Navigation Links
Same drug, different results: MUHC researcher on the path to personalized medicine
Date:6/19/2008

This release is available in French.

Montreal, June 18, 2008 Medicine has moved a little bit closer to the era of tailor-made treatments, based on the unique genetic profiles of individual patients, according to recent research conducted by Dr Rima Rozen of the Research Institute of the McGill University Health Centre (RI MUHC) at the Montreal Children's Hospital and McGill University. Her study, published June 18 in the journal Pharmacogenetics and Genomics, shows how minor genetic differences between individuals alter the way a common drug affects the body.

Rozen has measured the impact of Methotrexate -- a drug that inhibits the metabolism of folate -- on mice with an altered MTHFR gene, which is a gene crucial for folate metabolism. The results were striking: after treatment with Methotrexate, mice with the altered gene had approximately 20 per cent less hemoglobin and red blood cells than their counterparts with non-altered genes. The altered mice also showed increased susceptibility to liver and kidney damage following treatment.

"We know that these results are applicable to humans because a parallel mutation in the human MTHFR gene affects human folate metabolism similarly. The results demonstrate that medication affects subjects differently according to individual genetic traits," Dr. Rozen explained. "And tests exist to detect this mutation." Genetic testing would allow physicians the modify treatment based on each patient's personal genetic makeup, limiting potential side effects.

In earlier studies, Rozen's laboratory cloned the MTHFR gene and identified the common variant which interferes in folate metabolism in human populations. Between 10 and 15 per cent of the total caucasian population have two copies of the variant in MTHFR. Folate, a form of water-soluble Vitamin B2, is essential to the production of red bl
'/>"/>

Contact: Isabelle Kling
isabelle.kling@muhc.mcgill.ca
514-843-1560
McGill University Health Centre
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Drug, Pacemaker Fight Irregular Heartbeat
2. No Link Between Anti-Nausea Drug, Heart Trouble
3. AHF Challenges Merck Over Steep Price of Its New AIDS Drug, Isentress
4. Intensive care quality of sleep improved by new drug, reports study
5. A Better Tomorrow Becomes One of the First Rehabilitation Clinics in the Nation to Offer Financing for Its Drug, Alcohol and Gambling Treatment Programs
6. Brain cells work differently than previously thought
7. Different method of evaluating the urinary tract system reduces radiation dose
8. Different HIV rates among gay men and straight people not fully explained by sexual behavior
9. Abaxis Launches The VetScan(R) HM5 a State-of-the-Art 5-Part Differential Veterinary Hematology Analyzer
10. Sense of taste different in women with anorexia nervosa
11. Babies raised in bilingual homes learn new words differently than infants learning one language
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/1/2015)... June 01, 2015 "This milestone opens ... were not previously able to buy and sell shares ... unsolicited orders and also make recommendations to clients as ... an ability to trade shares of our Company,” said ... and information requirements of OTCQB provides our investors greater ...
(Date:6/1/2015)... Note: Dr. Julian is available for interviews ... , A phase III trial funded by the National ... carcinoma in situ (DCIS) now have an additional tool ... (NSABP B-35/NRG Oncology) looked at more than 3,000 DCIS ... with tamoxifen to those who completed five years of ...
(Date:6/1/2015)... NY (PRWEB) June 01, 2015 For ... patients requesting celebrity features. Much like one would request ... stars’ noses, eyes, cheeks, chin and more to illustrate ... filtering apps like FaceTune are ushering in a new ... Manhattan facial plastic surgeon, Sam Rizk, MD, FACS notes ...
(Date:6/1/2015)... There’s never a good time to be sick and need ... , As of June 1, OSF HealthCare is offering ... the Internet. Patients throughout Illinois can access care whenever they ... busy. We know that getting in to see a provider ... it easier,” said Jeffry Tillery, MD, Chief Transformation Officer for ...
(Date:6/1/2015)... June 1, 2015 – Atlanta, GA – EB ... of hospital medicine, emergency medicine, and pediatric emergency medicine, ... its partnership with AgileMD to provide the content from ... mobile application format available on iPhones, iPads and ... excited about the June 1 launch of our hospital ...
Breaking Medicine News(10 mins):Health News:Content Checked Holdings Inc. Upgrades to the OTCQB Marketplace, now available for trading as CNCK 2Health News:Content Checked Holdings Inc. Upgrades to the OTCQB Marketplace, now available for trading as CNCK 3Health News:Content Checked Holdings Inc. Upgrades to the OTCQB Marketplace, now available for trading as CNCK 4Health News:Today at ASCO: Anastrazole Offers Higher Breast Cancer-Free Survival Rates than Tamoxifen Following DCIS, Phase III Study Shows 2Health News:Today at ASCO: Anastrazole Offers Higher Breast Cancer-Free Survival Rates than Tamoxifen Following DCIS, Phase III Study Shows 3Health News:Instagram Filters Launch New Facial Plastic Surgery Trend 2Health News:OSF HealthCare Now Offering OSF OnCall 2Health News:OSF HealthCare Now Offering OSF OnCall 3Health News:EB Medicine Expands Partnership With AgileMD To Launch Hospital Medicine Mobile Application 2Health News:EB Medicine Expands Partnership With AgileMD To Launch Hospital Medicine Mobile Application 3
... ... among winners of the 13th annual Medical Design Excellence Award given by ... pill swallowing difficulties thanks to a specially designed spout. The product has ... that they are able to ingest prescribed medications without stress or discomfort. ...
... ... Valley of the Sun, builder Carl Mulac knew he needed fresh concept, one that ... adult community that was in harmony on many different levels. In harmony with the ... the environment,” said Mulac, CEO of Joseph Carl Homes. , ...
... ... Save Children,s Lives, Fill Key Health Care Gaps Around the World , ... Westport, Conn. (Vocus) -- To address the global shortfall of 4.3 ... women who are front-line health care workers, Save the Children says in its new State ...
... than one-third of U.S. parents surveyed had delayed or refused ... -- Almost one-third of U.S. parents surveyed delayed vaccines for ... refused to have their children immunized, possibly making them more ... that children who don,t receive recommended vaccine doses by the ...
... trend, study finds , TUESDAY, May 4 (HealthDay News) -- ... the United States having an abortion increased nearly 60 percent, ... , According to the report released May 4 by the ... , The proportion of women in the overall U.S. ...
... LA (May 4, 2010) Rates of colorectal cancer ... method, according to data being presented at Digestive Disease ... older populations as well as utilization rates of virtual ... screening guidelines. DDW is the largest international gathering ...
Cached Medicine News:Health News:Oralflo Pill Swallowing Cup Wins Medical Design Excellence Award, Helps Autism Spectrum Kids and Dysphagia Sufferers Take Medications With No Problem 2Health News:Oralflo Pill Swallowing Cup Wins Medical Design Excellence Award, Helps Autism Spectrum Kids and Dysphagia Sufferers Take Medications With No Problem 3Health News:Oralflo Pill Swallowing Cup Wins Medical Design Excellence Award, Helps Autism Spectrum Kids and Dysphagia Sufferers Take Medications With No Problem 4Health News:New 55+ Active Adult Community in the Valley Sings a New Song 2Health News:New 55+ Active Adult Community in the Valley Sings a New Song 3Health News:For a Mother's Day Gift with Lasting Appeal, Invest in Women Health Workers, Says Save the Children 2Health News:For a Mother's Day Gift with Lasting Appeal, Invest in Women Health Workers, Says Save the Children 3Health News:For a Mother's Day Gift with Lasting Appeal, Invest in Women Health Workers, Says Save the Children 4Health News:Misinformation About Vaccine Safety Puts Kids at Risk of Illness 2Health News:Abortion Rates Rising Among the Poor 2Health News:Investigators examine colorectal cancer screening methods among diverse populations 2Health News:Investigators examine colorectal cancer screening methods among diverse populations 3Health News:Investigators examine colorectal cancer screening methods among diverse populations 4Health News:Investigators examine colorectal cancer screening methods among diverse populations 5Health News:Investigators examine colorectal cancer screening methods among diverse populations 6Health News:Investigators examine colorectal cancer screening methods among diverse populations 7Health News:Investigators examine colorectal cancer screening methods among diverse populations 8Health News:Investigators examine colorectal cancer screening methods among diverse populations 9Health News:Investigators examine colorectal cancer screening methods among diverse populations 10
(Date:6/1/2015)... Researchers from University Hospitals Case Medical Center Seidman Cancer ... will present data from several new studies, including a ... patients with advanced solid tumors and a first-of-its-kind analysis ... at the 51 st American Society for Clinical ... . Jennifer Eads , MD, ...
(Date:6/1/2015)... -  Ergoresearch Ltd (TSXV: ERG) – based in ... orthèses et biomécanique» banner  – announces its results for ... amounts in the present release are in Canadian currency. ... 2015 ended this past March 31, 2015 totaled $ 3,299,994 decreasing by ... quarter ended March 31, 2014. This decrease can be explained ...
(Date:6/1/2015)... Women who took vitamin D and calcium supplements had the ... take the supplements, according to a study published today in ... European Menopause and Andropause Society. The study, ... Women,s Health Initiative , one of the largest clinical ... death, disability and impaired quality of life in menopausal women. ...
Breaking Medicine Technology:UH Case Medical Center Experts to Present Data at 51st ASCO Annual Meeting 2UH Case Medical Center Experts to Present Data at 51st ASCO Annual Meeting 3Third Quarter results - Fiscal 2015 - Ergoresearch reports its results for the quarter ended March 31, 2015 2Third Quarter results - Fiscal 2015 - Ergoresearch reports its results for the quarter ended March 31, 2015 3Third Quarter results - Fiscal 2015 - Ergoresearch reports its results for the quarter ended March 31, 2015 4Vitamin D and Calcium Supplements Do Not Improve Menopausal Symptoms 2Vitamin D and Calcium Supplements Do Not Improve Menopausal Symptoms 3Vitamin D and Calcium Supplements Do Not Improve Menopausal Symptoms 4
... connectivity enabled by Unlimited Systems Interlink integration platform, Navigating ... cancer clinics easily meet many of the HITECH Act ... and money by reducing duplicate data entry, streamlining patient ... and reduced denials. Clinics can provide patients ...
... N.J., Oct. 18, 2011 Johnson & Johnson (NYSE: ... the third quarter of 2011, an increase of 6.8% as ... 2.6% and the positive impact of currency was 4.2%.  Domestic ... of 8.3% and a positive currency impact of 8.1%. ...
Cached Medicine Technology:Navigating Cancer and Unlimited Systems Partner to Provide Cancer Clinics With IT Interoperability to Attain HITECH Act Incentives 2Johnson & Johnson Reports 2011 Third-Quarter Results 2Johnson & Johnson Reports 2011 Third-Quarter Results 3Johnson & Johnson Reports 2011 Third-Quarter Results 4Johnson & Johnson Reports 2011 Third-Quarter Results 5Johnson & Johnson Reports 2011 Third-Quarter Results 6Johnson & Johnson Reports 2011 Third-Quarter Results 7Johnson & Johnson Reports 2011 Third-Quarter Results 8Johnson & Johnson Reports 2011 Third-Quarter Results 9Johnson & Johnson Reports 2011 Third-Quarter Results 10Johnson & Johnson Reports 2011 Third-Quarter Results 11Johnson & Johnson Reports 2011 Third-Quarter Results 12Johnson & Johnson Reports 2011 Third-Quarter Results 13Johnson & Johnson Reports 2011 Third-Quarter Results 14
Speculum with malleable plate to support flap during ablation of thestromal bed....
This adjustable lid speculum is angled 45 degrees and has 17 mm wire blades. It was designed to aspirate excess fluid around the eye during cataract and refractive procedures....
Adjustable wire speculum with 17 mm open blades. Lid tension adjustable throughout procedure with thumb screw control. Available with shaft straight or angled 45 degrees....
Open 13 mm blades. Screw-controlled locking mechanism. Dull finish....
Medicine Products: