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SGX Pharmaceuticals BCR-ABL Program to be Presented at the American Society of Hematology 49th Annual Meeting and Exposition
Date:12/6/2007

SAN DIEGO, Dec. 6 /PRNewswire-FirstCall/ -- SGX Pharmaceuticals, Inc. (Nasdaq: SGXP) announced today details of two presentations from the Company's BCR-ABL program for the treatment of chronic myelogenous leukemia (CML) at the upcoming American Society of Hematology's 49th Annual Meeting and Exposition. The conference is being held December 8th - 11th, 2007 in Atlanta, Georgia.

The schedule for these sessions, together with the abstract information, is listed below:

Date: Saturday, December 8, 2007 from 5:30pm - 7:30pm EST

Session Type: Poster Session, Board #172-I

Abstract: #1018

Title: "Co-Crystal Structures of 7-Azaindole Inhibitors of

Wild-Type and T315I Imatinib-Resistant Mutant Forms of the

BCR-ABL Tyrosine Kinase."

Description: This poster presentation describes how the SGX393 chemical

family of BCR-ABL inhibitors discovered by SGX can provide

potent, selective inhibition of both wild type and major

drug resistant mutant forms of BCR-ABL including T315I.

The poster discusses the impact of seven BCR-ABL mutations

on the co-crystal structures of the SGX393 family of

inhibitors, including the challenging T315I, G250E and

F317L mutations. SGX393 represents an illustrative example

of how the integrated SGX FAST fragment-based,

structure-guided drug discovery platform can be used to

generate high-quality, low molecular weight inhibitors of

oncology targets.
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SOURCE SGX Pharmaceuticals, Inc.
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