Navigation Links
SEARCH study shows 1-year drop in HIV virus levels in rural Ugandan parish after campaign
Date:7/24/2012

Population-wide levels of HIV virus dropped substantially between 2011 and May 2012 in a rural part of southwestern Uganda, the site of two community health campaigns led by doctors at the University of California, San Francisco (UCSF), San Francisco General Hospital and Trauma Center (SFGH) and Makerere University in Kampala, Uganda.

The campaign, which was part of the Sustainable East Africa Research in Community Health (SEARCH) Collaboration, involved free counseling, testing for HIV and other diseases, linkage to care and treatment. This comprehensive approach to addressing HIV/AIDS has been pioneered in San Francisco over the last few years.

Mounting evidence is showing that universal testing and early treatment for HIV can help keep people healthier longer and can reduce the spread of HIV within communities.

In a talk to be presented on Tuesday, July 24, 2012 at the XIX International AIDS Conference in Washington, D.C., members of the UCSF research team will describe early results of their campaign in one resource-limited setting in sub-Saharan Africa, where 60 percent of the world's HIV-infected people reside.

Their effort involved two large community health campaigns in May 2011 and May 2012, in which every resident in a southwestern Ugandan district called Kakyerere Parish (population 6,300) was offered free counseling, testing for HIV and other diseases, and linkage to care. Between the two campaigns, there was a substantial drop in the amount of HIV virus measured in the community.

In 2011, 37 percent of HIV-positive persons had undetectable levels of virus, and by 2012 that number had risen to 55 percent. By contrast, only an estimated 20-30 percent of the people in the United States who are infected have undetectable levels of HIVin part because 1 in 5 Americans living with HIV do not know they are infected.

"Viral loads in the population can be a readout of how we are doing with HIV care across the whole district," said Vivek Jain, MD, MAS, assistant professor of medicine in the UCSF Division of HIV/AIDS at SFGH. "More people in Uganda are accessing therapy, and the therapy they are accessing is achieving success."

What the SEARCH Study Found

In the 2012 study, 4,872 total people (2,271 adults) were tested for HIV over a one-week period, and 210 community adults tested positive for HIV. Those who tested positive were given a separate test to determine the amount of virus in their bloodstreama quantity known as "viral load."

The scientists employed a new method for measuring viral load on-site by taking four drops of blood through a simple finger prick, avoiding the need for standard, more time consuming blood draw procedures that use needles.

After the original health campaign in May 2011, the group conducted a second parish-wide testing campaign in May 2012. Within one year, there had been a substantial reduction in viral loads in the population.

"Every way you look at it, there is less virus in this community," said Diane Havlir, MD chief of the UCSF Division of HIV/AIDS at SFGH and co-director of the SEARCH Collaboration.

There were several possible reasons for the drop in virus, said Jain. To begin with, the community health campaign of 2011 helped identify more people who were infected (including many people who previously did not know they were HIV-positive), and helped link them to medical care. Second, the government of Uganda recently changed the guidelines for offering treatment to allow access to antiretroviral drugs earlier in the course of the HIV disease process, at a higher T cell count threshold.

Finally, people in the community who did not qualify for drugs under the Ugandan government guidelines were nevertheless given access to antiretroviral therapy through a research study also being conducted by the SEARCH group in the district: this study offers therapy to persons at any T cell count, creating an option for residents to access therapy even if their T cell counts are still high.

To build on these encouraging pilot results, said Jain, a large clinical study is needed to rigorously study whether the reduction in virus levels in the population is a direct result of the community health campaign and the expanded access to HIV medicines in the district.


'/>"/>

Contact: Jason Socrates Bardi
jason.bardi@ucsf.edu
415-502-6397
University of California - San Francisco
Source:Eurekalert

Related medicine news :

1. UCLA Brain Injury Research Center gets NCAA funding for research on sports concussions
2. NIH awards $20 million over 5 years to train next generation of global health researchers
3. Researchers develop a new cell and animal model of inflammatory breast cancer
4. Researchers uncover a viable way for colorectal cancer patients to overcome drug resistance
5. Sexually abused boys at risk for more unsafe sex: UBC research
6. Researchers Find Gene Mutations That May Be a Key to Autism
7. LSUHSC research finds HPV-related head & neck cancers rising, highest in middle-aged white men
8. Researchers find evidence of banned antibiotics in poultry products
9. Presidential keynote address and new research highlights from the American Society of Pediatric Otolaryngology meeting
10. Scientific session and new research highlights
11. NJ stroke researchers report advances in spatial neglect research at AAN Conference
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/24/2017)... ... August 24, 2017 , ... Lori ... the development and advances in Desensitization therapy to improve the outcomes of organ ... about his remarkable journey of his 25 years of research in developing therapies ...
(Date:8/24/2017)... ... August 24, 2017 , ... Prime candidates for home ... have a condition that needs further monitoring such as surgery, stroke, heart attack ... stable, such as diabetes, high blood pressure, heart/lung disease, arthritis and stroke. ...
(Date:8/23/2017)... ... 2017 , ... The Arc Mercer, Capitol County’s premier provider of programs and ... community organization for people with special needs. The group, the Special Needs Alliance for ... of New Jersey – but the first in the entire country! , SNAP was ...
(Date:8/23/2017)... ... 2017 , ... Drs. Steven White and Brad Haines are pleased to announce ... of this offer, valued at more than $300 per year, new patients can enjoy ... patients receive a complimentary professional whitening procedure. , Stained or yellowed tooth enamel ...
(Date:8/23/2017)... ... ... Awards have announced the winners of the Best of the IBA Awards in The 2017 ... in the 2017 IBAs were not able to apply for the Best of the IBA ... awards won in the IBAs with a Gold Stevie win counting for three points, a ...
Breaking Medicine News(10 mins):
(Date:8/15/2017)... 2017   Mostyn Law and Gulf Coast Regional Blood ... . The Mostyn Law family has had 3 ... is why Mostyn Law is partnering with Gulf Coast ... its appreciation. Blood supplies are running low. Gulf Coast ... hospital needs in August. That is why the blood center reached ...
(Date:8/15/2017)... , Aug. 15, 2017  AOTI Inc. announced today that ... Therapy Inc., has recently opened a New York City Office in ... usage of its unique Topical Wound Oxygen (TWO 2 ) homecare ... the Accreditation Commission for Health Care (ACHC) under the company,s DMEPOS ... ...
(Date:8/8/2017)... -- BioLineRx Ltd. (NASDAQ/TASE: BLRX), a clinical-stage biopharmaceutical company focused ... for the second quarter ended June 30, 2017. ... and to date: ... Company,s lead project, BL-8040: Announced plans ... novel stem cell mobilization treatment for autologous bone-marrow transplantation ...
Breaking Medicine Technology: