Navigation Links
Rutgers researchers show how the brain can protect against cancer
Date:6/9/2008

New Brunswick, NJ--Scientists have been aware for many years that if cancer patients are not able to deal with the stress associated with being sick, the cancer will progress faster than in calmer patients. To counteract this phenomenon, physicians encourage treatments that help cancer patients handle their stress. Scientists theorized that the stress relief may have come as a result of increased beta-endorphin peptide (BEP), the "feel good" hormones in the brain that are released during exercise, a good conversation, and many other aspects of life that give humans pleasure.

Researchers at Rutgers hypothesized that BEP producing neurons do not just make us feel good, but also play roles in regulating the stress response and immune functions to control tumor growth and progression. In a paper published today in the Proceedings of the National Academy of Science, Dr. Dipak K. Sarkar and his colleagues demonstrate the physical mechanisms that support their hypothesis.

"Our findings show promise for future therapeutic treatments for bolstering the immune function," said Sarkar, professor of animal sciences and director of the Endocrinology Program at the Rutgers School of Environmental and Biological Sciences, and principal investigator of the research project.

Previous research has shown that too few, or inactive, BEP neurons are associated with various diseases. For example, low numbers of BEP neurons have been identified in the brains of patients with depression and schizophrenia. Neurons that produce too little BEP are found in many obese patients. In both these cases the patients also had higher levels of infection and more incidence of cancer.

To test their hypothesis about the role of BEP in controling tumor growth and progression, the Rutgers scientists took neural stem cells, transformed them into BEP neurons by treating them with particular chemicals, and then transplanted them into brains of live rats. The authors studied tumor growth in the rats that had been given carcinogens to induce prostate tumors. The authors noted that the BEP neurons boosted the immune system by increasing the activity of particular immune cell types and decreasing inflammation.

The neurons also protected the rats against prostate cancer 90 percent of the time. The researchers discovered that the "natural killer," or NK cells that typically attack cancer cells in the body, are activated by the inserted BEP neurons. The NK cells reduced inflammation around the cancer cells, which slowed down caner cell growth and killed many of these cells.

"We are optimistic that this research can be applied to human medicine," said Sarkar. "Instead of transplanting cells, we will investigate whether we can increase BEP using a chemical approach."


'/>"/>

Contact: Michele Hujber
hujber@aesop.rutgers.edu
732-932-7000
Rutgers University
Source:Eurekalert

Related medicine news :

1. The Healthcare Foundation of NJ awards grant to Rutgers College of Nursings Rachel Jones
2. 2 Rutgers College of Nursing Ph.D students to receive FNSNA Fellowships
3. Rutgers College of Nursings Linda Flynn to receive N.J. Governors Nursing Merit Award
4. Rutgers research partner Stemcyte, Inc., expands to New Jersey
5. The Zonta Club of Essex County honors Rutgers College of Nursings Rachel Jones
6. Julia Quinlan to present awards at a conference hosted by Rutgers College of Nursing
7. Rutgers researchers unlock mysteries of vitamin A metabolism during embryonic development
8. NJSNA honors Rutgers College of Nursings Linda Flynn for excellence in research
9. Rutgers center sparks liquid bandage, a new frontline wound treatment
10. Rutgers College of Nursing faculty member Rachel Jones awarded Rutgers-Newark Provost Award
11. Rutgers College of Nursing emerita professor Beverly Whipple receives FSSS book award
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/12/2017)... WILMINGTON, Del. (PRWEB) , ... October 12, 2017 ... ... technology and advisory services for healthcare compliance program management, will showcase a range ... and National Association for Assisted Living (NCAL) Convention and Expo to be held ...
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... IsoComforter, Inc. ... products, announced today the introduction of an innovative new design of the shoulder pad. ... so you get maximum comfort while controlling your pain while using cold therapy. By ...
(Date:10/12/2017)... ... 2017 , ... Dr. Parsa Mohebi, the Los Angeles based ... the newly revamped Cosmetic Town journal section, featuring articles written by ... as Follicular Unit Extraction (FUE). , Dr. Mohebi says “I enjoy ...
(Date:10/12/2017)... ... October 12, 2017 , ... Women-owned and ... 2017 Best and Brightest in Wellness® by Best and Brightest. OnSite Wellness will ... Friday, Oct. 20 from 7:30 a.m. to 2 p.m. at the Henry Autograph ...
(Date:10/12/2017)... , ... October 12, 2017 , ... ... at the University of California Berkeley, and other leading institutions in announcing the ... power of institutions to change the way animals are raised for food. , ...
Breaking Medicine News(10 mins):
(Date:10/10/2017)... , Oct. 10, 2017   West Pharmaceutical ... innovative solutions for injectable drug administration, today shared the ... ID Adapter for improving the intradermal administration of polio ... Skin Vaccination Summit in May 2017 by Dr. ... Polio Department, World Health Organization (WHO), and recently published ...
(Date:10/4/2017)... Centers for Disease Control and Prevention (CDC), influenza vaccination should take ... communities across Massachusetts , Connecticut , ... through the end of the month. *Some exclusions apply ... ... by the end of October, according to the Centers for Disease Control ...
(Date:10/2/2017)...  AllianceRx Walgreens Prime, the combined central specialty pharmacy ... benefit manager Prime Therapeutics LLC (Prime), today officially began ... unveiling of new signage at its headquarters in ... a few other company-owned facilities across the country. This ... of whom will begin to see the AllianceRx Walgreens ...
Breaking Medicine Technology: