Navigation Links
Rutgers researchers discover how HIV resists AZT
Date:9/19/2010

NEW BRUNSWICK, N.J. Rutgers researchers have discovered how HIV-1, the virus that causes AIDS, resists AZT, a drug widely used to treat AIDS.

The scientists, who report their findings in Nature Structural & Molecular Biology, believe their discovery helps researchers understand how important anti-AIDS treatments can fail and could help AIDS researchers develop more effective treatment for the disease.

"What we've found is the detailed way in which the mutations act to promote the resistance," said author Eddy Arnold, Board of Governors Professor of Chemistry and Chemical Biology, and a resident faculty member of the Center for Advanced Biotechnology and Medicine. "Instead of blocking the actions of AZT, the virus actually removes it, and it does so by using ATP, one of the most common cellular molecules. This is an outstanding example of how sneaky HIV can be in thwarting the efficacy of therapeutic drugs."

AZT was once the only treatment for AIDS, and it remains an important treatment, particularly in preventing the transmission of the virus from infected mothers to their unborn children.

Researchers knew almost from the beginning that the virus developed resistance to AZT, and that this resistance had to do with mutations, but the way the mutations worked to resist the drug was mysterious.

AZT works by inhibiting an enzyme, reverse transcriptase, which HIV needs to produce DNA from RNA, and thus replicate itself. About 10 years ago, biochemical studies in several laboratories established that AZT-resistant HIV-1 reverse transcriptase uses adenosine triphosphate, or ATP, which moves energy around inside the cell, to remove the AZT. Arnold and his co-authors have used X-ray crystallography to describe in atomic detail how the AZT-resistance mutations allow reverse transcriptase to recruit ATP to remove the AZT.


'/>"/>

Contact: Ken Branson
kbranson@ur.rutgers.edu
908-797-2590
Rutgers University
Source:Eurekalert

Page: 1

Related medicine news :

1. Reality TV, cosmetic surgey linked, says Rutgers-Camden researcher
2. Rutgers and the Prostate Net host prostate cancer symposium, May 15
3. Dr. Carl Djerassi, inventor of The Pill, to receive honorary doctorate from Rutgers University
4. Rutgers Stem Cell Research Center derives new cell lines and trains stem cell scientists
5. Rutgers historian puts 50th anniversary of the pill into cultural medicine cabinet
6. Rutgers University Offers Fundamentals of Finance and Accounting Workshop at Mount Laurel, New Jersey Location Aimed at Non-Financial Managers
7. Snowmen Notwithstanding, It's Time To Register For Rutgers' Summer Session
8. Researchers at SUNY Downstate find drug combination may treat traumatic brain injury
9. Do the math, say UCLA researchers
10. MIT researchers discover an unexpected twist in cancer metabolism
11. OHSU researchers able to determine brain maturity through analyzing MRI scans
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/22/2017)... ... May 22, 2017 , ... Patients who avoid necessary dental ... sedation dentistry in Mt. Kisco, NY from Advanced Endodontics of Westchester. This highly-trained team ... of treatments. One or more sedation methods may be recommended based on the severity ...
(Date:5/22/2017)... (PRWEB) , ... May 22, 2017 , ... “Homeostasis: The ... experience learning to live with Bipolar 1. Donald Rodriguez takes readers on a rollercoaster ... Alaska in the dead of winter and to a dark place where Donald considers ...
(Date:5/22/2017)... IL (PRWEB) , ... May 22, 2017 , ... ... is part of a larger group investing in InsightRX, an early stage company ... patient’s underlying biological and pharmacological characteristics. Greatpoint Ventures Innovation Fund acted ...
(Date:5/21/2017)... ... May 20, 2017 , ... Pixel Film Studios presents ... use in Final Cut Pro X. The business-oriented elements and dignified animations are ... ProParagraph Corporate will deliver a professional and distinguished look to any multi-line text ...
(Date:5/21/2017)... ... May 21, 2017 , ... For more than 20 ... a wide range of knives and swords, from functional to fantasy. United Cutlery has ... with sleek, modern designs that defy tradition. , Offering a range of weapons and ...
Breaking Medicine News(10 mins):
(Date:5/10/2017)... BURNIE, Md. , May 10, 2017 ... retention solutions for the clinical research industry, is proud ... www.CSSiEnroll.com . The new website features both enriched ... overall user experience and enhances the company,s already well-established ... the industry. "After many months of ...
(Date:5/9/2017)... , May 9, 2017  Demonstrating its commitment ... of directors for the Pharmaceutical Research and Manufacturers ... membership. Biopharmaceutical companies will now have to meet ... to be eligible to join PhRMA. ... board is sending a clear message that being ...
(Date:5/9/2017)... , May 9, 2017  Semler Scientific, ... provides technology solutions to improve the clinical effectiveness ... results for the first quarter ended March 31, ... products enable our customers to identify when preventive ... intervene before events like heart attacks or strokes ...
Breaking Medicine Technology: