Navigation Links
Salivary glands as organs of immunity: New research makes oral immunization easier to swallow
Date:2/10/2011

If you don't like shots or needles, you're in luck. New research published online in The FASEB Journal (http://www.fasebj.org) gives the development of new oral vaccinations a shot in the arm thanks to discoveries involving the salivary glands of mice. In addition, this research report also offers a tantalizing glimpse of vaccines that could prevent infection at mucosal surfaces, even if direct injections into the body fail to cause immunity. This technique may be effective for a wide range of diseases from influenza to cholera.

"Our work highlights the ability of the salivary glands to act as an alternative mucosal route for administering vaccines, which would lead to protective immune responses both locally and systemically," said Lucille London, Ph.D., a researcher involved in the work from the School of Dental Medicine and Department of Oral Biology and Pathology at Stony Brook University in Stony Brook, NY. "Thus, in the future, salivary gland inoculation may become a clinically acceptable method in which to vaccinate groups of individuals against new and emerging pathogenic challenges."

To make this advance, the researchers studied two groups of mice. The first group received live cytomegalovirus directly into their salivary glands. These mice demonstrated an immune response in the salivary glands, and the researchers observed an increase in the number and types of cells associated with antibodies that were protective in the saliva. Importantly, these antibodies were also found in other mucosal secretions and in the serum of these mice, suggesting that these proteins spread to other locations in the body. Additionally, the researchers observed structural and functional changes in the immunized salivary glands, causing them to resemble lymph node-like structures commonly seen in injection-based immunizations. The second group of mice was given an inactive virus that did not cause an infection in the salivary glands. These mice demonstrated no active immune response when compared to the first group. When both sets of mice were exposed to the same virus at a later time, only the group immunized with an active virus was protected from future infection. This discovery opens the doors for similar research involving the use of weakened viruses to determine if they will also confer immunity through salivary glands.

"It's no fun for doctors or parents when kids struggle during routine immunization," said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal. "It's even less fun when you are dealing with adults who are deathly afraid of shots in various parts of their body. This work shows that salivary glands may become the first line of defense in active and passive immunization."


'/>"/>

Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
Source:Eurekalert

Related medicine news :

1. Cutting-edge salivary diagnostics research presented at AADR 3rd Fall Focused Symposium
2. Cancers of sweat glands, other skin-related structures may be increasing in United States
3. Nitric oxide-releasing wrap for donor organs and cloth for therapeutic socks
4. New Sensors Stick to Organs to Monitor Health
5. Number of Americans willing to donate organs rises, but still not keeping pace with need
6. Kidney transplants: Expanding the pool of available organs
7. Shortage of Transplant Organs Spurs Proposals But No Solution
8. UT Southwestern unveils next generation CT scanner that views whole organs in a heartbeat
9. Organs From High-Risk Donors Often Shunned, Study Finds
10. Embedded Mobile & M2M Device revenues to Rise to Almost $19 Billion Globally by 2014, Says Juniper Research
11. 2010 HSR Impact Award recognizes surgical safety research
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... 13, 2017 , ... Apple Rehab Shelton Lakes , which specializes in ... the facility as part of a disaster drill on October 3rd. , Apple Rehab ... City Emergency Manager, as well as the Connecticut Long Term Care Mutual Aid ...
(Date:10/13/2017)... , ... October 13, 2017 , ... Global Healthcare Management’s ... Alexandria Park in Milford, NJ. This free event, sponsored by Global Healthcare Management’s ... The fun run is geared towards children of all ages; it is a ...
(Date:10/13/2017)... ... ... “The Journey: From the Mountains to the Mission Field”: the story of ... Philippines. “The Journey: From the Mountains to the Mission Field” is the creation of ... taught all ages and currently teaches a class of ladies at her church, which ...
(Date:10/12/2017)... ... October 12, 2017 , ... Planet Fitness, one of ... announced today its plans to open a flagship location in Covington, LA at 401 ... Rooms To Go store next to Office Depot in the Holiday Square shopping center. ...
(Date:10/12/2017)... ... ... Asante, a nationally recognized health system in southern Oregon, ... health joint venture through an agreement, effective October 1, 2017, to create AccentCare ... company with Asante, delivering clinically integrated care, for the past eight years. This ...
Breaking Medicine News(10 mins):
(Date:10/4/2017)... LAWRENCE, Mass. , Oct. 4, 2017 /PRNewswire/ ... developer of single-use, self-contained, illuminating medical devices, today ... National Health Surveillance Agency (or Agência Nacional ... ®. The first single-use, cordless surgical retractor with ... ONETRAC provides optimal access, illumination and exposure of ...
(Date:10/2/2017)... Oct. 2, 2017 The Rebound mobile app is ... to reverse the tide of prescription drug addiction. The app ... medicine intake and stepping down their dosage in a safe, ... in December 2017; the first 100,000 people to sign up ... http://www.rebound-solution.com/ ...
(Date:9/25/2017)... --  Montrium , an industry leader in powerful ... Trial Master Files & Inspection Readiness Conference ( ... Services has selected eTMF Connect to ... a leading European contract research organization (CRO), will ... enable greater collaboration with sponsors, improve compliance and ...
Breaking Medicine Technology: