Navigation Links
SNPs of ABC transporter genes linked to lung cancer risk
Date:12/21/2008

Individuals with particular variants of certain genes involved in metabolizing the most potent carcinogen found in cigarette smoke have an increased risk of developing lung cancer. That is the conclusion of a new study published in the February 1, 2009 issue of CANCER, a peer-reviewed journal of the American Cancer Society. The study's results may help shed light on how lung cancer develops and could have important implications for preventing smoking-related cancers.

Tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is a component of cigarette smoke that has been shown to cause lung cancer in rodents. Certain enzymes act to protect the body from this type of chemical by turning it into nontoxic forms or by transporting it from cells. For example, ATP-binding cassette transporters encoded by genes known as ABCB1 and ABCC1 are involved in eliminating carcinogens from the lungs, protecting them against inhaled toxins.

Researchers suspect that individuals with alterations in these genes might have an increased susceptibility to develop lung cancer. Recently, a team of scientists led by Dr. Daru Lu and Dr. Haijian Wang of the Fudan University in Shanghai identified common variants at the beginning and end of the ABC1 and ABCC1 genes. They then analyzed these variants in 500 patients with lung cancer and 517 cancer-free controls in a Chinese population.

The investigators found that certain variants were found much more often in individuals with lung cancer than in cancer-free controls. Patients who had the variant allele of either ABCB1 rs3842 or ABCC1 rs212090 had a significantly increased risk of developing lung cancer. The former variant was particularly associated with an increased risk of cancer in women and in individuals under age 60 years. It also was linked to a major type of lung cancer called adenocarcinoma.

Dr. Wang and his colleagues previously identified other common genetic variants associated with lung cancer risk in NNK disposition pathways, such as CYP2A13, the most active P450 for the phase metabolic activation of NNK (Cancer Res 2003; 63: 8057) and the receptor (ADRB2) in its non-genotoxic pathway (Cancer Lett 2006; 240: 297). This study shed new insight into the toxicogenomics of NNK and further supported the hypothesis proclaiming genetic components in the metabolism and disposition machines of NNK as modifiers of risk of lung cancer.

"Because tobacco smoking is the leading preventable cause of cancer and the cancer-prone genotypes of these genetic components are relatively prevalent in the human population, our findings have important implications for the prevention of tobacco smokingrelated cancers," the authors write.


'/>"/>

Contact: David Sampson
david.sampson@cancer.org
American Cancer Society
Source:Eurekalert

Related medicine news :

1. Transporters may help delay diabetes-related retinal damage
2. ThermoGenesis Introduces New Cell Separation Technology for Veterinary Use at Major Equine Convention
3. 11 New Cholesterol Genes Identified
4. Few Ontario women with invasive ovarian cancer referred for genetic testing of breast cancer genes
5. ThermoGenesis Corp. Provides Updated Information for Conference Call/Webcast to Discuss Management Transition
6. ThermoGenesis Corp. Schedules Conference Call/Webcast to Discuss Management Transition
7. ThermoGenesis Announces Management Transition; Provides Update on Operational Milestones
8. Organogenesis Receives Two Prestigious Awards for Economic Impact and Manufacturing Excellence
9. China West II Files Suit Against Genesis Pharmaceuticals and Capital Research Group Inc, Announces Conference Call Details
10. Genes May Predict Lymphoma Treatment Outcome
11. Researchers ID Suite of Genes in Aging Process
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2017)... , ... June 27, 2017 , ... Today, June 27th ... from PTSD. Yet less than 20% will receive adequate care due to lack of ... won't receive any care at all. And left untreated, veterans are at an increased ...
(Date:6/26/2017)... ... 2017 , ... Antoine Dental Center is now offering various types of dental implants ... as a support for prosthetic teeth, such as crowns, bridges, or dentures. An implant is ... sturdy, lasting new root for the tooth. , Several types of dental implants are ...
(Date:6/26/2017)... , ... June 26, 2017 , ... LARKR™ , ... health professionals in every state across the country to join its online treatment platform. ... way for therapists to reach a substantially greater number of people in need nationwide, ...
(Date:6/25/2017)... ... June 24, 2017 , ... Create a feel-good lyric music video in Final Cut Pro X ... the timeline and write in the lyrics to any song. ProLyric flies in the text ... of the text can be added modularly for optimal control. ProLyric makes editing any music ...
(Date:6/25/2017)... ... ... Health Month and the focus is on prostate cancer. Second only to skin cancer, ... most common cause of cancer related death today; lung cancer remains in the number one ... cancer during his lifetime. Those at highest risk are men who have a ...
Breaking Medicine News(10 mins):
(Date:6/8/2017)... 8, 2017  StatLab Medical Products ("StatLab" ... manufacturer of diagnostic supplies for the anatomic ... & Company LP ("Cressey & Company"), a ... growth-focused investment in the Company. Cressey & ... from selling shareholder, Prairie Capital, L.P., with ...
(Date:6/5/2017)... June 5, 2017 Kohll,s Pharmacy & Homecare is the ... the United States . The Raizer is a simple ... person up to an almost-standing position within a ... by one assistant and does not require any ... that a child can operate it, and lightweight ...
(Date:5/30/2017)... CHICAGO , May 30, 2017 Hill-Rom Holdings, ... th Annual Global Healthcare Conference on Tuesday, June 13, ... John Greisch , Hill-Rom,s president and chief executive officer, ... The live audio webcast can be accessed at ... after conclusion of the live event through September 13, 2017. ...
Breaking Medicine Technology: