Navigation Links
Same drug, different results: MUHC researcher on the path to personalized medicine
Date:6/19/2008

This release is available in French.

Montreal, June 18, 2008 Medicine has moved a little bit closer to the era of tailor-made treatments, based on the unique genetic profiles of individual patients, according to recent research conducted by Dr Rima Rozen of the Research Institute of the McGill University Health Centre (RI MUHC) at the Montreal Children's Hospital and McGill University. Her study, published June 18 in the journal Pharmacogenetics and Genomics, shows how minor genetic differences between individuals alter the way a common drug affects the body.

Rozen has measured the impact of Methotrexate -- a drug that inhibits the metabolism of folate -- on mice with an altered MTHFR gene, which is a gene crucial for folate metabolism. The results were striking: after treatment with Methotrexate, mice with the altered gene had approximately 20 per cent less hemoglobin and red blood cells than their counterparts with non-altered genes. The altered mice also showed increased susceptibility to liver and kidney damage following treatment.

"We know that these results are applicable to humans because a parallel mutation in the human MTHFR gene affects human folate metabolism similarly. The results demonstrate that medication affects subjects differently according to individual genetic traits," Dr. Rozen explained. "And tests exist to detect this mutation." Genetic testing would allow physicians the modify treatment based on each patient's personal genetic makeup, limiting potential side effects.

In earlier studies, Rozen's laboratory cloned the MTHFR gene and identified the common variant which interferes in folate metabolism in human populations. Between 10 and 15 per cent of the total caucasian population have two copies of the variant in MTHFR. Folate, a form of water-soluble Vitamin B2, is essential to the production of red bl
'/>"/>

Contact: Isabelle Kling
isabelle.kling@muhc.mcgill.ca
514-843-1560
McGill University Health Centre
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Drug, Pacemaker Fight Irregular Heartbeat
2. No Link Between Anti-Nausea Drug, Heart Trouble
3. AHF Challenges Merck Over Steep Price of Its New AIDS Drug, Isentress
4. Intensive care quality of sleep improved by new drug, reports study
5. A Better Tomorrow Becomes One of the First Rehabilitation Clinics in the Nation to Offer Financing for Its Drug, Alcohol and Gambling Treatment Programs
6. Brain cells work differently than previously thought
7. Different method of evaluating the urinary tract system reduces radiation dose
8. Different HIV rates among gay men and straight people not fully explained by sexual behavior
9. Abaxis Launches The VetScan(R) HM5 a State-of-the-Art 5-Part Differential Veterinary Hematology Analyzer
10. Sense of taste different in women with anorexia nervosa
11. Babies raised in bilingual homes learn new words differently than infants learning one language
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/5/2015)... Ore. (PRWEB) March 05, 2015 ... sciences university founded in 1904, has launched a ... and positive lifestyle changes. The Northwest Center for ... health professionals, support community outreach, and conduct research ... functional medicine, diet and nutrition. The center will ...
(Date:3/5/2015)... Supply & Demand Chain Executive Magazine has officially ... in the supply chain industry, and we are excited ... were included on this year’s list! Russ King and ... to their hard work, their commitment to excellence, and ... client needs and challenges. , Russ and ...
(Date:3/5/2015)... New York, NY (PRWEB) March 05, 2015 ... NY orthopedic Surgeon ( http://www.orthopedicsurgeonnyc.com ) has been named ... in the New York Metro area. Dr. Glashow has ... in its authoritative guide to the top specialty care ... 2015. , The prestigious Castle Connolly program, which carefully ...
(Date:3/5/2015)... (PRWEB) March 05, 2015 As ... Assistants’ (AAPA) review of Clearstream, LLC ’s ... that Clearstream’s MediDefense line of products—led by their ... AAPA’s Affinity Partner Program. , The AAPA—which represents ... across all medical and surgical specialties in the ...
(Date:3/5/2015)... San Diego, CA (PRWEB) March 05, 2015 ... that it is now running on 100% pollution-free ... provider, Arcadia Power. , As an Arcadia ... Environmental Protection Agency’s (EPA) Green Power Partnership requirements, ... and Starbucks that also purchase clean energy. Earth ...
Breaking Medicine News(10 mins):Health News:University of Western States Launches Northwest Center for Lifestyle and Functional Medicine 2Health News:MEBC Leaders Awarded Supply Demand Chain Executive Pros to Know Title For 2015 2Health News:Dr. Jonathan Glashow, NYC Orthopedic Surgeon, Named Top Doctor: New York Metro Area 2Health News:Clearstream’s Line of MediDefense Antimicrobial Products Scores Affinity Partnership With American Academy of Physician Assistants (AAPA) 2Health News:Clearstream’s Line of MediDefense Antimicrobial Products Scores Affinity Partnership With American Academy of Physician Assistants (AAPA) 3Health News:Clearstream’s Line of MediDefense Antimicrobial Products Scores Affinity Partnership With American Academy of Physician Assistants (AAPA) 4Health News:Earth Source Organics to Run on Clean Energy from Arcadia Power 2
... Joseph F. Finn, Jr., C.P.A. ("Finn"), announced ... from pharma companies in the intellectual property of ... in both hematological and solid tumors, as well ... an in vitro setting. Because GCS-100 exhibits ...
... CSX Corporation Chairman and Chief Executive Officer Michael J. ... of his ongoing support of Wounded Warrior Project (WWP).Ward, ... helped create the nation,s first Training and Rehabilitation Advocacy ... complete their transition to civilian lives. Ward,s personal donation ...
... Data from two presentations highlighting the use ... to severe chronic obstructive pulmonary disease (COPD) patients ... the American Thoracic Society in San Diego. ... when added to maintenance tiotropium, resulted in improved ...
... Chandra Wilson Joins Downy and Quilts for Kids, Inc. ... Network Hospitals throughout the United States CINCINNATI, May 19, ... each year in the United States, forced to confront ... home in an unfamiliar environment. In order to ...
... resources, including excerpts from an interview with Dr. ... Mayo Clinic News Blog .SAN FRANCISCO, May 19 ... shows, CSI and CSI: Miami, to actual U.S. homicide ... violent deaths versus actual murders. This study complements previous ...
... line of universal CRT replacements for MRI, CT, ... other medical devices is now available from Medical ... can now extend equipment ROI and lower replacement ... medical grade displays to adapt and display the ...
Cached Medicine News:Health News:Prospect Therapeutics, Inc.'s GCS-100 Exhibits a Low Toxicity Profile in Cancer Patients 2Health News:Michael Ward Cited for Support of Wounded Warrior Project 2Health News:Perforomist Inhalation Solution data to be presented today at American Thoracic Society conference 2Health News:Perforomist Inhalation Solution data to be presented today at American Thoracic Society conference 3Health News:Perforomist Inhalation Solution data to be presented today at American Thoracic Society conference 4Health News:P&G's Downy Fabric Softener Creates the Downy 'Touch of Comfort' Program to Help Provide Quilts to Hospitalized Children 2Health News:P&G's Downy Fabric Softener Creates the Downy 'Touch of Comfort' Program to Help Provide Quilts to Hospitalized Children 3Health News:P&G's Downy Fabric Softener Creates the Downy 'Touch of Comfort' Program to Help Provide Quilts to Hospitalized Children 4Health News:P&G's Downy Fabric Softener Creates the Downy 'Touch of Comfort' Program to Help Provide Quilts to Hospitalized Children 5Health News:CSI: Mayo Clinic Researchers Find Television Shows Inaccurately Portray Violent Crime 2Health News:Universal CRT Replacement Gives New Life to Medical Equipment with Analog Video 2Health News:Universal CRT Replacement Gives New Life to Medical Equipment with Analog Video 3
(Date:3/5/2015)... 2015 Research and Markets ( http://www.researchandmarkets.com/research/5sqnn3/global_rising ... Rising Stars Outlook 2015" report to their offering. ... being sought after with fresh vigor as new targets ... is poised to bring a paradigm change in the ... the Stem cell therapy/Regenerative Medicine space. The ...
(Date:3/5/2015)... DUBLIN , Mar. 05, 2015 Research ... announced the addition of Jain PharmaBiotech,s new report ... Companies" to their offering. ... multi-disciplinary clinical specialty, aimed at improving patient care ... individually adjust the dose of drugs for improving ...
(Date:3/5/2015)... Minn., March 5, 2015  MGC Diagnostics Corporation ... technology company, today reported financial results for the ... , 2015 first quarter domestic equipment, supplies and ... to $3.7 million in the 2014 first quarter.  ... accounts, or $338,000 in revenue, compared to 14 ...
Breaking Medicine Technology:Global Pharma Rising Stars Outlook 2015 2Global Therapeutic Drug Monitoring Report 2015 - Technologies, Markets, and Companies Analysis 2014-2024 2MGC Diagnostics Corporation Reports Fiscal 2015 First Quarter Results 2MGC Diagnostics Corporation Reports Fiscal 2015 First Quarter Results 3MGC Diagnostics Corporation Reports Fiscal 2015 First Quarter Results 4MGC Diagnostics Corporation Reports Fiscal 2015 First Quarter Results 5MGC Diagnostics Corporation Reports Fiscal 2015 First Quarter Results 6MGC Diagnostics Corporation Reports Fiscal 2015 First Quarter Results 7MGC Diagnostics Corporation Reports Fiscal 2015 First Quarter Results 8MGC Diagnostics Corporation Reports Fiscal 2015 First Quarter Results 9MGC Diagnostics Corporation Reports Fiscal 2015 First Quarter Results 10MGC Diagnostics Corporation Reports Fiscal 2015 First Quarter Results 11MGC Diagnostics Corporation Reports Fiscal 2015 First Quarter Results 12
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
Medicine Products: