Navigation Links
SIBLING proteins may predict oral cancer
Date:2/23/2010

AUGUSTA, Ga. The presence of certain proteins in premalignant oral lesions may predict oral cancer development, Medical College of Georgia researchers said.

SIBLINGs, or Small Integrin-Binding Ligand N-linked Glycoproteins, are a family of five proteins that help mineralize bone but can also spread cancer. SIBLINGs have been found in cancers including breast, lung, colon and prostate.

"Several years ago we discovered that three SIBLINGsosteopontin, bone sialoprotein and dentin sialophosphoproteinwere expressed at significantly high levels in oral cancers," said Dr. Kalu Ogbureke, an oral and maxillofacial pathologist in the MCG School of Dentistry. "Following that discovery, we began to research the potential role of SIBLINGs in oral lesions before they become invasive cancers."

The study, published online this week in the journal Cancer, examined 60 archived surgical biopsies of precancerous lesions sent to MCG for diagnosis and the patients' subsequent health information. Eighty-seven percent of the biopsies were positive for at least one SIBLING proteinwhich the researchers discovered can be good or bad, depending on the protein. For instance, they found that the protein, dentin sialophosphoprotein, increases oral cancer risk fourfold, while bone sialoprotein significantly decreases the risk.

"The proteins could be used as biomarkers to predict [the potential of a lesion to become cancerous]," said Dr. Ogbureke, the study's lead author. "That is very significant, because we would then be in a position to modify treatment for the individual patient's need in the near future."

Precancerous oral lesions, which can develop in the cheek, tongue, gums and floor and roof of the mouth, are risk factors for oral squamous cell carcinoma, which accounts for over 95 percent of all oral and pharyngeal cancers. Oral cancer, the sixth most common cancer in the world, kills about 8,000 Americans annually, Dr. Ogbureke said.

Treatment has been stymied up to this point because of clinicians' inability to predict which lesions will become cancerous. Surgery is standard for oral cancer, but treatment methods vary for precancerous lesions.

"When we treat these lesions now, there's an implied risk of under- or over-treating patients," Dr. Ogbureke said. "For example, should the entire lesion be surgically removed before we know its potential to become cancer, or should we wait and see if it becomes cancer before intervening?"

Further complicating the matter is that the severity of dysplasia, or abnormal cell growth, in a lesion can be totally unrelated to cancer risk. Some mild dysplasias can turn cancerous quickly while certain severe dysplasias can remain harmless indefinitely. The protein findings, which help eliminate the guesswork in such cases, "are fundamental," Dr. Ogbureke said. "If we're able to recognize these lesions early and biopsy them to determine their SIBLING profile, then oral cancer could be preventable and treatable very early."

Dr. Ogbureke's next step is to design a multi-center study that incorporates oral cancer risk factors, such as smoking and alcohol consumption, to further investigate their relationship with SIBLING protein expression.


'/>"/>

Contact: Paula Hinely
phinely@mcg.edu
706-721-3646
Medical College of Georgia
Source:Eurekalert  

Related medicine news :

1. Aggression in adolescents is influenced by siblings
2. Siblings Often Share Heart Risks
3. Parents show bias in sibling rivalry, says study
4. Siblings of schizophrenia patients display subtle shape abnormalities in brain
5. Texas Siblings Share Epilepsy Message on Capitol Hill
6. Siblings target of intervention program
7. Study finds increased sibling risk of obstructive sleep apnea in children
8. Bullies May Intimidate Siblings, Too
9. Penn study finds pro-death proteins required to regulate healthy immune function
10. Heat shock proteins are co-opted for cancer
11. Loss of gene leads to protein splicing and buildup of toxic proteins in neurons
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
SIBLING proteins may predict oral cancer
(Date:9/19/2017)... ... September 19, 2017 , ... Trusted debt-reduction firm CreditAssociates, LLC has announced two ... in excess of $835 million in resolved debt for its clients. , Credit card ... of the categories of debt settled by the company. With more than a decade ...
(Date:9/19/2017)... ... September 19, 2017 , ... ... Canyon Ranch to its recently formed Corporate Roundtable, a group of ... system and a sustainable world. , Canyon Ranch is a unique collection of ...
(Date:9/19/2017)... RESTON, VA (PRWEB) , ... ... ... future of medication management to the present, Mirixa Corporation recently unveiled the ... has continually redefined and reinvented how medication management services are delivered. Based ...
(Date:9/19/2017)... (PRWEB) , ... September 19, 2017 , ... Driving Dynamics ... Safety Training Company by Training Industry Inc. as part of its mission to continually ... , Selection to the first annual 2017 Top 20 Health and Safety Training Companies ...
(Date:9/19/2017)... ... September 19, 2017 , ... ... neurosurgeon, has received a big bump in sales after recently going live ... available on the Wal-Mart Stores-owned Jet.com, StackedNutrtion.com, RonnieColemanNutrition.com, RevNutrition.com and Go4ItNutrition.com. ...
Breaking Medicine News(10 mins):
(Date:8/29/2017)... 2017 ivWatch, LLC, the leading provider of continuous monitoring ... has been awarded an Innovative Technology contract from Vizient, Inc., the ... ... in the early detection of peripheral IV infiltration and extravasation events ... The Innovative Technology contract was awarded to ...
(Date:8/28/2017)... division of LightScalpel ®, LLC, is announcing its new line of ... American veterinary laser surgery innovation, Aesculight® is revolutionizing veterinary laser surgery once ... ... VetScalpel laser. Dr. Duclos practices veterinary dermatology at the Animal Skin and ... ...
(Date:8/24/2017)... -- BioBridges, a Career Portfolio® Management company providing integrated ... announce its corporate sponsorship of the upcoming fourth annual ... event will benefit charitable foundations affiliated with each band. ... to return once again as a sponsor of the ... Jason Falchuk , BioBridges Founding Partner. "Our life sciences ...
Breaking Medicine Technology: