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SRI International Awarded a Department of Defense 'Laboratory-Clinical Transition' Grant to Advance SRI's Novel Anticancer Agents for Prostate Cancer Treatment
Date:10/13/2009

MENLO PARK, Calif., Oct. 13 /PRNewswire/ -- SRI International, an independent, nonprofit research and development organization, announced today that it has been awarded a $1.55M U.S. Department of Defense/Prostate Cancer Research Program (DoD/PCRP) grant to support product-driven, preclinical studies of SRI's novel agents that have the potential to become prostate cancer drugs. The goal of the program is to discover treatments that can revolutionize the prevention, detection, or treatment of prostate cancer.

Prostate cancer is the most commonly diagnosed cancer in men and second only to lung cancer as a leading cause of cancer deaths in men. There is currently no cure for advanced or metastatic prostate cancer. The available treatments for localized prostate cancer often leave patients with uncertainty about disease recurrence and complications such as incontinence or impotence. SRI researchers are working to develop an effective and well-tolerated therapy that improves prospects for a cure without impairing overall well-being.

With support from an earlier DoD/PCRP Idea Development Award, SRI researchers developed a novel class of anticancer drugs derived from dietary indoles found in cruciferous vegetables that prevent prostate tumor cell proliferation, progression, and invasion. The novel lead compound, SR13654, shows antitumor activity and disease control with few side effects at efficacious doses. Early preclinical safety studies indicate that this class of bis-indole compounds holds potential to be better tolerated than many anticancer agents currently on the market.

"This award will support SRI's efforts to continue the research and development of SRI's advanced lead, which holds promise for the treatment and prevention of prostate cancer," said Ling Jong, Ph.D., principal investigator and medicinal chemistry program director in SRI's Center for Cancer Research. "The successful development of this class of drug will fi
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SOURCE SRI International
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