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SCI patients treated with own olfactory ensheathing cells realize neurologic improvement
Date:6/28/2013

ers treated the three patients with transplanted self-donated (autologous) OECs and fibroblasts isolated from olfactory mucosa combined with "intense" neuro-rehabilitation. They found the treatment "safe and feasible" one year after transplantation. There was no evidence of neurological deterioration, neuropathic pain, neuroinfection or tumor growth, wrote the researchers.

"Neurophysiological examinations showed improvement in spinal cord transmission and activity of lower extremity muscles in the surgically treated patients, but not in patients receiving only neuro-rehabilitation," they said.

"We consider that the transplantation of OECs was the main factor contributing to the neurologic improvements in the three transplanted patients," said Dr. Tabakow. "Among the possible mechanisms for improvement is that the transplanted OECs may have mediated some restitution along white matter tracts in these patients."

The researchers added that the modest improvements in neurological function occurred against a "background of intense neuro-rehabilitation, which is probably needed for the improvements, although the experience of the control patients indicated that this in itself is not sufficient."


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Contact: Robert Miranda
cogcomm@aol.com
Cell Transplantation Center of Excellence for Aging and Brain Repair
Source:Eurekalert

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