Navigation Links
Same cell death pathway involved in three forms of blindness, Penn team finds
Date:1/16/2014

Gene therapies developed by University of Pennsylvania School of Veterinary Medicine researchers have worked to correct different forms of blindness. While effective, the downside to these approaches to vision rescue is that each disease requires its own form of gene therapy to correct the particular genetic mutation involved, a time consuming and complex process.

Hoping to develop a treatment that works more broadly across diseases, a Penn Vet team used canine disease models to closely examine how retinal gene activity varied during the progression of three different forms of inherited vision disease. Their results turned up an unexpected commonality: Early on in each of the diseases, genes involved in the same specific pathway of cell death appeared to be activated. These findings point to possible interventions that could curb vision loss across a variety of inherited retinal diseases.

The work, published in PLOS ONE, was conducted by Sem Genini, a senior research investigator; William A. Beltran, assistant professor of ophthalmology; and Gustavo D. Aguirre, professor of medical genetics and ophthalmology, all of Penn Vet's Department of Clinical Studies, Philadelphia.

The team examined three forms of retinal degenerative diseases, rod cone dysplasia 1 being the most severe, or earliest onset, followed by X-linked progressive retinal atrophy 2 and then early retinal degeneration. All of these diseases involve the death of photoreceptor cells and each is caused by a distinct genetic mutation. But what scientists did not know is how the mutations trigger a molecular signaling pathway that leads to the death of photoreceptor cells.

"What we have in mind is to be able to address multiple forms of disease with one treatment," Beltran said. "We wanted to get a better understanding of whether there are any common cell death or cell survival pathways that could be targeted in some of these diseases."

The resear
'/>"/>

Contact: Katherine Unger Baillie
kbaillie@upenn.edu
215-898-9194
University of Pennsylvania
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Tripling tobacco taxes worldwide would avoid 200 million tobacco deaths
2. Jesus Was Not Born On December 25th - Controversial New Novel Tells Compelling Story About His Birth, Life and Death
3. Lung cancer death rates continue to fall, helping the decrease in overall cancer death rates
4. St. Paul Treatment Center Announces New Effort to Curb Opiate-Related Deaths in Region
5. Fosamax Lawsuits Update: Rottenstein Law Group LLP Comments on Reported $28 Million Merck ‘Jaw Death’ Settlement
6. Cigarette smoking after cancer diagnosis increases risk of death
7. New York Truck Accident Lawyer Adnan Munawar Comments on “Freak Accident” Death of 71-Year-Old NYPD Traffic Agent
8. CARING Criteria shows 1 year death risk at time of hospital admission
9. More alcohol and traffic laws mean fewer traffic deaths, NYU Steinhardt study concludes
10. Death of an adult son increases depressive symptoms in mothers, but not fathers
11. Cardiovascular Institute: Unfolded protein response contributes to sudden death in heart failure
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Same cell death pathway involved in three forms of blindness, Penn team finds
(Date:7/3/2015)... , ... July 03, 2015 ... ... the sessions and speaker lineup for its 2015 Annual Conference , ... August 6-8, 2015 at the Renaissance Orlando at SeaWorld in Orlando, Florida. ...
(Date:7/3/2015)... Buffalo, NY (PRWEB) , ... July 03, 2015 ... ... Noonday Learning Lecture took place on June 25, 2015 at 1:00pm. The Association ... presentation explored issues pertaining to injured bicyclists and practical points of investigating these ...
(Date:7/3/2015)... ... ... " Selfie on a Stick ” was featured on NewsWatch as part ... to consumers. Amanda Forstrom, a technology expert and special reporter for NewsWatch, conducted the ... , Almost every smartphone has an incredibly powerful camera built into it. And when ...
(Date:7/2/2015)... ... ... pleased to announce the opening of its newest location in Dallas, Texas. The opening is ... chain was listed as #22 on the Inc. 500 list of fastest growing companies in ... located at:, 3701 W. Northwest Highway, STE 430, Dallas, TX 75220 , “We are excited ...
(Date:7/2/2015)... ... July 02, 2015 , ... Many Fourth of July celebrations ... why Amica Insurance is sharing some tips to promote the proper use ... people go to the emergency room daily with fireworks-related injuries in the month surrounding ...
Breaking Medicine News(10 mins):Health News:RNS Announces Sessions and Speaker Lineup for the 2015 Annual Conference of the Rheumatology Nurses Society 2Health News:RNS Announces Sessions and Speaker Lineup for the 2015 Annual Conference of the Rheumatology Nurses Society 3Health News:Attorney from William Mattar Leads Discussion on Bicycle Accidents 2Health News:Learn How to Take Selfies like Kendall Jenner 2Health News:sweetFrog Opens 18th Location in the Lone Star State 2Health News:6 Fireworks Safety Tips from Amica Insurance 2
... with distractions, study finds , MONDAY, April 26 (HealthDay ... or landing could lead to a critical error. Apparently ... administer medication to hospital patients. , A new ... patients, medication needs increases the chances of error. As ...
... team of researchers has pinpointed the location of bone generating ... and in other bones. The team also has identified ... was conducted at the National Institutes of Health and other ... some of the genetic triggers that control their growth is ...
... Minneapolis Heart Institute Foundation, Minneapolis Heart Institute at Abbott ... convening The Women and Heart Disease Summit in Minneapolis. ... honorary chair person; and co-chair people are Elizabeth Zane ... They will be joined by a faculty ...
... Society of Pediatric Otolaryngology (ASPO) will hold its annual ... Combined Otolaryngology Spring Meetings (COSM) - a joint meeting ... During the ASPO meeting, hundreds of pieces of ... panelists will be presented focusing on children,s ear, nose, ...
... Agency (EPA) Administrator Lisa P. Jackson and NASA ... science and engineering education at the Howard University ... The administrators chose the Howard University Middle ... and sciences among the next generation of leaders. ...
... --Race matters on a neurological level when it comes ... new Northwestern University study. In a rare neuroscience ... showed greater empathy for African-Americans facing adversity in ... Caucasians demonstrated for Caucasian-Americans in pain. "We ...
Cached Medicine News:Health News:Interrupting a Nurse Makes Medication Errors More Likely 2Health News:Interrupting a Nurse Makes Medication Errors More Likely 3Health News:Interrupting a Nurse Makes Medication Errors More Likely 4Health News:NIH study confirms location of stem cells near cartilage-rich regions in bones 2Health News:NIH study confirms location of stem cells near cartilage-rich regions in bones 3Health News:Scientific meeting will host new research in children's ear, nose and throat health 2Health News:EPA and NASA administrators to extend environmental and Earth science agreement 2Health News:Race and empathy matter on neural level 2
(Date:7/4/2015)... July 4, 2015 Adding ... patients with unresectable metastatic colorectal cancer in the ... organ Patients with unresectable metastatic colorectal ... liver experienced the greatest improvement in Progression-Free Survival ... SIR-Spheres Y-90 resin microspheres to a current first-line ...
(Date:7/3/2015)... , July 3, 2015 ... "Cardiac Monitoring & Cardiac Rhythm Management Market ECG, ... Monitoring, Defibrillator, Implantable Cardioverter Defibrillator, Dual Chamber Pacemaker, ... by MarketsandMarkets, the global Cardiac Monitoring (CM) and ... to reach $26,646.5 Million by 2020 from $21,137.7 ...
(Date:7/3/2015)... July 3, 2015 ... vorbehaltlich bestimmter Abschlussbedingungen eine 100-prozentige Beteiligung am ... haben. Mit dieser Übernahme dringt Lupin in ... Umsatz von 765 Mrd. RUB im Jahr ... Welt gehörte (IMS Health). Seit über einem ...
Breaking Medicine Technology:New SIRFLOX Study Data Presented at World Congress of Gastrointestinal Cancer 2New SIRFLOX Study Data Presented at World Congress of Gastrointestinal Cancer 3New SIRFLOX Study Data Presented at World Congress of Gastrointestinal Cancer 4Cardiac Monitoring (CM) and Cardiac Rhythm Management (CRM) Devices Market Worth $26,646.5 Million by 2020 2Cardiac Monitoring (CM) and Cardiac Rhythm Management (CRM) Devices Market Worth $26,646.5 Million by 2020 3Cardiac Monitoring (CM) and Cardiac Rhythm Management (CRM) Devices Market Worth $26,646.5 Million by 2020 4Lupin übernimmt Biocom aus Russland 2Lupin übernimmt Biocom aus Russland 3
... Chronic ... Hepatitis B-,-Studies will also Assess Clevudine,s Sustained Virologic Response Rate for ... HBV-, ... Phase 3 registration clinical trials,of clevudine for the treatment of chronic hepatitis B virus (HBV),infection. ...
... LOS ANGELES, Oct. 1 Signalife, Inc. (Amex:,SGN - ... and,technological evaluation of various new modules for its holter ... an important part of the,Company,s business plans and are ... FDA approval will now be made imminently in the,fourth ...
Cached Medicine Technology:Pharmasset Commences Dosing in Phase 3 Registration Studies of Clevudine for HBV 2Pharmasset Commences Dosing in Phase 3 Registration Studies of Clevudine for HBV 3Pharmasset Commences Dosing in Phase 3 Registration Studies of Clevudine for HBV 4Pharmasset Commences Dosing in Phase 3 Registration Studies of Clevudine for HBV 5Signalife Completes Testing of Modules for Holter and Intra-Cardiac Monitor 2
D-Stat Radial is a dry version of the D-Stat together with a compression band, and is designed for the control of surface bleeding from vascular access sites, including the sites on the radial artery...
The D-Stat Radial hemostat band utilizes a compression band together with the active haemostatic material of the D-Stat to control surface bleeding....
The Prostar XL 8 is a suture mediated closure system. It can be used with 8F sheath. It has two 3-0 braided polyester sutures and also has the safety of guidewire....
... vascular closure device quickly seals ... procedures, allowing for early ambulation ... creates a mechanical seal by ... bio-absorbable anchor and collagen sponge, ...
Medicine Products: