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Ruxolinitib better at reducing myelofibrosis symptoms, study shows
Date:12/12/2011

re effective at reducing symptoms than the best available chemotherapies -- specifically, the off-label drugs doctors have been offering.

"The studies confirmed the drug is very effective. As a representative of a particular class of molecular inhibitors called JAK2 inhibitors, which are now being widely studied, ruxolinitib suggests this category will continue to be promising for myelofibrosis," Dr. Mesa says. Most surprising for researchers, however, was the ultimate comparison between the two clinical trials.

"When we looked at the control arms of the two studies we found that the best available chemotherapies we've been using up to this time are no more effective than a placebo," Dr. Mesa says. The comparison provided a wake-up call, he adds. "This was a unique piece of information we hadn't had in the past, and it offers further incentive and pressure to find better therapies for patients."


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Contact: Joe Dangor
newsbureau@mayo.edu
507-284-5005
Mayo Clinic
Source:Eurekalert

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