Navigation Links
Same cell death pathway involved in three forms of blindness, Penn team finds
Date:1/16/2014

Gene therapies developed by University of Pennsylvania School of Veterinary Medicine researchers have worked to correct different forms of blindness. While effective, the downside to these approaches to vision rescue is that each disease requires its own form of gene therapy to correct the particular genetic mutation involved, a time consuming and complex process.

Hoping to develop a treatment that works more broadly across diseases, a Penn Vet team used canine disease models to closely examine how retinal gene activity varied during the progression of three different forms of inherited vision disease. Their results turned up an unexpected commonality: Early on in each of the diseases, genes involved in the same specific pathway of cell death appeared to be activated. These findings point to possible interventions that could curb vision loss across a variety of inherited retinal diseases.

The work, published in PLOS ONE, was conducted by Sem Genini, a senior research investigator; William A. Beltran, assistant professor of ophthalmology; and Gustavo D. Aguirre, professor of medical genetics and ophthalmology, all of Penn Vet's Department of Clinical Studies, Philadelphia.

The team examined three forms of retinal degenerative diseases, rod cone dysplasia 1 being the most severe, or earliest onset, followed by X-linked progressive retinal atrophy 2 and then early retinal degeneration. All of these diseases involve the death of photoreceptor cells and each is caused by a distinct genetic mutation. But what scientists did not know is how the mutations trigger a molecular signaling pathway that leads to the death of photoreceptor cells.

"What we have in mind is to be able to address multiple forms of disease with one treatment," Beltran said. "We wanted to get a better understanding of whether there are any common cell death or cell survival pathways that could be targeted in some of these diseases."

The resear
'/>"/>

Contact: Katherine Unger Baillie
kbaillie@upenn.edu
215-898-9194
University of Pennsylvania
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Tripling tobacco taxes worldwide would avoid 200 million tobacco deaths
2. Jesus Was Not Born On December 25th - Controversial New Novel Tells Compelling Story About His Birth, Life and Death
3. Lung cancer death rates continue to fall, helping the decrease in overall cancer death rates
4. St. Paul Treatment Center Announces New Effort to Curb Opiate-Related Deaths in Region
5. Fosamax Lawsuits Update: Rottenstein Law Group LLP Comments on Reported $28 Million Merck ‘Jaw Death’ Settlement
6. Cigarette smoking after cancer diagnosis increases risk of death
7. New York Truck Accident Lawyer Adnan Munawar Comments on “Freak Accident” Death of 71-Year-Old NYPD Traffic Agent
8. CARING Criteria shows 1 year death risk at time of hospital admission
9. More alcohol and traffic laws mean fewer traffic deaths, NYU Steinhardt study concludes
10. Death of an adult son increases depressive symptoms in mothers, but not fathers
11. Cardiovascular Institute: Unfolded protein response contributes to sudden death in heart failure
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Same cell death pathway involved in three forms of blindness, Penn team finds
(Date:12/26/2014)... FL (PRWEB) December 26, 2014 India ... health insurance in the USA, announced today a new ... assist members in choosing the right plan for their ... the complexity out of the selection process when choosing ... by age group with only a few clicks. Many ...
(Date:12/26/2014)... 2014 Parker & Sons, Inc. ... in heating, cooling and plumbing contractor services throughout ... services in 2014 with regard to air-conditioning systems. ... is known for its incredibly hot summers. Working ... intricacies and details of a wide variety of ...
(Date:12/25/2014)... (PRWEB) December 26, 2014 ... BambooFlooringChina.com combines beauty, strength and durability. Today, the ... promotion, which is valid until Jan. 30, 2015. ... grain of traditional hardwood. BambooFlooringChina.com is a well-known ... help consumers worldwide to find a reliable bamboo ...
(Date:12/25/2014)... December 25, 2014 Product liability lawsuits ... hip recall ( http://www.consumerinjurylawyers.com/DePuy/ ) continue to move forward ... an Order issued in the U.S. District Court, Northern ... convene an open conference on January 7, 2015, at ... Courthouse in West Palm Beach, Florida. The Conference is ...
(Date:12/25/2014)... Recently, Dylan Queen, a famous online company supplying women’s ... discounted prom dresses, most of which are priced under ... company, the promotion is valid until Jan. 22, 2015; ... UK market. , The prom dresses in this new ... A-line strapless, empire strapless chiffon, one shoulder, floor-length, V-neck ...
Breaking Medicine News(10 mins):Health News:India Network Health Insurance Announces new Comprehensive Pre-existing Condition Coverage policy for Visitors to the United States 2Health News:India Network Health Insurance Announces new Comprehensive Pre-existing Condition Coverage policy for Visitors to the United States 3Health News:Parker & Sons Announces Record Demand For 24 Hour Emergency Services In 2014 With Regard To Air-Conditioning Systems 2Health News:Parker & Sons Announces Record Demand For 24 Hour Emergency Services In 2014 With Regard To Air-Conditioning Systems 3Health News:BambooFlooringChina.com: click strand woven bamboo flooring promotion valid until Jan. 30, 2015. 2Health News:Federal Court Overseeing DePuy ASR Hip Lawsuit Set to Convene Conference in January, Bernstein Liebhard LLP Reports 2Health News:Federal Court Overseeing DePuy ASR Hip Lawsuit Set to Convene Conference in January, Bernstein Liebhard LLP Reports 3Health News:Dylan Queen: Cheap Prom Dresses for the UK Market 2
... Partners Joins Forces with 130-Year-Old Organization, ... advance its,human-animal bond initiative, the American Humane ... to offer direct services in animal-assisted,activities and ... becomes a program of American Humane, which ...
... Johnson seeks insights into chronic, illnesses, including heart failure and ... ... VENTURA, Calif., Oct. 8 VivoMetrics announced today,that noted researcher Bruce ... the VivoMetrics LifeShirt(R) System to,the South Pole to collect valuable data for ...
... NEW YORK, Oct. 8 The Physicians Coalition,for ... fat dissolving,fat melting, injection lipolysis or other injectable ... medical treatments. These should not,be mistaken as an ... "Injections to unwanted fat, using compounded pharmaceuticals, ...
... Oct. 8 Health Management Systems,Inc. (HMS) today ... Peer Review,Systems, Inc. d/b/a/ Permedion, an independent health ... Ohio. With this,acquisition, HMS augments its portfolio of ... state Medicaid agencies and,managed care organizations. Permedion ...
... Population of Singapore to Use Eclipsys Solutions to Help Coordinate ... ... Facilities -, BOCA RATON, Fla., Oct. 8 Eclipsys,Corporation(R), (Nasdaq: ... healthcare provider in Singapore, has selected,Eclipsys Sunrise Clinical Manager(TM) as its ...
... Maryland for a fourth straight year, ranking 18th of the fastest-growing ... ... 8 CBaySystems and Services, Inc.,has been named for a fourth straight ... the 50 fastest,growing technology, media, telecommunications, and life sciences companies,in Maryland, by ...
Cached Medicine News:Health News:American Humane Association Adds Direct Services in Animal-Assisted Activities and Therapy 2Health News:American Humane Association Adds Direct Services in Animal-Assisted Activities and Therapy 3Health News:VivoMetrics' LifeShirt Going to South Pole to Uncover Clues to High-Altitude Illness 2Health News:VivoMetrics' LifeShirt Going to South Pole to Uncover Clues to High-Altitude Illness 3Health News:Consumer Safety Alert on Fat Dissolving Injections 2Health News:Consumer Safety Alert on Fat Dissolving Injections 3Health News:HMS Acquires Permedion to Expand Clinical Review Capabilities 2Health News:SingHealth Selects Eclipsys Solutions to Help Improve Clinical Outcomes, First Sunrise Clinical Manager Client Outside of North America 2Health News:SingHealth Selects Eclipsys Solutions to Help Improve Clinical Outcomes, First Sunrise Clinical Manager Client Outside of North America 3Health News:CBaySystems Selected to Receive Deloitte's 2007 Maryland Technology Fast 50 Award 2Health News:CBaySystems Selected to Receive Deloitte's 2007 Maryland Technology Fast 50 Award 3
(Date:12/24/2014)... Dec. 23, 2014   Assurex Health, a ... to healthcare providers for behavioral health and chronic ... $30 million in equity financing from new and ... , President and Chief Executive Officer. ... development of Assurex Health,s GeneSight ® ...
(Date:12/24/2014)... In response to urgent requests from the Deputy Minister ... Leone , Direct Relief delivered two 10-bed medical tents ... of local health workers who contract Ebola while fighting the ... center was constructed for foreign health care workers who may ... local Sierra Leonean health workers. With ...
(Date:12/22/2014)... Mass. , Dec. 22, 2014 ... leading manufacturer of innovative dialysis products, announced today ... has cleared its System One™ to perform hemodialysis ... known as home nocturnal hemodialysis. NxStage,s® System One ... by the FDA for this indication. ...
Breaking Medicine Technology:Assurex Health Secures $30 Million Financing Round to Continue Growth in Neuropsychiatric Pharmacogenomics 2Assurex Health Secures $30 Million Financing Round to Continue Growth in Neuropsychiatric Pharmacogenomics 3Assurex Health Secures $30 Million Financing Round to Continue Growth in Neuropsychiatric Pharmacogenomics 4First Ebola Treatment Unit for Local Health Workers Arrives in Sierra Leone 2NxStage Receives FDA Clearance for Home Nocturnal Hemodialysis 2NxStage Receives FDA Clearance for Home Nocturnal Hemodialysis 3
... Capital Partners, a leading private equity firm, today announced ... Executive Officer of Nycomed, as Healthcare Operating Executive.  Mr. ... Nycomed during Avista,s ownership of the company, which was ... 9.6 billion. Under Mr. Bjorklund,s leadership, Nycomed ...
... Biotechnology, Inc., a development stage biopharmaceutical company, today ... worldwide commercial rights to neratinib, a potent, irreversible ... the epidermal growth factor receptors, ErbB1 (EGFR), ErbB2 ... studied in the neoadjuvant, adjuvant and metastatic settings ...
Cached Medicine Technology:Avista Capital Partners Appoints Hakan Bjorklund as Healthcare Operating Executive 2Avista Capital Partners Appoints Hakan Bjorklund as Healthcare Operating Executive 3Puma Biotechnology Announces Licensing Agreement with Pfizer for the Development and Commercialization of Neratinib, an Investigational Pan-HER Inhibitor; Closes $55 Million Private Placement and Completes Merger 2Puma Biotechnology Announces Licensing Agreement with Pfizer for the Development and Commercialization of Neratinib, an Investigational Pan-HER Inhibitor; Closes $55 Million Private Placement and Completes Merger 3Puma Biotechnology Announces Licensing Agreement with Pfizer for the Development and Commercialization of Neratinib, an Investigational Pan-HER Inhibitor; Closes $55 Million Private Placement and Completes Merger 4Puma Biotechnology Announces Licensing Agreement with Pfizer for the Development and Commercialization of Neratinib, an Investigational Pan-HER Inhibitor; Closes $55 Million Private Placement and Completes Merger 5
... ultrasonic aspirator, portable unit ... aspirator for the fragmentation ... available only outside the ... a very compact design ...
Extremely wide blade opening. Excellent bio and MRI compatibility. Lot number on each clip. Long reliable history. Deflected large type, opening width 7.0 mm and length 5 mm....
Extremely wide blade opening. Excellent bio and MRI compatibility. Lot number on each clip. Long reliable history. Deflected large type, opening width 7.0 mm and length 5 mm....
Extremely wide blade opening. Excellent bio and MRI compatibility. Lot number on each clip. Long reliable history. Deflected large type, opening width 8.0 mm and length 5 mm....
Medicine Products: