Navigation Links
SUVmax provides valuable indicator of progression-free survival in stage I NSCLC patients

Orlando, Fla., February 8, 2013 SUVmax (Maximum Standardized Uptake Value) may be a significant and clinically independent marker to indicate progression-free survival in stage I non-small cell lung cancer (NSCLC) patients treated with stereotactic body radiation therapy (SBRT), according to research being presented at the 2013 Cancer Imaging and Radiation Therapy Symposium. This Symposium is sponsored by the American Society for Radiation Oncology (ASTRO) and the Radiological Society of North American (RSNA).

SUVmax is measured via PET/CT scan after patients have been injected with radioactive sugar (glucose). Quantifying the SUV of suspicious lesions can aid the identification of early stage tumors because cells that take in greater than normal amounts of radioactive glucose have a higher likelihood of being tumor cells. The highest concentration of radioactive glucose represents SUVmax. Previous studies have been able to correlate SUVmax to the growth rate of tumors, which indicates that tumors with higher SUVmax will more likely be more rapidly growing and will therefore be tumors that are more difficult to treat, may recur or may metastasize more frequently.

This study included 95 medically inoperable NSCLC patients from October 2005 through May 2011, with a median age of 77 years. All patients had peripheral tumors, and no patient had been previously treated for lung cancer. Prior to SBRT treatment, all patients had an PET/CT scan with documented pretreatment SUVmax assessment. SBRT fractionation was 60 Gy in three (3) fractions with a median treatment time of six days (range of three to 21 days). With a median follow-up of 15 months, median overall survival was 25.3 months and progression-free survival was 40.3 months. Tumor control, overall and progression-free survival were derived utilizing the Kaplan-Meier method, and Cox proportional hazards regression was performed to determine whether SUVmax, age, Karnofsky Performance Status, gender, tumor size/T-stage or smoking history influenced outcomes.

"If SUVmax is assessed prior to radiation therapy, specific strategies could be developed to tailor treatments for patients, which would, in turn, provide them with the best chance at a longer and disease-free survival," said Zachary Horne, a 2013 MD candidate at the George Washington University School of Medicine in Washington, D.C., the lead study author and a researcher in the radiation oncology department at the University of Pittsburgh Cancer Institute. "Accurate anatomical and functional imaging and assessment, such as SUVmax, can help us achieve improved outcomes for patients."


Contact: Michelle Kirkwood
American Society for Radiation Oncology

Related medicine news :

1. DAI provides potential imaging biomarker to indicate brain tumor response to RT
2. Premium Astrology Launches New Site -- Astro Answer -- Provides Support for Customer Service Satisfaction
3. Transvaginal Mesh Lawsuit Website Launched by Bernstein Liebhard LLP Provides Updated Information on Vaginal Mesh Side Effects, Growing Litigation
4. Expert Revivogen Provides Tips and Education to Prevent Hair Loss, Recommends Starting a Preventative Hair Loss Regimen to Stop the Condition Before it Advances
5. Hearing Aid Device Expert of Upstate Hearing Instruments Provides 7 Key Tips to Encourage Hearing Aid Adoption within the Elderly Populations
6. Medical cannabis provides dramatic relief for sufferers of chronic ailments
7. Xocai's New Xe Product Provides An Incentive For Marketing Xocolate International Corporation (MXI Corp) Distributors To Launch Their Business To A Whole New Level
8. LSUHSC research provides new drug target for Her-2 related breast cancer
9. Guided care provides better quality of care for chronically ill older adults
10. Director of the Center for Craniofacial & Dental Sleep Medicine Provides New Cutting Edge Technology for Patients Suffering with Obstructive Sleep Apnea
11. Pill-sized device provides rapid, detailed imaging of esophageal lining
Post Your Comments:
(Date:11/27/2015)... ... November 27, 2015 , ... According to an article ... American Dental Association meeting in Washington D.C. revolved around the fact that proper dental ... health. The talk stressed the link between periodontal disease (more commonly referred to as ...
(Date:11/27/2015)... , ... November 27, 2015 , ... ... safe and convenient way to dispense prescription medications at home, so he invented ... way to monitor and dispense prescription medications. In doing so, it could help ...
(Date:11/27/2015)... ... November 27, 2015 , ... MPWH, the No.1 Herpes-only dating community in the world, revealed ... 1-1 ). More than 3.7 billion people under the age of 50 – or ... to WHO's first global estimates of HSV-1 infection . , "The data shocks us ...
(Date:11/27/2015)... ... November 27, 2015 , ... ... innovative online platform for mental health and wellness consultation, has collaborated with a ... will bridge the knowledge gap experienced by parents and bring advice from parenting ...
(Date:11/27/2015)... ... 2015 , ... Indosoft Inc., developer and distributor of the ... LTS (Long Term Support) into its Q-Suite 5.10 product line. , Making the ... a version of Asterisk that will receive not only security fixes, but feature ...
Breaking Medicine News(10 mins):
(Date:11/29/2015)... 2015  The GE Health Cloud 1 was unveiled ... North America (RSNA) meeting in ... the new cloud ecosystem and its applications will connect radiologists ... and multidisciplinary teams – both inside and outside the hospital ... of GE. "As the digital industrial leader, we are betting ...
(Date:11/29/2015)... 29, 2015   National Decision Support Company (NDSC) ... base, including notable statewide implementations. As a result, ... ACR Select, more than 1 million times per ... ACR Select provides real-time feedback on the most ... has been implemented at over 100 healthcare systems ...
(Date:11/27/2015)... 27, 2015 --> ... go online. The potential to save costs, improve treatment ... far from fully exploited as yet. Here, particular emphasis ... either via mobile tablet or directly at the patients, ... ) -->      (Photo: ...
Breaking Medicine Technology: