Navigation Links
Salk study links diabetes and Alzheimer's disease
Date:4/30/2008

LA JOLLA, CA Diabetic individuals have a significantly higher risk of developing Alzheimers disease but the molecular connection between the two remains unexplained. Now, researchers at the Salk Institute for Biological Studies identified the probable molecular basis for the diabetes Alzheimers interaction.

In a study published in the current online issue of Neurobiology of Aging, investigators led by David R. Schubert, Ph.D., professor in the Cellular Neurobiology Laboratory, report that the blood vessels in the brain of young diabetic mice are damaged by the interaction of elevated blood glucose levels characteristic of diabetes and low levels of beta amyloid, a peptide that clumps to form the senile plaques that riddle the brains of Alzheimers patients.

Although the damage took place long before the first plaques appeared, the mice suffered from significant memory loss and an increase in inflammation in the brain. Although the toxic beta amyloid peptide was first isolated from the brain blood vessels of Alzheimers patients, the contribution of pathological changes in brain vascular tissue to the disease has not been well studied, says Dave R. Schubert, Ph.D., professor and head of the Cellular Neurobiology Laboratory. Our data clearly describe a biochemical mechanism to explain the epidemiology, and identify targets for drug development.

Alzheimers and diabetes are two diseases that are increasing at an alarming rate within the U.S. population. Alzheimers affects one in 10 Americans over 65 years of age and nearly 50 percent of those over 85 years old. Similarly, 7 percent or approximately 20 million Americans have diabetes, with the vast majority of these individuals being over 60.

Recent epidemiological studies have shown that diabetic patients have a 30 to 65 percent higher risk of developing Alzheimers disease compared to non-diabetic individuals. The increased risk applies to both type 1 and type 2 diabetes, whi
'/>"/>

Contact: Gina Kirchweger
Kirchweger@salk.edu
858-453-410-01340
Salk Institute
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Penn study finds pro-death proteins required to regulate healthy immune function
2. New study shows promise in reducing surgical risks associated with surgical bleeding
3. Study, meta-analysis examine factors associated with death from heatstroke
4. Study suggests loss of 2 types of neurons -- not just 1 -- triggers Parkinsons symptoms
5. Study says COPD testing is not measuring up
6. Preclinical study suggests organ-transplant drug may aid in lupus fight
7. Ability to cope with stress can increase good cholesterol in older white men, study finds
8. High alcohol consumption increases stroke risk, Tulane study says
9. Mailman School of Public Health study examines link between racial discrimination and substance use
10. Pitt study finds inequality in tobacco advertising
11. Stanford study highlights cost-effective method of lowering heart disease risks
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... Glendale, AZ (PRWEB) January 22, 2015 Padre ... a long supporter of Pro Player Health Alliance ... with Padre Murphy's in getting everyone, including NFL greats, treated ... one of the leading groups supporting the cause in the ...
(Date:1/22/2015)... 2015 Blue Cross and Blue Shield of ... what it means to “Live Fearless.” , The ... share their stories about how they or someone they know ... by living in the moment. By telling these types of ...
(Date:1/22/2015)... 2015 A new white paper by ... person-centeredness in the long-term care environment as well as ... continuum. The paper, “The Power of Person-Centeredness in Long-Term ... practices of the patient, resident and family experience in ...
(Date:1/22/2015)... 2015 Carinsurancesavings.biz has released a new blog ... dismemberment insurance . , Purchasing an accidental death and ... advantageous. This type of rider provides benefits if the insured ... considered a lesser form of life insurance. , AD&D ...
(Date:1/22/2015)... Recently, Weddingshe.com has added many trendy Champagne wedding ... annual revenues in the past three years. Today, the business ... , According to the sales manager of the company, this ... in 2015. This point can be reflected on the discounted ...
Breaking Medicine News(10 mins):Health News:Padre Murphy's Holds NFL Retired Players Association Party Star Studded Event With Bud Light and Pro Player Health Alliance Sponsoring 2Health News:Padre Murphy's Holds NFL Retired Players Association Party Star Studded Event With Bud Light and Pro Player Health Alliance Sponsoring 3Health News:Blue Cross and Blue Shield of Minnesota to Showcase “Faces of Fearless” 2Health News:The Power of Person-Centeredness in Long-Term Care Explored by The Beryl Institute 2Health News:The Power of Person-Centeredness in Long-Term Care Explored by The Beryl Institute 3Health News:Accidental Death and Dismemberment Insurance Can Be Purchased at Low Prices Online 2Health News:Weddingshe Announces A Special Offer On Its Popular Glamorous Wedding Dresses 2
... Ideal for ADA-Compliant Wall Fixtures; One-Fourth the Power of ... 25 OptoElectronix today announced a unique LED-based lighting ... SSL (solid state lighting) for commercial lighting fixtures. It ... bulb at just one-fourth the power and has a ...
... ... Interactive Multimedia category for its Orthopedic Patient Education Library. , ... Margate, FL (PRWEB) June 25, 2009 -- ... best of American business. All organizations operating in the U.S.A. were eligible to submit ...
... ... fiber syrup), Yum-Yum Zymes; and Brown Rice Protein in Chocolate, Vanilla and Berry flavors at ... Center/The Venetian Resort Hotel Las Vegas, July 9-11, 2009. , ... Los Angeles, CA (PRWEB) June 25, 2009 -- Jarrow Formulas®, ...
... Foundation for VoIP Communications at Additional Invacare Locations , ... Corp., a leading global manufacturer of wheelchairs and home ... manage its new European communications network. A fully managed ... to employees at the company,s 20 sales and production ...
... 25, 2009 -- Many parents worry about their child,s exposure ... wide variety of personal care products, children,s toys, and medical ... has been associated with negative changes in endocrine function. ... Journal of Pediatrics examines the possibility that in utero ...
... be faced with harsh decisions , , FOLSOM, Pa., ... Pennsylvania families should not have to worry about losing health ... -- and urged the General Assembly to adequately fund the ... , "The nation is experiencing one of the most ...
Cached Medicine News:Health News:OptoElectronix Offers Lighting Manufacturers A Unique Integrated LED Light Engine With 1,000 Lumens Light Output 2Health News:OptoElectronix Offers Lighting Manufacturers A Unique Integrated LED Light Engine With 1,000 Lumens Light Output 3Health News:iHealthSpot, Inc Named Winner in the 2009 STEVIE' AWARDS (American Business Awards) 2Health News:iHealthSpot, Inc Named Winner in the 2009 STEVIE' AWARDS (American Business Awards) 3Health News:iHealthSpot, Inc Named Winner in the 2009 STEVIE' AWARDS (American Business Awards) 4Health News:Jarrow Formulas, Inc. to Unveil Children's Natural Health Products at Upcoming Natural MarketPlace 2009 Show in Las Vegas 2Health News:Jarrow Formulas, Inc. to Unveil Children's Natural Health Products at Upcoming Natural MarketPlace 2009 Show in Las Vegas 3Health News:Verizon Private IP Quadruples Network Capacity for Invacare's European Operations 2Health News:Verizon Private IP Quadruples Network Capacity for Invacare's European Operations 3Health News:Pennsylvania Governor Rendell Urges General Assembly to Support Children's Health Insurance Program 2
(Date:1/23/2015)... Jan. 23, 2015  Now available for sale, The Armor1 ... that prevents ankle sprains by cushioning the ankle from ... securely around the outside of any shoe type and ... while still offering protection against sprains. With customers in ...
(Date:1/23/2015)... , Jan. 23, 2015  CytoSorbents Corporation (NASDAQ CM: ... CytoSorb® extracorporeal cytokine adsorber to reduce deadly inflammation ... receipt of $385,642, net of transaction costs, in ... Technology Business Tax Certificate Transfer Program sponsored by ...
(Date:1/22/2015)... , Jan. 22, 2015  ViewRay™, a privately held ... into an exclusive distributor agreement with ITOCHU Corporation (Tokyo ... therapy system for the treatment of cancer in ... system, is the world,s first and only MRI-guided radiation ...
Breaking Medicine Technology:The Armor1 Ankle Roll Guard is the New Breakthrough Solution for Ankle Sprain Prevention! 2CytoSorbents Receives $385,000 in Non-Dilutive Funding from the New Jersey Technology Business Tax Certificate Transfer Program 2CytoSorbents Receives $385,000 in Non-Dilutive Funding from the New Jersey Technology Business Tax Certificate Transfer Program 3ITOCHU Named the Exclusive Distributor for ViewRay's MRI-Guided Radiation Therapy System in Japan 2
... BRUSSELS, Belgium, Sept. 15 ,Drais Pharmaceuticals, Inc. and ... a global agreement to develop and commercialize UNBS,5162, ... for cancer. UNBS 5162 was discovered by Unibioscreen ... United States in cancer patients with,advanced solid tumors ...
... Researchers at the Barbara,Ann Karmanos Cancer Institute ... a HER2 DNA vaccine that has shown to ... study was reported in the September 15 issue,of ... for Cancer,Research., ( http://www.newscom.com/cgi-bin/prnh/20071106/KARMANOSCANCERINSTITUTELO ,GO), Wei-Zen ...
Cached Medicine Technology:Unibioscreen and Drais Pharmaceuticals Partner to Develop and Commercialize UNBS 5162 for Treatment of Cancer 2Unibioscreen and Drais Pharmaceuticals Partner to Develop and Commercialize UNBS 5162 for Treatment of Cancer 3DNA Vaccine Developed at the Karmanos Cancer Institute Fights HER2-Positive Cancers 2
... concave seats and standard-sized backrests with ... seats, backrests, armrests, and casters and ... for the following environments: industry, education, ... care and office. • With cast ...
... concave seats and standard-sized backrests with ... seats, backrests, armrests, and casters and ... for the following environments: industry, education, ... care and office. • With cast ...
... chairs with concave seats and standard-sized ... options like seats, backrests, armrests, and ... are recommended for the following environments: ... control, health care and office. • ...
... concave seats and standard-sized backrests with ... seats, backrests, armrests, and casters and ... for the following environments: industry, education, ... care and office. • With cast ...
Medicine Products: