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SBRT eliminates tumors with promising survival for early-stage inoperable lung cancer patients
Date:3/16/2010

Philadelphia Highly-focused stereotactic body radiation therapy (SBRT) can eliminate the targeted tumor while avoiding treatment-related illness and may ultimately improve survival for patients with inoperable non-small cell lung cancer, according to early findings of a Radiation Therapy Oncology Group study published in the March 17 cancer-themed issue of the Journal of the American Medical Association. Stereotactic body radiation therapy (SBRT) is a noninvasive cancer treatment in which numerous small, highly focused, and accurate radiation beams are used to deliver potent doses in 1 to 5 treatments to tumor targets.

"The primary finding and perhaps most exciting aspect to this prospective study was the high rate of primary tumor control (97.6 percent at 3 years). Primary tumor control is an essential requirement for the cure of lung cancer. Stereotactic body radiation therapy as delivered in RTOG 0236 provided more than double the rate of primary tumor control previous reported for conventional radiotherapy suggesting that this technique could provide a significant step forward in the battle against this type of lung cancer," said Robert Timmerman, MD, of the University of Texas Southwestern Medical Center, Dallas, principal investigator on the RTOG study.

Currently, patients with inoperable early stage lung cancer are generally offered conventional radiation treatment (most commonly given during 20-30 outpatient treatments) or observed without specific cancer therapy. However, study authors indicate that neither of these approaches achieves ideal outcomes.

"Conventional radiotherapy fails to provide long-term control of the primary lung tumor in approximately two-thirds (60 percent to 70 percent) of patients. Most ultimately die specifically from progressive lung cancer with observation, and 2-year survival is less than 40 percent with either approach. Our study suggests that stereotactic body radiation therapy is a new o
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Contact: Shawn Farley
sfarley@acr-arrs.org
703-648-8936
American College of Radiology / American Roentgen Ray Society
Source:Eurekalert

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