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SIMPONI(TM) (golimumab) Receives FDA Approval as First Once-Monthly Anti-TNF for Treatment of Rheumatoid Arthritis, Psoriatic Arthritis and Ankylosing Spondylitis
Date:4/24/2009

href="http://www.arthritis.org/disease-center.php?disease_id=31" target="_new">Arthritis Foundation.

Psoriatic arthritis is a chronic inflammatory disease that causes joint pain and swelling and can lead to joint destruction. Psoriatic arthritis is frequently associated with inflamed, scaly, red patches of skin psoriasis and nail psoriasis. According to the National Psoriasis Foundation, up to 30 percent of people with psoriasis also develop psoriatic arthritis. For additional information visit the National Psoriasis Foundation.

Ankylosing spondylitis is a painful and progressive form of spinal arthritis. In severe cases, the disease can result in fusing of the spinal vertebrae and cause structural damage to hips and other joints. An estimated 500,000 people in the U.S. are living with ankylosing spondylitis. For more information visit the Spondylitis Society of America.

About SIMPONI (golimumab)

SIMPONI is a human monoclonal antibody that targets and neutralizes excess TNF-alpha, a protein that when overproduced in the body due to chronic inflammatory diseases can cause inflammation and damage to bones, cartilage and tissue. The first once-monthly subcutaneous anti-TNF-alpha therapy, SIMPONI is approved for the treatment of moderately to severely active rheumatoid arthritis, active psoriatic arthritis and active ankylosing spondylitis, and is available either through the SIMPONI SmartJect autoinjector or a prefilled syringe. SIMPONI is also being studied as an intravenous infusion therapy for the treatment of rheumatoid arthritis. For more information about SIMPONI, visit www.SIMPONI.com.

In March 2008, Centocor Ortho Biotech I
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