Navigation Links
Salk study links diabetes and Alzheimer's disease
Date:4/30/2008

LA JOLLA, CA Diabetic individuals have a significantly higher risk of developing Alzheimers disease but the molecular connection between the two remains unexplained. Now, researchers at the Salk Institute for Biological Studies identified the probable molecular basis for the diabetes Alzheimers interaction.

In a study published in the current online issue of Neurobiology of Aging, investigators led by David R. Schubert, Ph.D., professor in the Cellular Neurobiology Laboratory, report that the blood vessels in the brain of young diabetic mice are damaged by the interaction of elevated blood glucose levels characteristic of diabetes and low levels of beta amyloid, a peptide that clumps to form the senile plaques that riddle the brains of Alzheimers patients.

Although the damage took place long before the first plaques appeared, the mice suffered from significant memory loss and an increase in inflammation in the brain. Although the toxic beta amyloid peptide was first isolated from the brain blood vessels of Alzheimers patients, the contribution of pathological changes in brain vascular tissue to the disease has not been well studied, says Dave R. Schubert, Ph.D., professor and head of the Cellular Neurobiology Laboratory. Our data clearly describe a biochemical mechanism to explain the epidemiology, and identify targets for drug development.

Alzheimers and diabetes are two diseases that are increasing at an alarming rate within the U.S. population. Alzheimers affects one in 10 Americans over 65 years of age and nearly 50 percent of those over 85 years old. Similarly, 7 percent or approximately 20 million Americans have diabetes, with the vast majority of these individuals being over 60.

Recent epidemiological studies have shown that diabetic patients have a 30 to 65 percent higher risk of developing Alzheimers disease compared to non-diabetic individuals. The increased risk applies to both type 1 and type 2 diabetes, which share hyperglycemia as a common pathogenic factor.

Many studies have focused on altered insulin signaling in the brain as a possible mechanism for the association between Alzheimers disease and diabetes but researchers paid much less attention to the direct affects of increased blood glucose levels on brain function and the pathogenesis of Alzheimers, explains lead author Joseph R. Burdo, Ph.D., a former postdoctoral researchers in Schuberts lab and now an assistant professor at Bridgewater State College in Bridgewater, Massachusetts.

To get at the bottom of the question why diabetes predisposes people to Alzheimers disease as they age, the Salk researchers Schubert, Burdo and Qi Chen, in collaboration with diabetes expert Nigel Calcutt, a professor in UCSDs Department of Pathology, induced diabetes in young mice, whose genetic background predisposes them to acquire the symptoms of Alzheimers with old age.

These mice suffered damage to blood vessels well before any overt signs of Alzheimers disease such as nerve cell death or the acquisition of amyloid deposits, the hallmark of the disease, could be detected in their brains. Further experiments revealed that the vascular damage was due to the overproduction of free radicals, resulting in oxidative damage to the cells lining the brains blood vessels.

While all people have a low level of amyloid circulating in their blood, in diabetics there may be a synergistic toxicity between the amyloid and high level of blood glucose that is leading to the problems with proper blood vessel formation, says Burdo.

An earlier study by Schubert and his team has revealed that the exposure of cells to amyloid causes free radical production prompting a clinical trial investigating whether the antioxidant and free radical scavenger vitamin E would be beneficial for the treatment of Alzheimers disease.

While this initial trial was only marginally successful, ongoing work in Schuberts lab centers on a new family of drugs that has shown promise for preventing Alzheimers disease and perhaps the vascular damage associated with diabetes.


'/>"/>

Contact: Gina Kirchweger
Kirchweger@salk.edu
858-453-410-01340
Salk Institute
Source:Eurekalert

Related medicine news :

1. Penn study finds pro-death proteins required to regulate healthy immune function
2. New study shows promise in reducing surgical risks associated with surgical bleeding
3. Study, meta-analysis examine factors associated with death from heatstroke
4. Study suggests loss of 2 types of neurons -- not just 1 -- triggers Parkinsons symptoms
5. Study says COPD testing is not measuring up
6. Preclinical study suggests organ-transplant drug may aid in lupus fight
7. Ability to cope with stress can increase good cholesterol in older white men, study finds
8. High alcohol consumption increases stroke risk, Tulane study says
9. Mailman School of Public Health study examines link between racial discrimination and substance use
10. Pitt study finds inequality in tobacco advertising
11. Stanford study highlights cost-effective method of lowering heart disease risks
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... Viejo, California (PRWEB) , ... June 25, 2016 , ... ... to fit their specific project," said Christina Austin - CEO of Pixel Film Studios. ... fully customizable and all within Final Cut Pro X . Simply select a ...
(Date:6/25/2016)... ... June 25, 2016 , ... ... non-athletes recover from injury. Recently, he has implemented orthobiologic procedures as a method ... —Johnson is one of the first doctors to perform the treatment. Orthobiologics are ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... A recent ... that most people are unfamiliar with. The article goes on to state that individuals ... also many of these less common operations such as calf and cheek reduction. The ...
(Date:6/24/2016)... ... June 24, 2016 , ... Marcy was in a crisis. Her son James, eight, was ... his family verbally and physically. , “When something upset him, he couldn’t control his emotions,” ... He would throw rocks at my other children and say he was going to kill ...
(Date:6/24/2016)... ... June 24, 2016 , ... Dr. ... accelerated orthodontic treatment. Dr. Cheng has extensive experience with all areas of orthodontics, ... and accelerated osteogenic orthodontics. , Micro-osteoperforation is a revolutionary adjunct to orthodontic ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... , June 24, 2016 ... the "Structural Electronics 2015-2025: Applications, Technologies, Forecasts" ... In-Mold Electronics, Smart Skin, Structural ... Structural electronics involves electronic and/or ... protective structures, replacing dumb structures such as vehicle ...
(Date:6/24/2016)... June 24, 2016 Dehaier Medical Systems Ltd. ... which develops, markets and sells medical devices and wearable ... signed a strategic cooperation agreement with Hongyuan Supply Chain ... Chain") on June 20, 2016, to develop Dehaier,s new ... cooperation agreement, Dehaier will leverage Hongyuan Supply Chain,s sales ...
(Date:6/24/2016)... Research and Markets has announced the addition of the ... to their offering. ... World Market for Companion Diagnostics covers the world market for ... report includes the following: , World IVD ... (N. America, EU, ROW), 2015-2020 , World IVD Companion ...
Breaking Medicine Technology: