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SEISMIC study issues glum report on cell therapy
Date:4/1/2008

rt is able to pump from the left ventricle with each contractionwas 41.5 percent. At six-month follow-up, the left ventricular ejection fraction was 29.2 percent in the cell-therapy group and 32.9 percent in the control group. Similarly, the enlarged hearts did not shrink as hoped in response to myoblast injection. Instead, at six months, the diameter of the left ventricle was larger in the cell-therapy group than the control group (54.5 mm vs. 39.4 mm, respectively, at the end of each contraction).

However, cell therapy was associated with an improvement in the distance patients were able to walk in six minutes (an additional 60.3 meters in the cell-therapy group vs. an additional 0.4 meters in the control group), but it was not statistically significant. Similarly, in the cell-therapy group, three patients (17.6 percent) experienced some relief of heart-failure symptoms as gauged by a one-step improvement in New York Heart Association (NYHA) functional class; one patient treated with cell injection (5.9 percent) experienced a worsening of NYHA class. By comparison, in the control group, one patient (8.3 percent) experienced an improvement of NYHA class, while five patients (41.7 percent) experienced worsening of heart failure status.

The researchers concluded that injection of cultured skeletal muscle cells in patients with heart failure is feasible and may improve symptoms, but had no detectable effect on heart function or size.

Dr. Serruys will present the results of the "Safety and Effects of Implanted (Autologous) Skeletal Myoblasts (MyoCell) using an Injection Catheter (SEISMIC) study on Tuesday, April 1 at 11:15 a.m. CDT in the Grand Ballroom, S100.


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Contact: Kathy Boyd David
pr@scai.org
717-422-1181
Weber Shandwick Worldwide
Source:Eurekalert

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