour Taste
10. Leading brain scientists meet in Milwaukee to examine how to uncover the brains secrets
11. Scientists Unravel Secrets of Sound Sleep
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/3/2015)... Boston, MA (PRWEB) May 03, 2015 ... received clearance from the FDA to produce and market ... This device can be used in outpatient settings and ... , The alternate posterior approach has been extensively researched ... a 510k approval to use this approach in conjunction ...
(Date:5/2/2015)... May 02, 2015 Vancouver fencing company, QS ... provide valuable advice to prospective clients related to their questions ... to install railings around their decks and patios. While that ... that pop up once the person rolls up their sleeve ... installing a railing in finding a gate that matches it. ...
(Date:5/2/2015)... Peachtree Audio ” was featured on NewsWatch as part ... and coolest technology products available to consumers. Scott Steinberg, ... the review and shared with viewers how this is ... important part of people’s lives – and as such, ... Peachtree Audio does just that with high-end audio equipment ...
(Date:5/2/2015)... May 02, 2015 With the success that ... is proud to welcome Neida Miranda and Alex Shields to ... Consulting has over 41 years of combined experience working with ... in the dental field for 8 years. She was ... Waco, Texas. Customer service, positive attitude and showing the importance ...
(Date:5/1/2015)... Freeport, ME (PRWEB) May 01, 2015 ... store in Freeport, Maine, reports on a new study ... pain, stiffness, joint swelling and improved physical function as ... people with severe osteoarthritis of the knee. , The ... “ Natural Insights for Well Being® ,” which Royal ...
Breaking Medicine News(10 mins):Health News:Professional Staff at QS Fencing Company Now Provides Advice on Railings and Gates 2Health News:Affordable High-End Audio Equipment was Featured on NewsWatch Television 2Health News:Veatch Dental Consulting Services Welcomes New Team Members 2Health News:New Study Finds Nutrients Ease Arthritis Pain, Retailer Reports 2
... this week by the U.S. Supreme Court will protect the rights of ... LLP . “The Supreme Court’s ruling this week is an important victory ... attorney Robert Kientz. , ... Austin, TX (Vocus) March 6, 2009 -- ...
... but some people don,t realize how precious it really is. 24k gold ... formulas on the market. , ... New York (PRWEB) March 6, 2009 -- While watching ... Gold. It,s common to hear that it has kept a rather high ...
... Diagnosing and treating obstructive sleep apnea may soon ... new research showing that a simplified program using ... positive airway pressure (CPAP) machines to titrate CPAP ... which relies on specialist physicians and sleep studies. ...
... Medical Association (NMA) congratulates the President and his staff ... in today,s forum. The NMA is committed to ... advocacy community, and other stakeholders, to ensure that the ... the President can sign before the Congress adjourns for ...
... of Hispanic health advocates is committed to achieving meaningful ... have work to do to cover the uninsured, improve ... someone has access it is to the type of ... L. Delgado, President and CEO of the National Alliance ...
... Stockholders to Vote the GOLD CardCINCINNATI, March 5 ... announces that RiskMetrics Group,s ISS Governance Services has ... Company,s current Board of Directors and reject all ... and election of replacement Directors, in the Joffe ...
Cached Medicine News:Health News:Supreme Court Ruling is a Victory for Consumers Injured by Dangerous Drugs, Says Hissey Kientz, LLP 2Health News:Supreme Court Ruling is a Victory for Consumers Injured by Dangerous Drugs, Says Hissey Kientz, LLP 3Health News:Gold Not Only Valuable, It's a Healthy Skin Care Ingredient 2Health News:Less costly, more accessible and as effective: Simplified treatment for sleep apnea 2Health News:Less costly, more accessible and as effective: Simplified treatment for sleep apnea 3Health News:Alliance President and CEO Dr. Jane L. Delgado Joins President Obama at White House to Launch Health Reform Agenda 2Health News:Leading Proxy Advisory Firm RiskMetrics Recommends Shareholders Support LCA-Vision Board of Directors and Reject All Proposals by Dissident Joffe Group 2Health News:Leading Proxy Advisory Firm RiskMetrics Recommends Shareholders Support LCA-Vision Board of Directors and Reject All Proposals by Dissident Joffe Group 3
(Date:4/30/2015)... 2015 /PRNewswire/ - Pivotal Therapeutics Inc. (OTCQX: PVTTF) ... focus on Omega-3 therapies for cardiovascular disease (CVD) ... financial results for the fiscal year ended December ... in Canadian dollars unless otherwise stated. ... the right strategic partners and additional capitalization in ...
(Date:4/30/2015)... VIEW, Calif. , April 30, 2015  IRIDEX ... will release its first quarter 2015 financial results after ...   In conjunction with the release, the Company will ... 5:00 p.m. Eastern Time on Thursday, ... the quarter and other business developments. Interested ...
(Date:4/30/2015)... NASHVILLE, Tenn. , April 30, 2015  Cumberland ... it will release first quarter 2015 financial results after ... conference call and live Internet webcast will be held ... Time to discuss the results. To participate ... or 253-237-1032 (for international callers).  A rebroadcast of the ...
Breaking Medicine Technology:Pivotal Therapeutics Announces 2014 Financial Results 2Pivotal Therapeutics Announces 2014 Financial Results 3Pivotal Therapeutics Announces 2014 Financial Results 4Pivotal Therapeutics Announces 2014 Financial Results 5Pivotal Therapeutics Announces 2014 Financial Results 6IRIDEX Announces First Quarter 2015 Conference Call and Release Date 2Cumberland Pharmaceuticals To Announce First Quarter 2015 Financial Results 2
... Pharmasset, Inc. (Nasdaq: VRUS ) has received ... (FDA) for PSI-938 for the treatment of chronic hepatitis C ... polymerase inhibitor of HCV. In March 2011, ... has potent antiviral activity and is generally safe and well ...
... 24, 2011 MedVantx, Inc., the company that created first ... today announced that Inc. Magazine has rated the company as ...  For the third year in a row, MedVantx has made ... Health Industry and thirteenth overall. The Inc. 500/5000 ...
Cached Medicine Technology:PSI-938 Receives Fast Track Designation from the FDA for the Treatment of Chronic Hepatitis C Infection 2PSI-938 Receives Fast Track Designation from the FDA for the Treatment of Chronic Hepatitis C Infection 3MedVantx Honored by Inc. 500/5000 Three Years in a Row 2
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
Medicine Products: