Navigation Links
SIRT1 gene important for memory
Date:7/22/2010

A protein implicated in many biological processes also may play a role in memory, according to a study led by the University of Southern California and the National Institute on Aging at the National Institutes of Health.

The findings, published this week in the Journal of Neuroscience, agree with research by a different team published online by Nature on July 11. Both studies found that mice lacking the protein SIRT1 exhibited impaired memory and learning, suggesting SIRT1's importance to those functions.

However, the new study also found that boosting natural levels of SIRT1 protein did not improve learning or memory in the mice, raising questions about the case for supplementing a normal diet with sirtuin activators, a family of compounds targeted to activate SIRT1.

"The over-expression of SIRT1 did not improve memory, implying that increasing the amount of the protein may not enhance memory. Many more studies with different models are necessary, however, to rule this out," said co-corresponding author Valter Longo, a molecular biologist in the USC Leonard Davis School of Gerontology with a joint appointment in the USC College of Letters, Arts and Sciences.

In mice, sirtuins have been shown to affect metabolism and other biological processes involved in aging. A number of studies have shown that resveratrol, a proposed sirtuin activator and much-advertised "anti-aging" ingredient in red wine, has beneficial effects on some aspects of health, though it does not prolong life in normal mice. However, it does improve the health and extends the life span of mice on a high fat diet.

The physiological functions of sirtuins in humans are under intense investigation, with many ongoing studies on the effects of sirtuin activators and inhibitors on various diseases.

"This is a very controversial topic since sirtuins have been shown to be both good and bad," Longo noted. "In our previous studies [in mice and
'/>"/>

Contact: Carl Marziali
marziali@usc.edu
213-740-4751
University of Southern California
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Launch of On Time Air Filters: Home Air Filter Delivery Service Helps Homeowners Replace All-Important Home HVAC Filters On Time
2. Mayo Clinic researchers find oncogene is important in pancreatic cancer growth and spread
3. NORD Calls FDA Action An Important Advance for Patients
4. Galfand Berger Wins Important Case for Injured Workers in Pennsylvania
5. Author Proves What Celebrities are Learning in "Who Do You Think You Are?" is More Important Than They Realize
6. Frances national program to reduce HAIs reports important successes; uses mandatory reporting
7. A Monumentally Important Victory for Our Country
8. Recurrence of breast cancer after more than 10 years is an important indicator of survival
9. VA Proposes Important Amendment to Expand Healthcare for Veterans
10. Teaching medicine series covers the most important topics in medical education
11. LocumTenens.com Offers Important Tax Tips for 1099 Workers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/12/2014)... News) -- Burn injuries increase in the summer as people ... experts. Among those most vulnerable to these seasonal fire hazards: ... often get burned by putting their hands on the side ... burn unit at Loyola University Medical Center in Maywood, Ill., ... of ,When you play with fire, you get burned, is ...
(Date:7/12/2014)... “After my mom’s stroke, she loss the use ... loss the use of his left side. Eating became a difficult ... help people like them enjoy eating again,” said an inventor, from ... PATRICIA CAROL HALL PLATE (P C H PLATE). , The PATRICIA ... way to eat for individuals who suffer from stroke, experience tremors ...
(Date:7/12/2014)... With prom shopping reaching its final ... is ready to showcase its new and trendy apparels. ... evening dresses in its online shop. Additionally, it is ... these elegant gowns. According to the company’s sales manager, ... 26, 2014. , He says, “Now, worldwide clients ...
(Date:7/12/2014)... Albany, NY (PRWEB) July 12, 2014 ... to 2020 - New and Late-Stage Four-Factor PCCs ... in-depth analysis of the critical care market in ... and Canada. The report provides an estimation of ... to 2020. It covers critical care indications that ...
(Date:7/12/2014)... City, Utah (PRWEB) July 12, 2014 ... two types of startups, with awards being bestowed to ... emphasis spotlighted Utah’s outstanding entrepreneur community with recognition for ... a sustainable model with incoming revenue. , 25 Under ... across the state that are under 5 years old. ...
Breaking Medicine News(10 mins):Health News:Burn Injuries More Common in Summer 2Health News:VogueQueen.com Updates Its Summer Collection With New And Trendy Evening Dresses 2Health News:Critical Care Therapeutics in Major Developed Market is Expected to Grow at a CAGR of 4.7% to $2.5 Billion in 2019 2Health News:Critical Care Therapeutics in Major Developed Market is Expected to Grow at a CAGR of 4.7% to $2.5 Billion in 2019 3Health News:Critical Care Therapeutics in Major Developed Market is Expected to Grow at a CAGR of 4.7% to $2.5 Billion in 2019 4Health News:Critical Care Therapeutics in Major Developed Market is Expected to Grow at a CAGR of 4.7% to $2.5 Billion in 2019 5Health News:Critical Care Therapeutics in Major Developed Market is Expected to Grow at a CAGR of 4.7% to $2.5 Billion in 2019 6Health News:SquareHook is Recognized for UVEF 25 Businesses Under 5 Years-Watch Out 2
... , WASHINGTON, Aug. 26 Danaher Corporation ... Executive Officer, H. Lawrence Culp, Jr. will be presenting at ... on Wednesday, September 2, 2009 at 12:30 p.m. EDT. The ... the webcast will be available for one week following the ...
... , MCLEAN, Va., Aug. 26 MicroStrategy((R)) ... provider of business intelligence (BI) software, today announced that ... has selected MicroStrategy to improve its sales reporting and ... international pharmaceuticals company Boehringer Ingelheim. , , ...
... , MISSION, Kan., Aug. 26 Like ... new ways to operate cost-effectively and use tax dollars wisely. ... administration program. And effective October 2009, Kansas City-based COBRAGuard, Inc. ... , Of course, with every outsourcing situation, ...
... ... anti-aging . , ... -- Every morning women all across America wake up, head to the makeup mirror, and add ... is hailed by Allure magazine as one of the most influential beauty breakthroughs of the decade, ...
... , , NEW YORK, Aug. 26 ... applied to the government broadband stimulus fund to provide broadband access ... areas exist in all 50 states because they are not connected ... or too disperse and challenging to dig ditches and lay wires. ...
... , SOUTHAMPTON, Pa., Aug. 26 ... the "Company") BioMedical Systems Division, a product division in ... SRL for the delivery and installation of the first ... , Histria International is a "turn-key" ...
Cached Medicine News:Health News:Boehringer Ingelheim's Swiss Branch Improves Sales Reporting and Efficiency with MicroStrategy Software 2Health News:Boehringer Ingelheim's Swiss Branch Improves Sales Reporting and Efficiency with MicroStrategy Software 3Health News:State of Kansas Streamlines COBRA Administration With Innovative Web-Based Solution 2Health News:5 Simple Ways to Take 10 Years Off Your Face 2Health News:5 Simple Ways to Take 10 Years Off Your Face 3Health News:5 Simple Ways to Take 10 Years Off Your Face 4Health News:01 Data Center Applied to Provide Broadband Access to Healthcare Facilities in Unserved Areas 2Health News:Environmental Tectonics Corporation's BioMedical Systems Division Announces First BARA-MED(R) Monoplace Hyperbaric Chamber Sale in Romania 2Health News:Environmental Tectonics Corporation's BioMedical Systems Division Announces First BARA-MED(R) Monoplace Hyperbaric Chamber Sale in Romania 3Health News:Environmental Tectonics Corporation's BioMedical Systems Division Announces First BARA-MED(R) Monoplace Hyperbaric Chamber Sale in Romania 4
(Date:7/11/2014)... , July 11, 2014 Research and ... "Global and Chinese Medical X-ray Film Industry Report 2014" ... http://photos.prnewswire.com/prnh/20130307/600769 Global And Chinese Medical ... in-depth study on the current state of the Global ... Chinese situation. The report provides a basic overview ...
(Date:7/11/2014)... July 11, 2014  Kindred Hospital Houston Northwest, ... the opening of its new outpatient wound healing ... to people with chronic, hard to heal wounds. ... lead to amputation, lower leg wounds related to ... closure, and traumatic injury wounds which are complex ...
(Date:7/11/2014)... ALBANY, New York , July 11, 2014 /PRNewswire/ ... published by Transparency Market Research "Endoscopy Devices Market (Endoscopes, ... Analysis, Size, Share, Growth, Trends and Forecast, 2013-2019" the ... billion in 2012 and is expected to grow at ... reach an estimated value of USD 36.9 billion in ...
Breaking Medicine Technology:Global and Chinese Medical X-ray Film Industry Report 2014 2Kindred Hospital Houston Northwest, With Wound Care Specialists, Opens Outpatient Wound Healing And Hyperbaric Center 2Global Endoscopy Devices Market is Expected to Reach USD 36.9 Billion by 2019: Transparency Market Research 2Global Endoscopy Devices Market is Expected to Reach USD 36.9 Billion by 2019: Transparency Market Research 3Global Endoscopy Devices Market is Expected to Reach USD 36.9 Billion by 2019: Transparency Market Research 4Global Endoscopy Devices Market is Expected to Reach USD 36.9 Billion by 2019: Transparency Market Research 5Global Endoscopy Devices Market is Expected to Reach USD 36.9 Billion by 2019: Transparency Market Research 6
... 2011 /PRNewswire-iReach/ -- In the world of veterinary ... is a 1 in 9 chance of anesthetic complications and ... cats. It is with great pride that LEI Medical ... history; having never had a single, equipment-related animal death reported. ...
... Medical Inc., a leader in developing minimally invasive medical ... tissue from the gastrointestinal tract, announces today that they ... Covidien.  Covidien is a leading global provider of healthcare ... Covidien will acquire all of the ...
Cached Medicine Technology:LEI Medical Emerges as an Innovator and Leads the Way in Safety 2LEI Medical Emerges as an Innovator and Leads the Way in Safety 3BARRX Medical, Inc. Announces Definitive Agreement to be Acquired by Covidien 2BARRX Medical, Inc. Announces Definitive Agreement to be Acquired by Covidien 3
For implantation in proximal interphalangeal joints of the lateral toes to correct deformity associated with degenerative or rheumatoid arthritis....
Part of the GraFix® Cruciate Reconstruction System, which is designed to facilitate arthroscopic anterior cruciate ligament reconstructions....
... a new standard in the field of hammertoe ... Made of medical grade silicone, these durable and ... high level of flexibility while maintaining correct toe ... in varying stiffnesses. Lengths are determined by the ...
... Kinetik Great Toe Implant (KGTI) system offers ... of the first MPJ. The implant system ... of motion. , ,The KGTI is the ... metatarsophalangeal joint (MPJ) on the market today. ...
Medicine Products: