Navigation Links
Rutgers researchers discover how HIV resists AZT
Date:9/19/2010

NEW BRUNSWICK, N.J. Rutgers researchers have discovered how HIV-1, the virus that causes AIDS, resists AZT, a drug widely used to treat AIDS.

The scientists, who report their findings in Nature Structural & Molecular Biology, believe their discovery helps researchers understand how important anti-AIDS treatments can fail and could help AIDS researchers develop more effective treatment for the disease.

"What we've found is the detailed way in which the mutations act to promote the resistance," said author Eddy Arnold, Board of Governors Professor of Chemistry and Chemical Biology, and a resident faculty member of the Center for Advanced Biotechnology and Medicine. "Instead of blocking the actions of AZT, the virus actually removes it, and it does so by using ATP, one of the most common cellular molecules. This is an outstanding example of how sneaky HIV can be in thwarting the efficacy of therapeutic drugs."

AZT was once the only treatment for AIDS, and it remains an important treatment, particularly in preventing the transmission of the virus from infected mothers to their unborn children.

Researchers knew almost from the beginning that the virus developed resistance to AZT, and that this resistance had to do with mutations, but the way the mutations worked to resist the drug was mysterious.

AZT works by inhibiting an enzyme, reverse transcriptase, which HIV needs to produce DNA from RNA, and thus replicate itself. About 10 years ago, biochemical studies in several laboratories established that AZT-resistant HIV-1 reverse transcriptase uses adenosine triphosphate, or ATP, which moves energy around inside the cell, to remove the AZT. Arnold and his co-authors have used X-ray crystallography to describe in atomic detail how the AZT-resistance mutations allow reverse transcriptase to recruit ATP to remove the AZT.


'/>"/>

Contact: Ken Branson
kbranson@ur.rutgers.edu
908-797-2590
Rutgers University
Source:Eurekalert

Page: 1

Related medicine news :

1. Reality TV, cosmetic surgey linked, says Rutgers-Camden researcher
2. Rutgers and the Prostate Net host prostate cancer symposium, May 15
3. Dr. Carl Djerassi, inventor of The Pill, to receive honorary doctorate from Rutgers University
4. Rutgers Stem Cell Research Center derives new cell lines and trains stem cell scientists
5. Rutgers historian puts 50th anniversary of the pill into cultural medicine cabinet
6. Rutgers University Offers Fundamentals of Finance and Accounting Workshop at Mount Laurel, New Jersey Location Aimed at Non-Financial Managers
7. Snowmen Notwithstanding, It's Time To Register For Rutgers' Summer Session
8. Researchers at SUNY Downstate find drug combination may treat traumatic brain injury
9. Do the math, say UCLA researchers
10. MIT researchers discover an unexpected twist in cancer metabolism
11. OHSU researchers able to determine brain maturity through analyzing MRI scans
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/4/2015)... (PRWEB) , ... August 04, 2015 , ... Many men ... on the subject, Renew Man™ is standing up as a voice of authority for ... of the healthy aging industry with special experience and expertise in the safe and ...
(Date:8/4/2015)... ... ... 24/7 Care At Home , a provider of comprehensive home health ... the U.S. Department of Veteran’s Affairs (VA) has awarded its agency a rating of ... the path to meeting the aspirational goals the VA promotes each year. , ...
(Date:8/4/2015)... Ohio (PRWEB) , ... August 04, 2015 , ... ... have up-to-date immunizations, especially those entering kindergarten. All required immunizations are covered for ... rules, which means that children who aren’t caught up with their immunizations may ...
(Date:8/4/2015)... , ... August 04, 2015 , ... ... firms and government entities, today announced that John Munro, a 15-year veteran of ... President of Managed Services Operations. , “I am thrilled to join Discovia at ...
(Date:8/4/2015)... ... August 04, 2015 , ... ... announced that Bruce McCalley joins its executive leadership team as Senior Vice President ... success at technology companies and expanding global markets with a special emphasis on ...
Breaking Medicine News(10 mins):Health News:New Video from Renew Man™ Raises Awareness of the Right Way to Correct Low Testosterone 2Health News:New Video from Renew Man™ Raises Awareness of the Right Way to Correct Low Testosterone 3Health News:24/7 Care At Home Receives Two Stars from the VA 2Health News:24/7 Care At Home Receives Two Stars from the VA 3Health News:Buckeye Health Plan Reminds Parents to Keep Immunizations In Mind As School Year Kicks Off 2Health News:John Munro Joins eDiscovery Leader Discovia as Vice President of Managed Services Operations 2Health News:John Munro Joins eDiscovery Leader Discovia as Vice President of Managed Services Operations 3Health News:SanusEO Hires Healthcare Technology Executive Bruce McCalley As Senior Vice President of Sales & Marketing 2Health News:SanusEO Hires Healthcare Technology Executive Bruce McCalley As Senior Vice President of Sales & Marketing 3
... conducted by the anthropologists, from the University of Connecticut, University ... , ,They said that Neanderthals were very good in hunting ... modern humans. ,But the early modern humans ... due to the competition they received from the early modern ...
... by scientists belonging to the Northwestern University targeted at ... //The gene therapy, described in the January online issue ... Bohn and her laboratory group at Northwestern University Feinberg ... Medical Research Council Professor and director of the neurobiology ...
... on the rise and is rapidly becoming the number one cancer ... seriousness of the situation is apparent after going through recent data ... ,The rise is being documented mainly in the metros, but it ... unnoticed. It is reported that one in 22 women in India ...
... more than a couple of seconds to decide whether the ... findings. The decision is often taken in less than a ... impossible to really see anything in less than 500 milliseconds,’ ... has published the research in the journal Behavior and Information ...
... improvements made in diagnoses and treatment of the fatal ... a cure rate of 90%, according to researchers belonging ... ,The progressive improvement in the cure rate since ... reflects in large part the more effective use of ...
... to medical science, doctors under the leadership of Dr Hasan ... would perform surgery on patients while they// are in a ... out from their bodies while the surgery is being performed ... is complete. ,The return of blood would be ...
Cached Medicine News:Health News:Acute Lymphoblastic Leukemia May Attain a 90% Cure Rate 2
(Date:8/4/2015)... , Aug. 4, 2015 BioElectronics Corporation ... ActiPatch® Musculoskeletal Pain Therapy medical devices, announced today ... its ActiPatch 7-day trial device has been published ... Pain Management http://www.futuremedicine.com/doi/full/10.2217/PMT.15.35 .  More than ... and submitted an assessment.  Chronic ...
(Date:8/4/2015)... KNOXVILLE, Tenn., Aug. 4, 2015 Second ... million; 30.1% over second quarter of 2014 , Net ... $28.9 million; $51.2 million after adjustments , Diluted net ... , Adjusted EBITDA increased 15.2% to $99.4 million ... increased to a range of 24.0% to 26.0%; Adjusted EBITDA ...
(Date:8/4/2015)... Minn., Aug. 4, 2015 ANI Pharmaceuticals, Inc. ... for the three and six months ended June 30, ... Company will host its earnings conference call this morning, ... other interested parties can join the call by dialing ... Year-to-Date Highlights Include: , Year-to-date net revenues of ...
Breaking Medicine Technology:BioElectronics' Landmark 5,000+ Chronic Pain Patient Study Published in Pain Management Medical Journal 2Team Health Holdings, Inc. Announces Second Quarter 2015 Financial Results 2Team Health Holdings, Inc. Announces Second Quarter 2015 Financial Results 3Team Health Holdings, Inc. Announces Second Quarter 2015 Financial Results 4Team Health Holdings, Inc. Announces Second Quarter 2015 Financial Results 5Team Health Holdings, Inc. Announces Second Quarter 2015 Financial Results 6Team Health Holdings, Inc. Announces Second Quarter 2015 Financial Results 7Team Health Holdings, Inc. Announces Second Quarter 2015 Financial Results 8Team Health Holdings, Inc. Announces Second Quarter 2015 Financial Results 9Team Health Holdings, Inc. Announces Second Quarter 2015 Financial Results 10Team Health Holdings, Inc. Announces Second Quarter 2015 Financial Results 11Team Health Holdings, Inc. Announces Second Quarter 2015 Financial Results 12Team Health Holdings, Inc. Announces Second Quarter 2015 Financial Results 13Team Health Holdings, Inc. Announces Second Quarter 2015 Financial Results 14Team Health Holdings, Inc. Announces Second Quarter 2015 Financial Results 15Team Health Holdings, Inc. Announces Second Quarter 2015 Financial Results 16Team Health Holdings, Inc. Announces Second Quarter 2015 Financial Results 17Team Health Holdings, Inc. Announces Second Quarter 2015 Financial Results 18Team Health Holdings, Inc. Announces Second Quarter 2015 Financial Results 19Team Health Holdings, Inc. Announces Second Quarter 2015 Financial Results 20Team Health Holdings, Inc. Announces Second Quarter 2015 Financial Results 21Team Health Holdings, Inc. Announces Second Quarter 2015 Financial Results 22Team Health Holdings, Inc. Announces Second Quarter 2015 Financial Results 23Team Health Holdings, Inc. Announces Second Quarter 2015 Financial Results 24Team Health Holdings, Inc. Announces Second Quarter 2015 Financial Results 25Team Health Holdings, Inc. Announces Second Quarter 2015 Financial Results 26Team Health Holdings, Inc. Announces Second Quarter 2015 Financial Results 27Team Health Holdings, Inc. Announces Second Quarter 2015 Financial Results 28Team Health Holdings, Inc. Announces Second Quarter 2015 Financial Results 29Team Health Holdings, Inc. Announces Second Quarter 2015 Financial Results 30Team Health Holdings, Inc. Announces Second Quarter 2015 Financial Results 31Team Health Holdings, Inc. Announces Second Quarter 2015 Financial Results 32Team Health Holdings, Inc. Announces Second Quarter 2015 Financial Results 33ANI Pharmaceuticals Reports Second Quarter and Year-To-Date 2015 Results and Highlights 2ANI Pharmaceuticals Reports Second Quarter and Year-To-Date 2015 Results and Highlights 3
... International Holdings, Inc. (NYSE Amex: BONE ... bone graft material and antimicrobial coatings for medical ... three-year agreement with Novation, a leading health care ... provides Bacterin,s full biologic portfolio, including OsteoSponge®, OsteoSelect® ...
... Fla., May 8, 2012 Grappling with economic uncertainty, ... industry is on the cusp of major changes, said ... opening session of the 2012 GHX Healthcare Supply Chain ... GPOs and distributors gathered this week in Orlando for ...
Cached Medicine Technology:Bacterin International Signs Its Third National GPO Contract with Novation 2Bacterin International Signs Its Third National GPO Contract with Novation 3Bacterin International Signs Its Third National GPO Contract with Novation 4GHX Reveals Roadmap to Stronger Healthcare Community at GHX Healthcare Supply Chain Summit 2GHX Reveals Roadmap to Stronger Healthcare Community at GHX Healthcare Supply Chain Summit 3
... Sensor is the first sensor designed specifically ... sensor is the first and only sensor ... and children. Cyanotic infants and children ... and accurate pulse oximetry, and Masimo's research ...
ELISA kit for Varicella-zoster IgG detection....
... Virus (VZV) IgG Enzyme-Linked Immunosorbent Assay (ELISA) ... determination of IgG antibody to VZV in ... be used for the determination of immune ... be used to demonstrate seroconversion or a ...
Inquire...
Medicine Products: