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SBRT eliminates tumors with promising survival for early-stage inoperable lung cancer patients
Date:3/16/2010

percent and 55.8 percent, respectively. Median disease-free survival and overall survival for all patients were 34.4 months and 48.1 months, respectively. Seven patients (12.7 percent) and two patients (3.6 percent) were reported to experience protocol-specified treatment-related grade 3 and 4 adverse events, respectively. No grade 5 treatment-related adverse events were reported. Higher grades indicate greater severity of adverse event, with grade 5 indicating death.

"While this is a phase II study involving a relatively small patient sample, these results suggest that this technique could greatly improve survival rates for patients with inoperable non-small cell lung cancer. For this group of patients there simply has not been significant advance in survival rates in some time. These results certainly dictate that further study of SBRT is warranted. We are optimistic that the technique holds promise for these patients," said Timmerman

According to Walter J. Curran, Jr., MD, the RTOG Group Chair, and the Executive Director of the Winship Cancer Institute of Emory University, "RTOG 0236 demonstrated that technologically intensive treatments like SBRT can be performed in the cooperative group setting so long as effective quality control measures are in place to assure patient safety. As the preeminent group conducting multi-institutional clinical trials of novel radiation therapy techniques, RTOG is building on these results to improve patient outcomes and quality of life with trials designed to address the rather high rate of disseminated failure observed after treatment, determine a safe and effective dose for central lung tumors, and refine the dose of SBRT for peripheral tumors."


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Contact: Shawn Farley
sfarley@acr-arrs.org
703-648-8936
American College of Radiology / American Roentgen Ray Society
Source:Eurekalert

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