Navigation Links
SCAI Statement on 'A National Study of the Effect of Individual Proton Pump Inhibitors on Cardiovascular Outcomes in Patients Treated with Clopidogrel Following Coronary Stenting: The Clopidogrel Medco Outcomes Study'
Date:5/6/2009

LAS VEGAS, May 6 /PRNewswire/ -- Results of the Clopidogrel Medco Outcomes Study presented today during SCAI's Annual Scientific Sessions found the anti-clotting benefits of clopidogrel (Plavix) may be reduced when taken concurrently with commonly used heartburn medications called proton pump inhibitors (PPIs). In the study, patients taking clopidogrel and a PPI experienced a:

  • 50% increase in the combined risk of hospitalization for heart attack, stroke, unstable angina, or repeat revascularization, including:
    • 70% increase in the risk of heart attack or unstable angina
    • 48% increase in the risk of stroke or stroke-like symptoms
    • 35% increase in the need for a repeat coronary procedure

Dual antiplatelet therapy, which commonly consists of clopidogrel and aspirin, is routinely prescribed to patients following insertion of stents to prevent life-threatening blood clots. PPIs are also frequently prescribed to these patients for brief periods (approximately 30 days) following stent insertion to treat unpleasant but non-life-threatening side effects of clopidogrel such as nausea. In some patients PPIs may also be taken routinely for gastrointestinal conditions like peptic ulcer disease.

The Clopidogrel Medco Outcomes Study is the largest to date to examine the outcomes of patients who are taking clopidogrel and a PPI. However, two smaller, earlier studies came to opposite conclusions concerning adverse effects when patients were taking both medications. The first study, a database analysis, found an increase in cardiac events in patients taking clopidogrel along with a PPI, while the CREDO study found no adverse effect when clopidogrel was taken along with a PPI.

The current study examined outcomes of patients taking common PPI medications including
'/>"/>

SOURCE SCAI
Copyright©2009 PR Newswire.
All rights reserved

2

GOOD

Page: 1 2

Related medicine news :

1. Statement of Eli Lilly and Company on Dr. David Egilman Settlement:
2. Takeda statement on ACTOS meta-analysis published in the Journal of the American Medical Association
3. Takeda Statement on ACTOS(R) (Pioglitazone HCl) Meta-Analysis Published in the Journal of the American Medical Association
4. Statement by Mike Leavitt Secretary of Health and Human Services on the United States-China Bilateral Meetings on Food and Drug Safety
5. Statement by Oscar S. Wyatt, Jr.
6. Statement from Employment Policies Institute on Senator Hillary Clintons Health Care Plan
7. Pelosi Statement on Proposed Entitlement Task Force
8. Statement by Robert Greenstein, Executive Director of the Center on Budget and Policy Priorities, on the New Congressional SCHIP Agreement
9. Statement on House/Senate Agreement on SCHIP Legislation
10. Statement from the Alliance for Quality Nursing Home Care
11. Produce for Better Health Foundation Releases Statement on Study Saying Fruit & Vegetable Consumption Not Strongly Associated With Colon Cancer Risk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/4/2009)...MADISON HEIGHTS, Mich., Dec. 4 The...e of BetterInvesting Magazine today announced A... "Stock to Study" and C.R. Bard, Inc. (NYSE: B...investors, informational and educational use. ,...opportunities involving its flagship drug Botox an...
(Date:12/4/2009)...TON, Dec. 4 While Congr...ol health care costs, Leapfrog,s purchaser members...- delivering the best quality care in the nation w...hirty-four urban, eight children,s and three rural...tals, based on results from The Leapfrog Hospital ...
(Date:12/4/2009)...a risk for some pediatric cancers, particularly Ew...tem, according to a new study published online Dec...titute . , This study was undertaken because the... years and up to 20 years) for pediatric cancer pa...Aflac Cancer Center and Blood Disorders Service, C...
(Date:12/4/2009)..., scientists at Johns Hopkins publishing in the De...ein made by a gene called "Twist" may be the prove...m cells that drive aggressive, metastatic breast c... on recent work suggesting that it is a relatively... drives breast cancer, scientists have surmised th...
(Date:12/4/2009)...ion Americans are recruited annually to participat... Human Research Protection (AHRP), and most will b...earch institutions view payments to volunteers as ...ation for potential risks related to participating...olunteers have a very different view of clinical t...
Breaking Medicine News(10 mins):Health News:BetterInvesting Magazine Releases February Stock to Study and Undervalued Stock Choicesfor Investors' Informational and Educational Use 2Health News:The Leapfrog Group Releases Its 2009 Top Hospitals List 2Health News:The Leapfrog Group Releases Its 2009 Top Hospitals List 3Health News:Potential new 'twist' in breast cancer detection 2Health News:Potential new 'twist' in breast cancer detection 3Health News:Human guinea pigs wary of high-paying medical trials 2
...ed a bird flu alert in all states as the season of.../ "We have given clear instruction to all ou...e till February next year," said Upma Chawdhry, jo...ary this year have been instructed to send their m...
...id H. Nordbo, of the Norwegian Institute of Public... people// suffering anorexia nervosa, a form of ea...al disease attribute a great deal of importance to...icance the illness holds in the patients’ lives, m...
...s of erotic pictures and sensuous pleasures besee...in rapt attention// and causes a man to file away ... his mind says scientists who conducted a study o...e nude or sexually arousing picture is briefly sho...
...na is the world’s tallest man alive. He is 7 feet,...ebrated across the globe on November 9th. Xi will ...ns. His record will be published in the Guinne.... Xi is a herdsman by profession and was bor...
... prevent old age blindness is being developed, acc... that is being designed to combat the wet type of ...tential to prevent blindness in several people, wh...d vision loss in 90% of the patients studied. A re...
...as been one of the major causes of death in Scotla... the next two decades// according to the Chief Med...Harry Burns, "In the 1960s, one in 100 men died of...e disease becomes rare." He said that lung canc...
Other Medicine News:Health News:India sounds bird flu alert as migration season begins 2Health News:Naked truths and Basic Instincts 2Health News:Eradication of Lung Cancer in 20 years 2Health News:Eradication of Lung Cancer in 20 years 3
(Date:12/4/2009)..., Dec. 4 PharmAthene, In...ping medical countermeasures against biological an...ny is presenting results of a study demonstrating ...on anthrax model in the New Zealand White (NZW) ra... session at the HHS Public Health Emergency Medica...
(Date:12/4/2009)..., N.Y., Dec. 4 Bayer Diabetes Care...Bayer,s "Express Your Simple Win Creativity Contes...e winning video entries submitted by children with... is an in-person meeting today with Nick. ,, ...re: Caleb, age 6, from Danbury, CT, who dreams of ...
(Date:12/3/2009)...ec. 3 Guidepoint Global, LLC , a ... launch of their Sleep Apnea Tracker, a monthly lo... trends and market share in the worldwide Sleep Ap...s actual patient usage for 87 different Sleep Apne...fferent equipment providers going back to January ...
Breaking Medicine Technology:PharmAthene Presents Animal Model Data for Valortim(R) at the 2009 BARDA Industry Conference / PHEMCE Stakeholders Workshop 2PharmAthene Presents Animal Model Data for Valortim(R) at the 2009 BARDA Industry Conference / PHEMCE Stakeholders Workshop 3PharmAthene Presents Animal Model Data for Valortim(R) at the 2009 BARDA Industry Conference / PHEMCE Stakeholders Workshop 4PharmAthene Presents Animal Model Data for Valortim(R) at the 2009 BARDA Industry Conference / PHEMCE Stakeholders Workshop 5PharmAthene Presents Animal Model Data for Valortim(R) at the 2009 BARDA Industry Conference / PHEMCE Stakeholders Workshop 6Bayer 'Express Your Simple Win Creativity Contest' Grand Prize Winners Announced 2Bayer 'Express Your Simple Win Creativity Contest' Grand Prize Winners Announced 3Leading Primary Research Firm Guidepoint Global Announces Launch of Sleep Apnea Tracker 2Brown professor continues debate over recovered memory 50995 1Brown professor continues debate over recovered memory 50995 2Dietary supplements manufacturers gain new tool to help ensure quality products 9150 1Dietary supplements manufacturers gain new tool to help ensure quality products 9150 2MagnaCare Answers Need for New Prescription Drug Program 50993 1MagnaCare Answers Need for New Prescription Drug Program 50993 2
...mark, October 31 , - DoctorConsult in Germany Mar...hat Improve Clinician Decision Making and Health C...ng of healthcare workflow and more than a,century ...ier is increasing,its efforts to provide interacti...t (CDS) tools to new markets in Europe. With the l...
... Four novel genes that may,significantly increase...zheimer,s have been identified by researchers at M...School, as reported in the November 7th issue,of A...art of a larger,"Alzheimer,s Genome Project" (AGP)...set of Alzheimer,s disease genetic risk factors, m...
Other Medicine Technology:Elsevier is Expanding eClinical Solutions in Europe 2Elsevier is Expanding eClinical Solutions in Europe 3Breakthrough Mapping of Alzheimer's Genome Helps ID Four New Suspect Genes 2Breakthrough Mapping of Alzheimer's Genome Helps ID Four New Suspect Genes 3
Specimen Mounts 1/2" head
...tome 900R is a modular peltier refrigeration syste...utilizes the Deluxe bath system as standard which ...epeatable specimen orientation. The unit will chi...entigrade to ambient temperature. It will maintai...
...vides a convenient reservoir of cooling water for ...n extended period of time or in a location which h...ide of the thermoelectric heat pump. The reservoi...uate to run the 900R for up to eight hours. Water...
Arrayer Punch Set, 1.5 mm, for ATA100, Recipient & Donor, Needles, Styli, & Collets
Medicine Products: