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SNPs associated with breast cancer risk alter binding affinity for pioneer factor FOXA1
Date:1/23/2013

porting regulatory mechanisms for GWAS-identified risk-associated SNPs is steadily growing. Heterozygous sites with differential allelic occupancy within 100 bp of transcription start sites have been shown to have a strong association with differential gene expression and to be enriched for GWAS-identified SNPs31. Binding of the FOXA1 pioneer factor is central for chromatin opening and nucleosome positioning favorable to transcription factor recruitment. In addition, FOXA1 is central to the establishment of the transcriptional programs that respond to estrogen stimulation in ESR1-positive breast cancer cells.


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Contact: Donna M. Dubuc
donna.m.dubuc@hitchcock.org
603-653-3615
Dartmouth-Hitchcock Medical Center
Source:Eurekalert

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