Myeloma cells typically do not grow outside the bone marrow, so developing extramedullary relapsed disease may be a sign of change in MM biology. This proposed study would also explore whether identifying gene expression signatures in these patients can improve our understanding of the molecular mechanisms involved in progression of this disease from the bone marrow into extramedullary sites.
Heather Greenlee, N.D., Ph.D., assistant professor of epidemiology and medical oncology, Columbia University:
With doctoral training in cancer epidemiology and clinical training as a naturopathic physician, Greenlee researches the effects of complementary and alternative medicine therapies on treatment toxicities, patient quality of life, cancer recurrence, and survival.
She has proposed a study among breast and colorectal cancer survivors to assess the feasibility of a weight loss intervention using the Curves weight loss program, which combines circuit-based exercise with a calorie-reduced diet high in fruits and vegetables and low in fat. This study concept is now under review at the National Cancer Institute as proposed SWOG trial S1008.
Kevin Kalinsky, M.D., assistant professor of medicine, Columbia University:
Kalinsky has proposed a phase I study of a regimen that combines antibodies to human epidermal growth factor receptor 3 (HER3) and insulin-like growth factor 1 receptor (IGF-1R) with trastuzumab (Herceptin) in patients with advanced solid tumors.
Trastuzumab can help control breast cancer in which the HER2 gene is amplified (multiple copies of the gene are made) or HER2 itself is overexpressed. It does this by interfering with the HER2 receptor, but many patients become resistant to the drug's effects. Recent research suggests that HER2, HER3, and IGF-1R work together
|Contact: Frank DeSanto|
University of Michigan Health System