Navigation Links
SCI patients treated with own olfactory ensheathing cells realize neurologic improvement
Date:6/28/2013

Putnam Valley, NY. (June 28 2013) A team of researchers in Poland who treated three of six paraplegics with spinal cord injury using transplanted olfactory ensheathing cells found that the three treated patients showed neurological improvement and no adverse effects while the three control patients who did not receive transplants saw no improvement.

The study appears as an early e-publication for the journal Cell Transplantation, and is now freely available on-line at http://www.ingentaconnect.com/content/cog/ct/pre-prints/ct0799tabakow.

"Most accepted treatments for spinal cord injury focus on techniques of early neuro-protection aimed at maximum prevention of secondary spinal cord injury and methods to stimulate plasticity in the central nervous system," said study corresponding author Dr. Pawel Tabakow of the Department of Neurosurgery, Wroclaw Medical University in Wroclaw, Poland. "These measures have helped patients with incomplete spinal injury, but results in patients with complete spinal injury remained limited."

According to the researchers, among the various kinds of neurotrophic cells being tested for transplantation to treat spinal cord injury, OECs deserve "special attention" because they are unique in their natural ability to stimulate regrowth of lesioned axons and "evoke long-distance axon regeneration and subsequent recovery of locomotion in paralyzed limbs."

The researchers noted specifically several laboratory studies using animals modeled with spinal cord injury where OECs derived from the olfactory mucosa have been found to stimulate the regrowth of neural nerves when transplanted into laboratory rats with paralyzed limbs. In those studies they found evidence of restored breathing, locomotion and climbing behavior in the animals.

In a phase one of this non-randomized controlled study, the team of researchers treated the three patients with transplanted self-donated (autologous) OECs and fibroblasts isolated from olfactory mucosa combined with "intense" neuro-rehabilitation. They found the treatment "safe and feasible" one year after transplantation. There was no evidence of neurological deterioration, neuropathic pain, neuroinfection or tumor growth, wrote the researchers.

"Neurophysiological examinations showed improvement in spinal cord transmission and activity of lower extremity muscles in the surgically treated patients, but not in patients receiving only neuro-rehabilitation," they said.

"We consider that the transplantation of OECs was the main factor contributing to the neurologic improvements in the three transplanted patients," said Dr. Tabakow. "Among the possible mechanisms for improvement is that the transplanted OECs may have mediated some restitution along white matter tracts in these patients."

The researchers added that the modest improvements in neurological function occurred against a "background of intense neuro-rehabilitation, which is probably needed for the improvements, although the experience of the control patients indicated that this in itself is not sufficient."


'/>"/>

Contact: Robert Miranda
cogcomm@aol.com
Cell Transplantation Center of Excellence for Aging and Brain Repair
Source:Eurekalert

Related medicine news :

1. Acid reflux surgery could help prevent rejection in lung transplant patients
2. Surgeons report melanoma recurs after 10 years in more than 6 percent of patients
3. Lowering costs for higher-cost medicare patients through better outpatient care may be limited
4. Nurse practitioners can boost quality of care for older patients with chronic conditions
5. PET-CT improves care of limited-stage small-cell lung cancer patients
6. hCG Treatments / Diet Doc hCG Diets and Weight Loss Plans Offers New hCG Diet Plans to Help Patients Avoid Unsightly Stretch Marks With Supervised Fast Weight Loss
7. New Dental Plan Makes Dental Care More Affordable for Laura Torrado’s and Dr. Shawn Sadris' Patients
8. RSNA: Exercise Benefits Patients with Type 2 Diabetes
9. Exercise benefits patients with type 2 diabetes
10. Health Insurance for Patients with Mental Illness and Substance Use
11. Jackson, MS Periodontist, Dr. Roger Parkes Brings Gum Disease Patients the FDA-cleared Laser Gum Disease Treatment
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... Apple ... care services, staged a mock evacuation of the facility as part of a disaster ... Fire Department, Echo Hose EMS and Shelton City Emergency Manager, as well as the ...
(Date:10/13/2017)... , ... October 13, 2017 , ... Global Healthcare Management’s ... Alexandria Park in Milford, NJ. This free event, sponsored by Global Healthcare Management’s ... The fun run is geared towards children of all ages; it is a ...
(Date:10/13/2017)... ... October 13, 2017 , ... “The Journey: From the ... danger possible to save lost souls in the Philippines. “The Journey: From the Mountains ... a dedicated teacher of the Bible. She has taught all ages and currently teaches ...
(Date:10/12/2017)... ... October 12, 2017 , ... Planet Fitness, one of the largest and ... plans to open a flagship location in Covington, LA at 401 N. U.S. Highway ... store next to Office Depot in the Holiday Square shopping center. Its location allows ...
(Date:10/12/2017)... ... 2017 , ... Asante, a nationally recognized health system in ... existing home health joint venture through an agreement, effective October 1, 2017, to ... home health company with Asante, delivering clinically integrated care, for the past eight ...
Breaking Medicine News(10 mins):
(Date:10/10/2017)... -- NDS received FDA 510(k) clearance in May 2017 for its highly ... designed for endoscopy environments. An innovative secondary monitor solution, ZeroWire ... support the improvement of patient outcomes, procedural efficiency, and the lowering ... ... ...
(Date:10/4/2017)... 4, 2017  South Korean-based healthcare product Development Company ... "cprCUBE" on Kickstarter. The device will educate the user ... with better efficiency compared to the dated and pricey ... on efficacy of the compression for a more informed ... goal to raise $5,000. ...
(Date:10/2/2017)... 2017  Eli Lilly and Company (NYSE: ... third quarter of 2017 on Tuesday, October 24, 2017. ... day with the investment community and media to further ... call will begin at 9 a.m. Eastern time. Investors, ... webcast of the conference call through a link that ...
Breaking Medicine Technology: