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SLU virologists harness adenovirus to kill breast cancer cells
Date:5/23/2014

ression of these 80 amino acids efficiently represses HER2 transcription and kills breast cancer cells but not normal cells.

"This is probably due to the need of the tumor cells for continued overexpression of the HER2 oncogene for growth and survival. This phenomenon has been termed 'oncogene addiction,'" Green said.

One of the exciting possibilities of E1A 1-80 is that it seems to be effective against cancer cells over-expressing other HER family members, besides HER2. Potentially, E1A 1-80 could be used against tumors of the prostate, ovaries, colon, and head and neck, as well as breast cancer.

With this grant, Green and Loewenstein want to develop a strong E1A 1-80 HER2 repressor that may someday be added to Herceptin therapy. Their work will include animal model studies to further demonstrate the potential of E1A 1-80 as a therapy.

And, Green sees particular promise in this gene therapy because it seems to kill not only tumor cells, but targets their origins, as well.


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Contact: Carrie Bebermeyer
bebermcl@slu.edu
314-977-8015
Saint Louis University
Source:Eurekalert  

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