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SGX Pharmaceuticals BCR-ABL Program to be Presented at the American Society of Hematology 49th Annual Meeting and Exposition
Date:12/6/2007

Date: Monday, December 10, 2007 from 1:30pm - 3:00pm EST

Session Type: Oral Session

Abstract: #535

Title: "SGX70393 Inhibits BCR-ABL & T315I In Vitro and In Vivo

and Completely Suppresses Resistance When Combined with

Nilotinib or Dasatinib."

Description: An oral presentation, coauthored with collaborators at the

Oregon Health & Science University Cancer Institute,

describes a proof of principle study demonstrating the

potential of combination targeted therapy for CML. SGX393

(also known as SGX70393) is a potent, selective

orally-bioavailable inhibitor of both wild type and major

drug resistant mutant forms of BCR-ABL, including the most

challenging T315I mutation.

"These two ASH presentations explain how SGX is using its

drug discovery platform to discover and optimize potent,

selective and orally-bioavailable inhibitors of important

oncology drug discovery targets," said Stephen Burley,

Chief Scientific Officer of SGX Pharmaceuticals.

"Moreover, the results obtained with our collaborators at

the Oregon Health & Science University Cancer Institute

demonstrate the potential of targeted combination therapy

for CML. A number of influential thought leaders believe

that effective management of newly-diagnosed CML will

depend on long-term treatment with multiple agents

possessing non-overlapping resistance profiles."

About the SGX BCR-ABL Program

SGX393 is an internally developed, orally-bioavailable, small molecule inhibitor of the abnor
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SOURCE SGX Pharmaceuticals, Inc.
Copyright©2007 PR Newswire.
All rights reserved

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