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Safeway Inc. and the Prostate Cancer Foundation to Fund Landmark Prostate Cancer Research Collaboration
Date:11/15/2007

>The theory that heat can be used to help kill cancer cells comes from an observation and review of scientific evidence by cancer researchers at Johns Hopkins that testicular cancer patients, like seven-time Tour de France winner Lance Armstrong, have much higher rates of survival than others with different kinds of advanced cancer. Testicular cancer begins in the testes, which are a few degrees cooler than the rest of the body. The structural machinery of cancer cells spreading outside the testes may be altered by the higher body temperatures, making them more susceptible to standard chemotherapy treatments than other cancer types.

While heat therapy is in limited experimental use, researchers believe the key to an effective treatment may be selectively heating cancer cells, which can also prevent damage in adjacent healthy tissues. The goal, note S.T.A.R. team members, is to find out the best way to deliver heat directly to cancer cells. To do so, some of the S.T.A.R. Program researchers will investigate the use of nanoparticles that are attracted to specific proteins carried by cancer cells. Once the nanoparticle locates this specific protein, it can enter the cancer cell, heating it from the inside out after exposure to a magnetic field. The S.T.A.R. Program team will look at this and other mechanisms for targeted heat delivery systems to cancer cells.

In addition to Dr. Getzenberg at Johns Hopkins, the research team for the S.T.A.R. Program includes:

-- Theodore L. DeWeese, M.D., Professor and Department Chairman of

Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins

University School of Medicine (Baltimore)

-- Donald Coffey, Ph.D., Professor of Urology, Oncology, Pathology,

Pharmacology and Molecular Sciences, Johns Hopkins University School

of Medicine (Baltimore)

-- Kenneth Pienta, M.D., Professor of Internal Medicine and Surgery,

and Director of the NCI Research Cen
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SOURCE Safeway Inc.
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