Navigation Links
Salmonella's sweet tooth predicts its downfall
Date:5/19/2009

For the first time UK scientists have shown what the food poisoning bug Salmonella feeds on to survive as it causes infection: glucose.

Their discovery of Salmonella's weakness for sugar could provide a new way to vaccinate against it. The discovery could also lead to vaccine strains to protect against other disease-causing bacteria, including superbugs.

"This is the first time that anyone has identified the nutrients that sustain Salmonella while it is infecting a host's body," says Dr Arthur Thompson from the Institute of Food Research.

The nutrition of bacteria during infection is an emerging science. This is one of the first major breakthroughs, achieved in collaboration with Dr. Gary Rowley at the University of East Anglia.

Salmonella food poisoning causes infection in around 20 million people worldwide each year and is responsible for about 200,000 human deaths. It also infects farm animals and attaches to salad vegetables.

During infection, Salmonella bacteria are engulfed by immune cells designed to kill them. But instead the bacteria multiply.

Salmonella must acquire nutrients to replicate. The scientists focused on glycolysis, the process by which sugars are broken down to create chemical energy. They constructed Salmonella mutants unable to transport glucose into the immune cells they occupy and unable to use glucose as food. These mutant strains lost their ability to replicate within immune cells, rendering them harmless

"Our experiments showed that glucose is the major sugar used by Salmonella during infection," said Dr Thompson.

The mutant strains still stimulate the immune system, and the scientists have filed patents on them which could be used to develop vaccines to protect people and animals against poisoning by fully virulent Salmonella.

Glycolysis occurs in most organisms including other bact
'/>"/>

Contact: Andrew Chapple
andrew.chapple@bbsrc.ac.uk
44-160-325-1490
Norwich BioScience Institutes
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. World War II Air Force Veteran Remembers Kisses Sweeter Than Wine
2. Ingredient in Probiotic Sweetener Boosts Immune System
3. Fructose-Sweetened Drinks Up Metabolic Syndrome Risk
4. A Childs Sweet Tooth May Be All in the Bones
5. Hot Flash! - Sweet Pea Productions Releases Blitzed by Menopause: A Guys Guide to Menopause
6. NatureSweet(R) Celebrates Snacking With an Online Natural Talent Show
7. Berry Chill Offers Sweet Valentines Day Deal for Couples
8. Novel prostate cancer vaccine taking aim at cancer cell sweet spot
9. Surf Sweets Launches Natural, Organic Candy Line at More Than 250 Toys"R"Us Stores Across the Country
10. Ocean Spray(R) Announces Sugar-Free Drink Mixes - A Sweet Way for Dieters to Stick to Their Resolutions
11. Sweet Surprise: Even Former Critics Dispel Long-Held Myths About High Fructose Corn Syrup
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Salmonella's sweet tooth predicts its downfall
(Date:10/22/2014)... The United States is now mandating that all ... Africa land at one of five airports equipped ... In a statement released Tuesday, Homeland Security ... air passengers from Guinea, Liberia and Sierra Leone ... -- New York City,s Kennedy International Airport, Washington ...
(Date:10/22/2014)... 2014 During the Western United States’ ... runs dangerously low, Southern Oregon’s water is proving resistant ... the lowest mountain snow pack on record in 2014, ... early autumn.* That was the observation of journalist-hikers Art ... “Hiking Southern Oregon,” during an interview with water advocate ...
(Date:10/22/2014)... Lintelus, Inc., an event software provider, ... Sales, will be speaking on the subject of “Event ... October 28, at the Holiday Inn in New York ... well as a Tech Demo at 12:45pm, to educate ... more engaging event experience. , The Annual Meetings Technology ...
(Date:10/22/2014)... Two sisters in high school have developed ways to ... Krishen use electronic stethoscopes, which electronically amplify body sounds, ... or heartbeats. Ilina, a senior at Port Huron ... way to detect early lung damage in people exposed ... recorded one breath cycle each from 16 smokers, 25 ...
(Date:10/22/2014)... Dennis Thompson HealthDay Reporter ... was diagnosed with Ebola while working for NBC News ... leave the special isolation unit at Nebraska Medical Center in Omaha, ... hospital said Tuesday. A blood test confirmed by the U.S. ... can head home to Providence, R.I., NBC News reported ...
Breaking Medicine News(10 mins):Health News:Passengers From Ebola-Affected Countries Must Land at Designated U.S. Airports 2Health News:Passengers From Ebola-Affected Countries Must Land at Designated U.S. Airports 3Health News:Southern Oregon Is West’s Most Drought Proof Fresh Water Region Say Hiking Guide Authors 2Health News:Southern Oregon Is West’s Most Drought Proof Fresh Water Region Say Hiking Guide Authors 3Health News:Southern Oregon Is West’s Most Drought Proof Fresh Water Region Say Hiking Guide Authors 4Health News:Jay Cormier, Sr. Vice President of Sales for Lintelus, Speaks about Event Technology Integration at Meetings Technology Expo in NYC 2Health News:Teen Sisters Develop Ways to Measure Lung, Heart Damage 2Health News:U.S. Cameraman Treated for Ebola 'Free' of the Virus 2Health News:U.S. Cameraman Treated for Ebola 'Free' of the Virus 3
... (HealthDay News) -- A treatment currently being studied may ... build-up of plaque in artery walls that can lead ... conducting the study, published in the Sept. 12 issue ... with atherosclerosis who were randomly assigned to be treated ...
... Depression to Their Physicians , Many adults subscribe to ... to their primary care physician. In a survey of ... more reasons for not talking to a primary care ... reason being concern the physician would recommend antidepressants (23 ...
... HealthDay Reporter , MONDAY, Sept. 12 (HealthDay News) ... men become fathers, perhaps because they don,t need to compete ... bonding with their children. The findings don,t prove that ... the hormonal systems in men may detect that they,ve become ...
... new, minimally invasive way of treating irregular heartbeats by ... one such heart rhythm disorder, and it,s the most ... 70 percent of patients with the disorder who were ... of any heart rhythm irregularities one year out from ...
... By Dennis Thompson HealthDay Reporter , MONDAY, Sept. ... to check for colon cancer will become the standard screening ... slam-dunk. The method, known as virtual colonoscopy, combines X-ray ... length of the colon, the large intestine. It allows doctors ...
... Steven Reinberg HealthDay Reporter , MONDAY, Sept. 12 ... (NSAIDs) such as Advil, Motrin and Aleve may slightly increase ... Millions of people use these drugs regularly for pain and ... cancers, the researchers added. "NSAIDs have been associated ...
Cached Medicine News:Health News:New Drug Boosts 'Good' Cholesterol in Study Patients 2Health News:September/October 2011 Annals of Family Medicine Tip Sheet 2Health News:September/October 2011 Annals of Family Medicine Tip Sheet 3Health News:September/October 2011 Annals of Family Medicine Tip Sheet 4Health News:September/October 2011 Annals of Family Medicine Tip Sheet 5Health News:September/October 2011 Annals of Family Medicine Tip Sheet 6Health News:September/October 2011 Annals of Family Medicine Tip Sheet 7Health News:September/October 2011 Annals of Family Medicine Tip Sheet 8Health News:Testosterone Levels Seem to Fall With Fatherhood 2Health News:Testosterone Levels Seem to Fall With Fatherhood 3Health News:Freeze and desist: Disabling cardiac cells that can cause arrhythmia 2Health News:Virtual Colonoscopy Still Has Its Skeptics 2Health News:Virtual Colonoscopy Still Has Its Skeptics 3Health News:Virtual Colonoscopy Still Has Its Skeptics 4Health News:NSAID Painkillers Linked to Risk of Kidney Cancer 2Health News:NSAID Painkillers Linked to Risk of Kidney Cancer 3
(Date:10/22/2014)... , October 22, 2014 Investor-Edge ... Inc. (NASDAQ: FOLD ), Progenics Pharmaceuticals Inc. ... THLD ), Idera Pharmaceuticals Inc. (NASDAQ: ... Free research on these five companies can be accessed ... 21, 2014, the NASDAQ Composite ended at 4,419.48, up ...
(Date:10/22/2014)... Oct. 22, 2014   Reproductive Medicine Associates ... in the field of infertility, presents new clinical ... screening. The research abstract, released during the 70 ... (ASRM) meeting in Honolulu, Hawaii ... gene defect (SGD) pre-implantation genetic diagnosis (PGD). ...
(Date:10/22/2014)... -- AVACEN Medical announced today that its AVACEN 100 ... by the U.S. Food and Drug Administration. This clearance ... Internet for: the temporary relief of joint pain ... sprains . Logo - http://photos.prnewswire.com/prnh/20141021/153513 ... a sophisticated medical device incorporating over 3,000 firmware instructions ...
Breaking Medicine Technology:Market Momentum on Biotech Stocks - Amicus Therapeutics, Progenics Pharma, Threshold Pharma, Idera Pharma, and Merrimack Pharma 2Market Momentum on Biotech Stocks - Amicus Therapeutics, Progenics Pharma, Threshold Pharma, Idera Pharma, and Merrimack Pharma 3Market Momentum on Biotech Stocks - Amicus Therapeutics, Progenics Pharma, Threshold Pharma, Idera Pharma, and Merrimack Pharma 4Market Momentum on Biotech Stocks - Amicus Therapeutics, Progenics Pharma, Threshold Pharma, Idera Pharma, and Merrimack Pharma 5New IVF Research Highlights Improved Genetic Screening Approach To Help Parents Have Healthier Babies 2New IVF Research Highlights Improved Genetic Screening Approach To Help Parents Have Healthier Babies 3AVACEN Medical Announces FDA Clearance of First Medical Device with Internal Game Mode 2
... Technology Co., Ltd, one of the leading manufacturers of medical ... machine. Noble Laser,s IPL machine always enjoys a ... world choose this machine because of high configuration, stable quality ... free choosing. Please log in to www.noblelaser.com to ...
...  The Preserve Community Pharmacy Access NOW! (PCPAN) coalition today applauded ... the proposed merger between Express Scripts, Inc. (ESI) and ... In a letter to the Federal Trade Commission (FTC), ... 100,000 active and retired union mine workers. ...
Cached Medicine Technology:Beijing Noble Laser Technology Co., Ltd Offers a Great Deal on its IPL Machine 2Nationwide Coalition Applauds United Mine Workers For Voicing Concern Over Proposed ESI/Medco Merger 2
Angulated, blunt and pointed tips....
Pointed, 12 cm long....
All Bovie LLETZ Loop and Square electrodes feature tungsten wire for superior shape and integrity throughout the excision procedure. They use a standard 3/32" (2.3 mm) shaft....
Disposable 1 1/4" Tungsten Micro Needle, Ins., Straight...
Medicine Products: