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SWOG names 5 cancer researchers outstanding Young Investigators
Date:9/8/2010

in creating this resistance in some breast cancer cells. Kalinsky's proposed study would target these latter two receptors directly in an attempt to make tumor cells more sensitive to trastuzumab.

Tina (Tianhong) Li, M.D., Ph.D., assistant professor of medicine, UC Davis Cancer Center:

Li proposes a phase II study pitting the drugs crizotinib and pemetrexed against crizotinib alone in patients whose non-small cell lung cancer (NSCLC) hasn't responded to platinum-based therapy and harbors a particular genetic abnormality known as the EML4-ALK fusion oncogene.

Current data suggest that the frequency of several variants of this EML4-ALK fusion oncogene, which is only 4-6% among all NSCLC patients, is particularly high in younger patients and in non-smokers or light smokers. The study would screen this subset of NSCLC patients for the genetic marker to determine trial eligibility.

SWOG's Lung Committee approved this proposal for further development during the spring 2010 Group Meeting.

Margarett Shnorhavorian, M.D., M.P.H., assistant professor of urology, University of Washington:

Shnorhavorian is the first investigator to participate in the course as part of a recent partnership between SWOG and the Children's Oncology Group (COG) that opens the YITC to researchers honored with COG's Aflac Young Investigator Award in Adolescent and Young Adult Oncology, which Shnorhavorian received in 2009.

She has proposed a pilot study of infertility and gonadal dysfunction in male survivors of adolescent and young adult (AYA) osteosarcomas who were treated with cisplatin chemotherapy. Cisplatin and other similar drugs have cumulative dose ranges above which most patients will be rendered infertile, but Shnorhavorian says population-based studies are needed to describe the prevalence of these effects in survivors of AYA malignancies.


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Contact: Frank DeSanto
fdesanto@umich.edu
734-998-0114
University of Michigan Health System
Source:Eurekalert

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