Navigation Links
SIRT1 gene important for memory
Date:7/22/2010

A protein implicated in many biological processes also may play a role in memory, according to a study led by the University of Southern California and the National Institute on Aging at the National Institutes of Health.

The findings, published this week in the Journal of Neuroscience, agree with research by a different team published online by Nature on July 11. Both studies found that mice lacking the protein SIRT1 exhibited impaired memory and learning, suggesting SIRT1's importance to those functions.

However, the new study also found that boosting natural levels of SIRT1 protein did not improve learning or memory in the mice, raising questions about the case for supplementing a normal diet with sirtuin activators, a family of compounds targeted to activate SIRT1.

"The over-expression of SIRT1 did not improve memory, implying that increasing the amount of the protein may not enhance memory. Many more studies with different models are necessary, however, to rule this out," said co-corresponding author Valter Longo, a molecular biologist in the USC Leonard Davis School of Gerontology with a joint appointment in the USC College of Letters, Arts and Sciences.

In mice, sirtuins have been shown to affect metabolism and other biological processes involved in aging. A number of studies have shown that resveratrol, a proposed sirtuin activator and much-advertised "anti-aging" ingredient in red wine, has beneficial effects on some aspects of health, though it does not prolong life in normal mice. However, it does improve the health and extends the life span of mice on a high fat diet.

The physiological functions of sirtuins in humans are under intense investigation, with many ongoing studies on the effects of sirtuin activators and inhibitors on various diseases.

"This is a very controversial topic since sirtuins have been shown to be both good and bad," Longo noted. "In our previous studies [in mice and mammalian cells], for example, we showed that it was the absence of SIRT1 that protected neurons.

"So maybe there is a trade-off between protection against toxicity and function such as that which is essential for learning and memory."

In the Longo group's study, mice missing the SIRT1 gene not only had cognitive problems, but also physical defects in their neural networks. The neurons of such mice had simpler structures with less branching and complexity indicators of a decreased ability to learn and adapt.

At the other end, mice engineered to over-express the SIRT1 gene performed no better on learning and memory tests than normal mice. Their brains did not show any adverse physical characteristics.


'/>"/>

Contact: Carl Marziali
marziali@usc.edu
213-740-4751
University of Southern California
Source:Eurekalert

Related medicine news :

1. Launch of On Time Air Filters: Home Air Filter Delivery Service Helps Homeowners Replace All-Important Home HVAC Filters On Time
2. Mayo Clinic researchers find oncogene is important in pancreatic cancer growth and spread
3. NORD Calls FDA Action An Important Advance for Patients
4. Galfand Berger Wins Important Case for Injured Workers in Pennsylvania
5. Author Proves What Celebrities are Learning in "Who Do You Think You Are?" is More Important Than They Realize
6. Frances national program to reduce HAIs reports important successes; uses mandatory reporting
7. A Monumentally Important Victory for Our Country
8. Recurrence of breast cancer after more than 10 years is an important indicator of survival
9. VA Proposes Important Amendment to Expand Healthcare for Veterans
10. Teaching medicine series covers the most important topics in medical education
11. LocumTenens.com Offers Important Tax Tips for 1099 Workers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/10/2016)... ... 2016 , ... Emergency rooms provide emergency care to stabilize critical health issues, ... with dental emergencies at risk of losing a tooth or their smiles. Dr. Marine ... Common dental emergencies include:, , Avulsed or knocked-out teeth , ...
(Date:2/10/2016)... ... February 10, 2016 , ... Ongoing news of the ... Care Association™ (ALCA) to conduct a survey that takes a closer look at cases ... illustrates the prevalence and causes of TBI among the aging population, and identifies the ...
(Date:2/10/2016)... ... , ... AxoGen, Inc. (NASDAQ: AXGN), a leading medical technology company focused on ... year ended December 31, 2015 on Monday, February 29, 2016 after the market closes. ... following the release at 4:30 PM ET. Investors interested in participating by phone are ...
(Date:2/10/2016)... ... 2016 , ... For additional information contact Phyllis Strupp 480-488-5858 , Brain improves ... The Ultimate Guide to Brain Training" by award-winning author Phyllis Strupp explains ... is March 16, 2016. A free review copy is available to the media ...
(Date:2/10/2016)... ... February 10, 2016 , ... IDEX Health & Science, ... stainless steel (PLS) columns combine the strength of traditional stainless steel with the ... biological samples while operating at ultra-high pressures of 20,000 psi. The higher operating ...
Breaking Medicine News(10 mins):
(Date:2/10/2016)... , Feb. 10, 2016  The Baylor ... received an in-kind gift from ... VeinViewer® Vision vein finder for the nursing ... students as they learn how to start ... with traditional technique. ...
(Date:2/10/2016)... , Feb. 10, 2016  LexisNexis® Risk ... technology, today announced the launch of LexisNexis ... solution that helps improve and optimize the quality ... of performance using severity-adjusted scores. By measuring provider ... critical solution to deliver better outcomes, improve the ...
(Date:2/10/2016)... 10, 2016 Convergence scenarios are ... various technologies that results in diverse solutions ... opportunities create a cyclical system where technology ... the development of new technologies. ... technology convergences, which are constantly fostering new ...
Breaking Medicine Technology: