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SBRT eliminates tumors with promising survival for early-stage inoperable lung cancer patients
Date:3/16/2010

ption that produces better outcomes and may represent an updated, and ultimately more successful, approach to the treatment of patients with early stage inoperable lung cancer," said Timmerman.

This is the first North American multicenter, cooperative group study to test SBRT in treating medically inoperable patients with early stage non-small cell lung cancer. Dr. Timmerman and RTOG member investigators enrolled 59 patients to this phase II study that included patients 18 years or older with biopsy-proven peripheral T1-T2N0M0 non-small cell tumors (measuring less than 5 cm. in diameter) and medical conditions that would not allow surgical treatment. Radiation treatment lasted between 1.5 and 2 weeks. The study opened May 2004 and closed October 2006, with data analyzed through August 2009. The final study population included 55 evaluable patients (44 with T1 tumors and 11 patients with T2 tumors), with a median (midpoint) follow-up of 33.4 months.

The primary outcome measured for the study was 2-year actuarial primary tumor control; secondary end points were disease-free survival (i.e., primary tumor, involved lobe, regional, and disseminated recurrence [the reappearance or return of a cancer in multiple areas of the body]), treatment-related toxicity, and overall survival.

Of all the patients in the study, only one experienced a documented tumor recurrence or progression at the primary site. The 3-year primary tumor control rate was 97.6 percent. Three patients had recurrence within the involved lobe; the 3-year primary tumor and involved lobe (local) control rate was 90.6 percent. Combining local and regional failures, the 3-year local-regional control rate was 87.2 percent. Disseminated recurrence as some component of recurrence was reported in 11 patients. The 3-year rate of disseminated failure was 22.1 percent with 8 such failures occurring prior to 24 months.

Disease-free survival and overall survival at 3 years were 48.3
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Contact: Shawn Farley
sfarley@acr-arrs.org
703-648-8936
American College of Radiology / American Roentgen Ray Society
Source:Eurekalert

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