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Same process discovered to both form skeleton and protect it for life
Date:3/12/2008

signaling appears to make bones stronger, but too much of it could result in osteosarcoma, the most common primary malignant bone tumor in children and teenagers. These studies suggest that well timed manipulations of a single process may represent new ways to fight two major bone diseases.

Brendan Lee, M.D., Ph.D., associate professor of Molecular and Human Genetics at the Baylor College of Medicine led the first study along with Boyce. The second study was led by Matthew Hilton, Ph.D., now assistant professor of Orthopaedics and Rehabilitation at the Medical Center, with Fanxin Long, Ph.D., principle investigator of this study. Long is assistant professor of Medicine at Washington University, where, until recently, Hilton was a post-doctoral fellow. They also partnered with the Endocrine Unit at Massachusetts General Hospital. Both studies, supported by grants from the National Institutes of Health, were published online on Feb. 24 and in hard copy on March 6.

Study Details

Having been around since early in evolution, Notch proteins are named for notches in the wings of the flies in which Notch-related genes were discovered. Such protein receptors span a cells outer membrane, enabling external biochemical messages to penetrate cells.

Part of the receptor is exposed to the cells outside and designed to react with a specific signaling molecule (ligand). When a ligand docks into the receptor, like a ship coming into port, it changes the shape of the dock such that it sets off chain reactions inside the cell. When a ligand binds to Notch in particular, part of the protein, the notch intracellular domain (NICD), breaks away inside of the cell, travels to the cells nucleus and influences gene expression there. Gene expression is the process whereby genetic instructions encoded in genes are converted into protein workhorses that make up the bodys structures and carry its signals. In the current case, the NICD signal was sho
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Contact: Greg Williams
Greg_Williams@urmc.rochester.edu
585-273-1757
University of Rochester Medical Center
Source:Eurekalert

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