Navigation Links
SWOG names 5 cancer researchers outstanding Young Investigators
Date:9/8/2010

ANN ARBOR, Mich. The Southwest Oncology Group, or SWOG, one of the nation's largest cancer clinical trials networks, has selected five talented researchers who are early in their careers for its 2010 Young Investigator Training Course (YITC). These five will attend a three-day workshop September 13 15 in Seattle, WA for intensive training in how to design and conduct cancer clinical trials.

To date this nationally acclaimed program has provided intensive mentorship and career support to 56 investigators. With detailed instruction in protocol development, trial management, and statistical analysis, the course is designed to build a cohort of trained clinical trial researchers with a thorough understanding of Group procedures and the ability to efficiently plan and execute high-priority studies, which in some cases might enroll thousands of patients at hundreds of treatment sites.

Each Young Investigator presents a research proposal as part of the application process, and those proposals are closely reviewed and refined during the workshop. Many of the proposals advanced in previous workshops have since been launched as studies with National Cancer Institute funding.

Costs of the Young Investigator program are paid for with a gift from The Hope Foundation (thehopefoundation.org), a philanthropic arm of the Southwest Oncology Group that raises funds for educational and research efforts.

Below are the names of the 2010 SWOG Young Investigators and descriptions of their proposals.

Sikander Ailawadhi, assistant professor of medicine, University of Southern California:

Ailawadhi has proposed a clinical trial to test the effect of a three-drug combination of carfilzomib, cyclophosphamide, and dexamethasone in multiple myeloma (MM) patients who have disease relapse outside the bone marrow, known as extramedullary relapse. "This is an increasingly identified condition which carries a very poor prognosis," says Ailawadhi, "but there are no specific therapeutic approaches for it yet."

Myeloma cells typically do not grow outside the bone marrow, so developing extramedullary relapsed disease may be a sign of change in MM biology. This proposed study would also explore whether identifying gene expression signatures in these patients can improve our understanding of the molecular mechanisms involved in progression of this disease from the bone marrow into extramedullary sites.

Heather Greenlee, N.D., Ph.D., assistant professor of epidemiology and medical oncology, Columbia University:

With doctoral training in cancer epidemiology and clinical training as a naturopathic physician, Greenlee researches the effects of complementary and alternative medicine therapies on treatment toxicities, patient quality of life, cancer recurrence, and survival.

She has proposed a study among breast and colorectal cancer survivors to assess the feasibility of a weight loss intervention using the Curves weight loss program, which combines circuit-based exercise with a calorie-reduced diet high in fruits and vegetables and low in fat. This study concept is now under review at the National Cancer Institute as proposed SWOG trial S1008.

Kevin Kalinsky, M.D., assistant professor of medicine, Columbia University:

Kalinsky has proposed a phase I study of a regimen that combines antibodies to human epidermal growth factor receptor 3 (HER3) and insulin-like growth factor 1 receptor (IGF-1R) with trastuzumab (Herceptin) in patients with advanced solid tumors.

Trastuzumab can help control breast cancer in which the HER2 gene is amplified (multiple copies of the gene are made) or HER2 itself is overexpressed. It does this by interfering with the HER2 receptor, but many patients become resistant to the drug's effects. Recent research suggests that HER2, HER3, and IGF-1R work together in creating this resistance in some breast cancer cells. Kalinsky's proposed study would target these latter two receptors directly in an attempt to make tumor cells more sensitive to trastuzumab.

Tina (Tianhong) Li, M.D., Ph.D., assistant professor of medicine, UC Davis Cancer Center:

Li proposes a phase II study pitting the drugs crizotinib and pemetrexed against crizotinib alone in patients whose non-small cell lung cancer (NSCLC) hasn't responded to platinum-based therapy and harbors a particular genetic abnormality known as the EML4-ALK fusion oncogene.

Current data suggest that the frequency of several variants of this EML4-ALK fusion oncogene, which is only 4-6% among all NSCLC patients, is particularly high in younger patients and in non-smokers or light smokers. The study would screen this subset of NSCLC patients for the genetic marker to determine trial eligibility.

SWOG's Lung Committee approved this proposal for further development during the spring 2010 Group Meeting.

Margarett Shnorhavorian, M.D., M.P.H., assistant professor of urology, University of Washington:

Shnorhavorian is the first investigator to participate in the course as part of a recent partnership between SWOG and the Children's Oncology Group (COG) that opens the YITC to researchers honored with COG's Aflac Young Investigator Award in Adolescent and Young Adult Oncology, which Shnorhavorian received in 2009.

She has proposed a pilot study of infertility and gonadal dysfunction in male survivors of adolescent and young adult (AYA) osteosarcomas who were treated with cisplatin chemotherapy. Cisplatin and other similar drugs have cumulative dose ranges above which most patients will be rendered infertile, but Shnorhavorian says population-based studies are needed to describe the prevalence of these effects in survivors of AYA malignancies.


'/>"/>

Contact: Frank DeSanto
fdesanto@umich.edu
734-998-0114
University of Michigan Health System
Source:Eurekalert

Related medicine news :

1. ASTRO names radiologist, ABR president Societys 2010 Honorary Member
2. Jackson Surgical Assistants Names Dr. Sidney Funk as Medical Director
3. More Big Names Line Up To Support Global Hearing Loss Awareness Initiative
4. San Antonio Business Journal Names BMI of Texas One of the Best Places to Work in San Antonio
5. National Leadership Program Names New Class of Fellows
6. Vietnamese Student Named UMass Boston JFK Award Winner
7. Leveragepoint Names Jay Manson Vice President Sales For Online Value Management Tools
8. CBCA Names Tim Reed as Vice President, Human Resources
9. Leading Industry Analyst Firm Names ActiveBase "Cool Vendor"
10. Locum Tenens Organization Names CompHealth Executive to Board of Directors
11. Outside Magazine Names LeBootCamp as One of America's Best Places to Work in 2010
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2016)... ... ... a crisis. Her son James, eight, was out of control. Prone to extreme mood shifts ... upset him, he couldn’t control his emotions,” remembers Marcy. “If there was a knife ... and say he was going to kill them. If we were driving on the ...
(Date:6/24/2016)... ... June 24, 2016 , ... Global law firm Greenberg Traurig, P.A. announced that ... chosen by their peers for this recognition are considered among the top 2 percent ... special honors as members of this year’s Legal Elite Hall of Fame: Miami ...
(Date:6/24/2016)... CA (PRWEB) , ... June 24, 2016 , ... Comfort ... the American Cancer Society and the Road To Recovery® program to drive cancer patients ... seniors and other adults to ensure the highest quality of life and ongoing independence. ...
(Date:6/24/2016)... ... June 24, 2016 , ... People across the U.S. ... magazine’s Code Talker Award, an essay contest in which patients and their families pay ... be presented at the 2016 National Society of Genetic Counselors (NSGC) Annual Education Conference ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... ... Living, is proud to recognize Dr. Barry M. Weintraub as a prominent plastic ... most beautiful women in the world, and the most handsome men, look naturally ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... Calif. , June 23, 2016 Any dentist ... many challenges of the current process. Many of them do ... of the technical difficulties and high laboratory costs involved. And ... to offer it at such a high cost that the ... it. Dr. Parsa Zadeh , founder of ...
(Date:6/23/2016)... startling report released today, National Safety Council research shows ... plan to eliminate prescription opioid overdoses. Prescription Nation ... the worst drug crisis in recorded U.S. history, assigned a "Making ... , New Mexico , Tennessee ... states, three – Michigan , Missouri ...
(Date:6/23/2016)... , June 23, 2016 Research ... MEMS Devices Medical Market Analysis 2016 - Forecast to 2022" ... The report contains up to date financial data ... analysis. Assessment of major trends with potential impact on the ... analysis of market segmentation which comprises of sub markets, regional ...
Breaking Medicine Technology: