Navigation Links
SU physicist develops model for studying tissue pattern formation during embryonic development
Date:9/25/2013

A team of scientists, including M. Lisa Manning, assistant professor of physics in Syracuse University's College of Arts and Sciences, has developed a model for studying tissuespecifically how it organizes into organs and layers during embryonic development.

Their findings are the subject of a Sept. 25th article in the journal Interface (Royal Society Publishing, 2013) and may have major implications for the study of tissue pattern formation and malformation.

Central to their work was the question of whether embryonic tissue behaves more like a solid or a liquidand why.

"We found that embryonic tissue was viscoelastic, meaning that it behaved like a liquid, if you pushed on it slowly, but like a solid, if you pushed on it quickly," says Manning, who co-wrote the article with Eva-Maria Schoetz, assistant professor of biology and physics at the University of California, San Diego; and Marcos Lanio and Jared Talbot, both researchers in Princeton University's Lewis-Sigler Institute for Integrative Genomics. "A mixture of cornstarch and water also behaves that way."

Manning and her team found that viscoelasticity was the result of "glassy dynamics" in cells, caused by overcrowding. They discovered that cells within embryonic tissue were packed so tightly that they rarely movedand when they did so, they expended considerable energy to squeeze past their neighbors.

She compares this behavior to riding on a subway. "If you're on a subway train that's not very crowded, it's easy to move toward the exit and get off the train," says Manning, an expert in theoretical soft condensed matter and biological physics. "But as more people get on the train, it takes longer to pick your way past them and exit. Sometimes, if the train is jam-packed, you miss your stop completely because you can't move at all."

Experimental and simulation data from Manning's experiment, in which two "droplets" of tissue join together, in a fluid-like manner, to form a single tissue.

Using state-of-the-art imaging and image analysis techniques, Manning and her team saw that each cell was crowded by what she calls a "cage of neighbors." A simple active-matter model, which they created, has enabled them to reproduce data and make predictions about how certain changes and mutations affect embryonic development.

"This is exciting because if cells slow down or generate more sticky molecules, the tissue can turn into a solid," says Manning, adding that such alterations can trigger malformations or congenital disease. "Our results provide a framework for understanding these changes."

Manning's work is rooted in that of another Princeton scientist, the late Malcolm Steinberg, who suggested more than 50 years ago that different types of embryonic tissue behave like immiscible liquids, such as oil and water. "[This liquid-like behavior] helps tissue separate into layers and form structures, including organs," says Manning, who joined SU's faculty in 2011, after serving as a postdoctoral fellow in the Princeton Center for Theoretical Science. "This type of work is fun because it involves knowledge from lots of disciplines, from soft-matter physics and materials science to cell and developmental biology."


'/>"/>

Contact: Keith Kobland
kkobland@syr.edu
315-443-9038
Syracuse University
Source:Eurekalert

Related medicine news :

1. Prominent Cedars-Sinai medical physicist receives highest honor from distinguished association
2. York physicists offer novel insight into experimental cancer treatment
3. UT Arlington physicists tool has potential for brain mapping
4. Seeing is believing: Biologists and physicists produce revealing images of cell organization, behavior
5. UCSC physicist Alexander Sher named Pew Scholar in the Biomedical Sciences
6. Inventor and InventHelp Client Develops Medical Accessory to Aid in Elderly Mobility (MMB-2107)
7. PeopleKeys Develops HR Filtering Tools in Response to Fewer Jobs, Increased Competition in Health Care
8. UPNA develops a method that automatically delimits areas of the brain in medical images
9. McKenzie Management Develops New Tool To Measure Hidden Revenue Potential
10. InventHelp® Client Develops Better Medical Valve (DVR-579)
11. Inventor and InventHelp Client Develops Improved Packaging Design for Bottles (SAH-240)
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/4/2016)... , ... December 03, 2016 ... ... Newall wins "Best Surgical Body Shaping" at the 2016 Anti-Aging & ... Paris, France. , The Aesthetic & Anti-Aging Medicine European Congress (AMEC) ...
(Date:12/4/2016)... ... , ... Responsible dental care hinges on regular brushing of the teeth. However, ... important necessity inspired an inventor from Las Vegas, Nev., to design the BRUSH PROPER. ... or avoid bad techniques of brushing the teeth in order to prevent cavities," he ...
(Date:12/2/2016)... ... ... twenty-four years, Doctors on Liens has published a directory of the top doctors ... When the company started in 1997, the directory was a single page focusing on ... ten-page directory features a vast array of medical specialists stretching from Sacramento to ...
(Date:12/2/2016)... ... , ... The annual time frame to change Medicare health and prescription drug ... 7th. Currently-enrolled Medicare beneficiaries who are looking to switch from their current plan to ... make changes during this period order for their new policy to go into effect ...
(Date:12/2/2016)... New York, NY (PRWEB) , ... December 02, 2016 , ... ... from high school and while 84 percent of parents report speaking with their child ... control, pornography and sexually transmitted diseases. , Mediaplanet is proud to announce the launch ...
Breaking Medicine News(10 mins):
(Date:12/2/2016)... Research and Markets has announced the addition of the "R&D ... ... R&D Drug Pipeline Database: 1-Year Subscription Subscription ... online access to information about more than 21,000 project entries (files) ... in research & development. Pre-established and free search ...
(Date:12/2/2016)... December 2, 2016 Persistence Market ... market in its upcoming report titled, "Global Market Study on Cardiac ... CAGR of -1.4% between 2016 and 2024". The global cardiac ... 2015 and this is likely to decline to US$ ... global cardiac pacemaker market is anticipated to exhibit a ...
(Date:12/2/2016)... DUBLIN , Dec 2, 2016 Research ... Market Size, Share, Development, Growth and Demand Forecast to 2022" report ... , , ... revenue of $6 billion in 2015, and it is expected to grow ... ultrasound segment is expected to witness faster growth during the forecast period, ...
Breaking Medicine Technology: