Navigation Links
Salmonella's sweet tooth predicts its downfall

For the first time UK scientists have shown what the food poisoning bug Salmonella feeds on to survive as it causes infection: glucose.

Their discovery of Salmonella's weakness for sugar could provide a new way to vaccinate against it. The discovery could also lead to vaccine strains to protect against other disease-causing bacteria, including superbugs.

"This is the first time that anyone has identified the nutrients that sustain Salmonella while it is infecting a host's body," says Dr Arthur Thompson from the Institute of Food Research.

The nutrition of bacteria during infection is an emerging science. This is one of the first major breakthroughs, achieved in collaboration with Dr. Gary Rowley at the University of East Anglia.

Salmonella food poisoning causes infection in around 20 million people worldwide each year and is responsible for about 200,000 human deaths. It also infects farm animals and attaches to salad vegetables.

During infection, Salmonella bacteria are engulfed by immune cells designed to kill them. But instead the bacteria multiply.

Salmonella must acquire nutrients to replicate. The scientists focused on glycolysis, the process by which sugars are broken down to create chemical energy. They constructed Salmonella mutants unable to transport glucose into the immune cells they occupy and unable to use glucose as food. These mutant strains lost their ability to replicate within immune cells, rendering them harmless

"Our experiments showed that glucose is the major sugar used by Salmonella during infection," said Dr Thompson.

The mutant strains still stimulate the immune system, and the scientists have filed patents on them which could be used to develop vaccines to protect people and animals against poisoning by fully virulent Salmonella.

Glycolysis occurs in most organisms including other bacteria that occupy host cells. Disrupting how the bacteria metabolise glucose could therefore be used to create vaccine strains for other pathogenic bacteria, including superbugs.

The harmless strains could also be used as vaccine vectors. For example, the flu gene could be expressed within the harmless Salmonella strain and safely delivered to the immune system.

The next stage of the research will be to test whether the mutants elicit a protective immune response in mice.

In Germany the nutrition of bacteria is the subject of a six-year priority programme of research to investigate why bacteria are able to multiply inside a host's body to cause disease.


Contact: Andrew Chapple
Norwich BioScience Institutes

Related medicine news :

1. World War II Air Force Veteran Remembers Kisses Sweeter Than Wine
2. Ingredient in Probiotic Sweetener Boosts Immune System
3. Fructose-Sweetened Drinks Up Metabolic Syndrome Risk
4. A Childs Sweet Tooth May Be All in the Bones
5. Hot Flash! - Sweet Pea Productions Releases Blitzed by Menopause: A Guys Guide to Menopause
6. NatureSweet(R) Celebrates Snacking With an Online Natural Talent Show
7. Berry Chill Offers Sweet Valentines Day Deal for Couples
8. Novel prostate cancer vaccine taking aim at cancer cell sweet spot
9. Surf Sweets Launches Natural, Organic Candy Line at More Than 250 Toys"R"Us Stores Across the Country
10. Ocean Spray(R) Announces Sugar-Free Drink Mixes - A Sweet Way for Dieters to Stick to Their Resolutions
11. Sweet Surprise: Even Former Critics Dispel Long-Held Myths About High Fructose Corn Syrup
Post Your Comments:
Related Image:
Salmonella's sweet tooth predicts its downfall
(Date:6/25/2016)... ... June 25, 2016 , ... The temporary closing of Bruton Memorial Library on June 21 due ... up a new, often overlooked aspect of head lice: the parasite’s ability to live away ... a common occurrence, but a necessary one in the event that lice have simply gotten ...
(Date:6/25/2016)... ... June 25, 2016 , ... On Friday, June 10, Van Mitchell, ... at Work award to iHire in recognition of their exemplary accomplishments in worksite health ... annual Maryland Workplace Health & Wellness Symposium at the BWI Marriott in Linthicum Heights. ...
(Date:6/24/2016)... ... ... Marcy was in a crisis. Her son James, eight, was out of control. Prone to ... , “When something upset him, he couldn’t control his emotions,” remembers Marcy. “If there ... my other children and say he was going to kill them. If we were ...
(Date:6/24/2016)... , ... June 24, 2016 , ... Topical BioMedics, Inc, makers of Topricin and MyPainAway ... call for a minimum wage raise to $12 an hour by 2020 and then adjusting ... restore the lost value of the minimum wage, assure the wage floor does not erode ...
(Date:6/24/2016)... ... 2016 , ... Strategic Capital Partners, LLC (SCP) in concert ... capital for emerging technology companies. SCP has delivered investment events and professional ... than a million dollars of capital investment for five companies. The ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... DUBLIN , June 23, 2016 ... the "Pharmaceutical Excipients Market by Type (Organic Chemical ... Preservative), Formulation (Oral, Topical, Coating, Parenteral) - Global Forecast ... The global pharmaceutical excipients ... 2021 at a CAGR of 6.1% in the forecast ...
(Date:6/23/2016)... Research and Markets has announced the ... report to their offering. ... favourable commercial environment for MedImmune to enter. The US ageing ... serve to drive considerable growth for effective anti-influenza medications. The ... sales considerably, but development is still in its infancy. ...
(Date:6/23/2016)... June 23, 2016 Revolutionary technology ... Oticon , industry leaders in advanced audiology and ... Oticon Opn ™, the world,s first internet connected ... for IoT devices.      (Photo: ... a number of ,world firsts,: , TwinLink™ ...
Breaking Medicine Technology: