Navigation Links
SFU duo's protein discovery links to cancer research
Date:7/26/2012

A Simon Fraser University graduate student's collaboration with her thesis supervisor on how a particular type of protein controls the growth of another protein could advance cancer research.

Their findings have just been published in the online July 26 issue of Current Biology, a CellPress journal.

Esther Verheyen, an SFU professor of molecular biology and biochemistry, has helped her Master's of Science student Joanna Chen uncover how Hipk can be manipulated to stop Yorkie from causing tissue overgrowth in flies.

Hipk is a protein kinase a type of enzyme that controls the activity of other proteins by depositing a phosphate residue on them.

Yorkie, known as Yap in humans, is another type of protein that induces the overgrowth of cell tissue in the eyes, legs and wings of flies. High levels of Yap are often found in human tumours.

In experiments on the fruit fly Drosophila, Verheyen and Chen first found that Hipk could cause overgrowths similar to those found on tissue with too much Yorkie.

The researchers then genetically generated flies in which there was a higher concentration of Yorkie but a lower concentration of Hipk present than normal in their organ and limb tissues.

"When we did that," says Chen, "Yorkie could not cause overgrowths anymore. We were able to show this need for Hipk to be present in a number of different fly tissues, such as the eyes, legs and wings."

"We found that Hipk could add a phosphate residue on Yorkie and we thought this might explain how Hipk could disrupt Yorkie's ability to cause an overgrowth," adds Verheyen. "This is a very common and reversible method of regulating protein activity, and, as a result, many essential developmental processes."

"Next we tested a mutant form of Hipk that had lost its ability to add phosphates to Yorkie," says Verheyen. "This form of Hipk could no longer prompt Yorkie to trigger cell proliferation or
'/>"/>

Contact: Carol Thorbes
cthorbes@sfu.ca
778-782-3035
Simon Fraser University
Source:Eurekalert

0

GOOD

Page: 1 2

Related medicine news :

1. Protein build-up leads to neurons misfiring
2. Strong communication between brain and muscle requires both having the protein LRP4
3. Regulation by proteins outside cancer cells points to potential new drug target
4. Loss of protein SPDEF allows prostate cancer cells to gain foothold at possible sites of metastasis
5. The key (proteins) to self-renewing skin
6. Researchers discover rare leukemia-causing protein
7. PaleoMeal Organic Whey Protein Formula Improved According to Rockwell Nutrition
8. Moving 3D computer model of key human protein is powerful new tool in fight against cancer
9. Researchers reveal crucial immune fighter role of the STING protein
10. Protein residues kiss, dont tell
11. Overexpression of proteins 14-3-3 related to chemotherapy resistance
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/22/2013)... 2013 Zensah® Compression Apparel released a ... titled "Breast pain while running affects one-third ... could help." According to the article, a British study ... amount suffer from breast pain while running but do ... issue. , Zensah emphasizes the importance for women ...
(Date:5/22/2013)... 2013 Successful Therapy for Parents ... Psychotherapy in the Silver Lake community of Los ... as progression to existing Parents and Couples counseling ... parenting therapy has always been suggested, but now ... now specializes in all aspects of relationships ...
(Date:5/22/2013)... Twenty student-led startup companies at Arizona State ... intensive startup accelerator designed to help them execute their ... local jobs as part of ASU’s Edson Student ... offers approximately 20 student teams up to $20,000 each ... launch their for-profit, more-than-profit or nonprofit ventures. The program, ...
(Date:5/22/2013)... Reporter , , WEDNESDAY, May 22 (HealthDay News) -- Migraines ... suffering, but new research indicates the combination of the ... a smaller brain. , , Already aware that people ... wanted to determine if having both conditions together affected ... 2 percent -- isn,t alarming, study authors said, but ...
(Date:5/22/2013)... May 22, 2013 Hurricane preparation isn’t ... home. That’s why Amica Insurance is reminding ... the upcoming hurricane season. , “An important part of ... Cook, a senior assistant vice president at Amica Insurance. ... before the threat of a storm.” , Flood damage ...
Breaking Medicine News(10 mins):Health News:Zensah® Comments on New York Daily News Article Examining How Better Sports Bra Could Help Women Marathoners 2Health News:Zensah® Comments on New York Daily News Article Examining How Better Sports Bra Could Help Women Marathoners 3Health News:Patricia O’Laughlin Psychotherapy of Los Angeles Now Seeing Adults, Teens and Young Children 2Health News:ASU Announces Edson Student Entrepreneur Initiative’s 2013-2014 Cohort 2Health News:ASU Announces Edson Student Entrepreneur Initiative’s 2013-2014 Cohort 3Health News:ASU Announces Edson Student Entrepreneur Initiative’s 2013-2014 Cohort 4Health News:ASU Announces Edson Student Entrepreneur Initiative’s 2013-2014 Cohort 5Health News:ASU Announces Edson Student Entrepreneur Initiative’s 2013-2014 Cohort 6Health News:ASU Announces Edson Student Entrepreneur Initiative’s 2013-2014 Cohort 7Health News:ASU Announces Edson Student Entrepreneur Initiative’s 2013-2014 Cohort 8Health News:ASU Announces Edson Student Entrepreneur Initiative’s 2013-2014 Cohort 9Health News:Having Both Migraines, Depression May Mean Smaller Brain 2Health News:Having Both Migraines, Depression May Mean Smaller Brain 3Health News:Reviewing Insurance Policies: a Key Part of Hurricane Preparations 2
... LAS VEGAS, Jan. 8 (LVCC S227) ... a new initiative to make,radio more accessible to ... people around the world., At a press ... Vegas,the three organizations announced the global accessible radio ...
... Slumping Economy &, Presidential Election May Mean for Private Equity in ... ... With credit markets in,turmoil, the economy in a seeming slowdown and ... Equity Analyst Outlook,Conference on January 29-30 at the Grand Hyatt in New ...
... most common indication worldwide for pediatric transplantation, biliary atresia ... disease in newborns. Recently, Childrens Hospital of Pittsburgh of ... with biliary atresia face that lead to the need ... children undergoing their first liver transplant are diagnosed with ...
... population growth since the beginning of the XXth Century, ... slave trade and colonization. The regions population in fact ... in 2005. The latest United Nations projections, published in ... billion inhabitants being reached between the present and 2050., ...
... and improves ... customer ... subsidiary of Hays plc., one of the world,s leading specialist,recruitment ... processes and improve customer service., Hays stated that it ...
... MONTVALE, N.J., Jan. 8 Jennifer J. Day, Senior ... announces the,addition of Kenneth A. Sylvia as publisher of ... the healthcare industry who brings to DHM,30 years of ... client bases we serve," Day said. DHM is a ...
Cached Medicine News:Health News:NPR, Harris Corporation and Towson University Launch Global Effort To Make Radio Accessible to Hearing and Sight Impaired 2Health News:NPR, Harris Corporation and Towson University Launch Global Effort To Make Radio Accessible to Hearing and Sight Impaired 3Health News:NPR, Harris Corporation and Towson University Launch Global Effort To Make Radio Accessible to Hearing and Sight Impaired 4Health News:NPR, Harris Corporation and Towson University Launch Global Effort To Make Radio Accessible to Hearing and Sight Impaired 5Health News:Private Equity's Top Execs to Share Advice, Candid Predictions at 2008 Outlook Conference 2Health News:Children's Hospital physicians publish review of transplant issues in patients with biliary atresia 2Health News:Sub-Saharan Africa: the population emergency 2Health News:Sub-Saharan Africa: the population emergency 3Health News:Hays AG Integrates Authentidate(R) Signature Solution for Electronic Invoicing 2Health News:Hays AG Integrates Authentidate(R) Signature Solution for Electronic Invoicing 3Health News:Hays AG Integrates Authentidate(R) Signature Solution for Electronic Invoicing 4
(Date:5/22/2013)... , May 22, 2013 Ranbaxy ... Sankyo Co., Ltd. (hereafter, Daiichi Sankyo), announced on ... in recent years to address past conduct under ... Daiichi Sankyo continues to support ... the conduct of the past which led to ...
(Date:5/22/2013)... REHOVOT, Israel , May 22, 2013 ... a leading developer and provider of microRNA-based molecular diagnostics, ... President and Chief Executive Officer of Rosetta Genomics, will ... Conference taking place from June 3-6, 2013 in New ... Tuesday, June 4 th at 2:00 p.m. Eastern ...
(Date:5/22/2013)... FRANKLIN LAKES, N.J. , May 22, 2013 /PRNewswire/ ... ), a leading global medical technology company, announced today ... This is BD,s fifth Sustainability Report and it continues ... sustainability. "We believe the principles of ... communities and addressing healthcare challenges of societies — are ...
Breaking Medicine Technology:Rosetta Genomics to Present at the Jefferies 2013 Healthcare Conference 2Rosetta Genomics to Present at the Jefferies 2013 Healthcare Conference 3BD Issues 2012 Sustainability Report 2BD Issues 2012 Sustainability Report 3
... efficacy and benefits of early treatment ... with liraglutide versus glimepiride, SAN FRANCISCO, ... of the American Diabetes Association (ADA),demonstrated that once-daily liraglutide when ... in,patients with type 2 diabetes, as compared to glimepiride, a ...
... Calif., June 10 /PRNewswire-FirstCall/ - NeurogesX, Inc.,(Nasdaq: ... and,commercializing novel pain management therapies, announced today the,publication ... candidate, NGX-4010, in the,journal Neurology. The paper, titled, ... Painful HIV,Neuropathy," will appear in the June 10, ...
Cached Medicine Technology:Video: Clinical Study Shows Liraglutide Reduced Blood Sugar, Weight, and Blood Pressure in Patients with Type 2 Diabetes 2Video: Clinical Study Shows Liraglutide Reduced Blood Sugar, Weight, and Blood Pressure in Patients with Type 2 Diabetes 3Video: Clinical Study Shows Liraglutide Reduced Blood Sugar, Weight, and Blood Pressure in Patients with Type 2 Diabetes 4NeurogesX Announces Publication of NGX-4010 Phase 3 HIV-Neuropathy Study Results in Neurology 2NeurogesX Announces Publication of NGX-4010 Phase 3 HIV-Neuropathy Study Results in Neurology 3
... is suspected, every minute counts. ... allows rapid determination of the ... a single whole blood sample. ... within minutes - saving you ...
... Endoscopic cases it is extremely popular to combine ... Light. This combination affords the surgeon optimal ... an uncomfortable pose. The Dual Light System ... System. As such the light can be ...
... offers all the performance of a major surgical ... use in Outpatient Settings, Minor Procedure Rooms, C-Section, ... single lights either side of the OR table ... General OR when combining Flat Screen LCD Monitors ...
A Western Blot Immunassay for the detection of antibodies to primarily anti-myelin associated glycoproteins (anti-MAG) and other glycolipid autoantibodies in human serum....
Medicine Products: