Navigation Links
Rutgers researchers discover how HIV resists AZT
Date:9/19/2010

NEW BRUNSWICK, N.J. Rutgers researchers have discovered how HIV-1, the virus that causes AIDS, resists AZT, a drug widely used to treat AIDS.

The scientists, who report their findings in Nature Structural & Molecular Biology, believe their discovery helps researchers understand how important anti-AIDS treatments can fail and could help AIDS researchers develop more effective treatment for the disease.

"What we've found is the detailed way in which the mutations act to promote the resistance," said author Eddy Arnold, Board of Governors Professor of Chemistry and Chemical Biology, and a resident faculty member of the Center for Advanced Biotechnology and Medicine. "Instead of blocking the actions of AZT, the virus actually removes it, and it does so by using ATP, one of the most common cellular molecules. This is an outstanding example of how sneaky HIV can be in thwarting the efficacy of therapeutic drugs."

AZT was once the only treatment for AIDS, and it remains an important treatment, particularly in preventing the transmission of the virus from infected mothers to their unborn children.

Researchers knew almost from the beginning that the virus developed resistance to AZT, and that this resistance had to do with mutations, but the way the mutations worked to resist the drug was mysterious.

AZT works by inhibiting an enzyme, reverse transcriptase, which HIV needs to produce DNA from RNA, and thus replicate itself. About 10 years ago, biochemical studies in several laboratories established that AZT-resistant HIV-1 reverse transcriptase uses adenosine triphosphate, or ATP, which moves energy around inside the cell, to remove the AZT. Arnold and his co-authors have used X-ray crystallography to describe in atomic detail how the AZT-resistance mutations allow reverse transcriptase to recruit ATP to remove the AZT.


'/>"/>

Contact: Ken Branson
kbranson@ur.rutgers.edu
908-797-2590
Rutgers University
Source:Eurekalert

Page: 1

Related medicine news :

1. Reality TV, cosmetic surgey linked, says Rutgers-Camden researcher
2. Rutgers and the Prostate Net host prostate cancer symposium, May 15
3. Dr. Carl Djerassi, inventor of The Pill, to receive honorary doctorate from Rutgers University
4. Rutgers Stem Cell Research Center derives new cell lines and trains stem cell scientists
5. Rutgers historian puts 50th anniversary of the pill into cultural medicine cabinet
6. Rutgers University Offers Fundamentals of Finance and Accounting Workshop at Mount Laurel, New Jersey Location Aimed at Non-Financial Managers
7. Snowmen Notwithstanding, It's Time To Register For Rutgers' Summer Session
8. Researchers at SUNY Downstate find drug combination may treat traumatic brain injury
9. Do the math, say UCLA researchers
10. MIT researchers discover an unexpected twist in cancer metabolism
11. OHSU researchers able to determine brain maturity through analyzing MRI scans
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/18/2014)... New York (PRWEB) September 18, 2014 ... lawsuits ( http://www.xareltolawsuitcenter.com ) currently pending in Pennsylvania’s ... have all claims filed on behalf of out-of-state ... motions filed on September 11th, the defendants maintain ... claims contained in the lawsuits have no connection ...
(Date:9/18/2014)... 18, 2014 Memorial Cardiac and ... this week by performing the first ever, adult heart ... Network for Organ Sharing) approval to launch the adult ... only two programs in South Florida. , The ... Enrique Gongora, Medical Director of the Adult Heart ...
(Date:9/18/2014)... people become more physically vulnerable during bereavement, new research ... during bereavement changes with age, British researchers say. As ... likely to have weakened immune systems and develop infections, ... months after loss, we can suffer from reduced neutrophil ... blood cell and as such are essential at combating ...
(Date:9/18/2014)... September 18, 2014 One of the ... medical transport industry, ShandsCair Flight Program’s new ... Inc . (AHI) at the Air Medical Transport Conference ... delivered and placed into service ShandsCair EC155 and the ... be displayed at AMTC highlight Airbus Helicopters broad, industry ...
(Date:9/18/2014)... 18, 2014 (HealthDay News) -- Daily supplements of selenium ... the development of age-related cataracts among men, a new ... one or both could help prevent cataracts. To investigate ... and Harvard Medical School in Boston, and his colleagues ... and vitamin E. The trial was initially designed to ...
Breaking Medicine News(10 mins):Health News:Xarelto Lawsuit Defendants Seek to Have Pennsylvania Claims Filed by Out-of-State Plaintiffs Dismissed, Bernstein Liebhard LLP Reports 2Health News:Xarelto Lawsuit Defendants Seek to Have Pennsylvania Claims Filed by Out-of-State Plaintiffs Dismissed, Bernstein Liebhard LLP Reports 3Health News:Memorial Cardiac & Vascular Institute Performs First Adult Heart Transplant in Broward County 2Health News:Memorial Cardiac & Vascular Institute Performs First Adult Heart Transplant in Broward County 3Health News:Memorial Cardiac & Vascular Institute Performs First Adult Heart Transplant in Broward County 4Health News:Grief Can Weigh on Immune System in Older Folks, Study Says 2Health News:Airbus Helicopters Inc. Features Industry-leading Models at AMTC 2Health News:Airbus Helicopters Inc. Features Industry-leading Models at AMTC 3Health News:Airbus Helicopters Inc. Features Industry-leading Models at AMTC 4Health News:Vitamin E, Selenium Supplements Don't Seem to Prevent Cataracts 2
... ... to Sonitor’s Ultrasound RTLS Technology Platform strengthen further the technology’s position as the ... ... Sonitor Technologies, the world leader in ultrasound-based real time locating systems for hospitals ...
... ... ... , ... , , , ...
... patients who regularly received massages averaging 14 minutes or more ... over four weeks, according to results of a study reported ... Society. In the study, sponsored by the National Cancer ... program to provide massage to patients at home. The multi-ethnic ...
... The introduction of prostate-specific antigen (PSA) testing as a screening ... beginning of the 1990s drastically increased the detection of PCa. ... men with PCa. To assess the risk of suicide among ... study was carried out in Sweden. The results are published ...
... Copenhagen, led by postdoc Luke Holman of the Center for ... B , published on the 24 February 2010, that ant ... Often, an ant colony has more than one queen. Multiple ... increasing the chance the colony will survive the hazardous first ...
... ... wristbands market with line of ready-to-ship LaserBand® products that can be instantly priced and ... ... in providing a complete range of printed products and services, today announced the launch ...
Cached Medicine News:Health News:Sonitor Technologies Announces New Staff Tag and Battery Powered Ultrasound Receiver 2Health News:Catholic Charities USA Calls for Affordable and Accessible Healthcare for All 2Health News:Catholic Charities USA Calls for Affordable and Accessible Healthcare for All 3Health News:Family members reduce stress in advanced cancer patients with 14 minute massages 2Health News:Plotting and treachery in ant royal families 2Health News:My1Stop.com Expands Into Medical Wristbands Market with Patented LaserBand Printable Wristbands 2Health News:My1Stop.com Expands Into Medical Wristbands Market with Patented LaserBand Printable Wristbands 3
(Date:9/18/2014)... 18, 2014 MiMedx Group, Inc. (NASDAQ: ... and marketer of patent protected regenerative biomaterials and ... that it has entered into a distribution agreement ... provide its dehydrated human amnion/chorion membrane ("dHACM") allograft ... on a private label basis. The ...
(Date:9/18/2014)... DIEGO , Sept. 18, 2014  Halozyme ... announced that the U.S. Food and Drug Administration ... enrollment and dosing of PEGPH20 in SWOG,s ongoing ... designed to evaluate Halozyme,s investigational drug PEGPH20 (PEGylated ... chemotherapy (mFOLFIRINOX) in patients with metastatic pancreatic adenocarcinoma.  ...
(Date:9/18/2014)... , Sept. 18, 2014 Relmada Therapeutics, ... for the treatment of chronic pain, announced today that ... to the position of  Senior Director of Clinical Development. ... Mr. James has established and led successful global clinical ... , to facilitate the clinical development of numerous ...
Breaking Medicine Technology:MiMedx Signs Distribution Agreement With Zimmer 2MiMedx Signs Distribution Agreement With Zimmer 3SWOG To Resume Clinical Trial Of Halozyme's PEGPH20 In Combination With Modified FOLFIRINOX For Advanced Pancreatic Cancer 2SWOG To Resume Clinical Trial Of Halozyme's PEGPH20 In Combination With Modified FOLFIRINOX For Advanced Pancreatic Cancer 3SWOG To Resume Clinical Trial Of Halozyme's PEGPH20 In Combination With Modified FOLFIRINOX For Advanced Pancreatic Cancer 4Relmada Therapeutics, Inc. Appoints Christopher W. James As Senior Director of Clinical Development 2
... ... ... ... ...
... ... ... ... ...
Cached Medicine Technology:Sensitech's Groundbreaking TempTale(R)4 USB Dry Ice Temperature Monitor Provides Fast, Simple, Efficient Cold Chain Visibility 2Sensitech's Groundbreaking TempTale(R)4 USB Dry Ice Temperature Monitor Provides Fast, Simple, Efficient Cold Chain Visibility 3Sensitech's Groundbreaking TempTale(R)4 USB Dry Ice Temperature Monitor Provides Fast, Simple, Efficient Cold Chain Visibility 4Sensitech's Groundbreaking TempTale(R)4 USB Dry Ice Temperature Monitor Provides Fast, Simple, Efficient Cold Chain Visibility 5China Nepstar Chain Drugstore Reports Fourth Quarter and Fiscal Year 2009 Financial Results 2China Nepstar Chain Drugstore Reports Fourth Quarter and Fiscal Year 2009 Financial Results 3China Nepstar Chain Drugstore Reports Fourth Quarter and Fiscal Year 2009 Financial Results 4China Nepstar Chain Drugstore Reports Fourth Quarter and Fiscal Year 2009 Financial Results 5China Nepstar Chain Drugstore Reports Fourth Quarter and Fiscal Year 2009 Financial Results 6China Nepstar Chain Drugstore Reports Fourth Quarter and Fiscal Year 2009 Financial Results 7China Nepstar Chain Drugstore Reports Fourth Quarter and Fiscal Year 2009 Financial Results 8China Nepstar Chain Drugstore Reports Fourth Quarter and Fiscal Year 2009 Financial Results 9China Nepstar Chain Drugstore Reports Fourth Quarter and Fiscal Year 2009 Financial Results 10China Nepstar Chain Drugstore Reports Fourth Quarter and Fiscal Year 2009 Financial Results 11China Nepstar Chain Drugstore Reports Fourth Quarter and Fiscal Year 2009 Financial Results 12China Nepstar Chain Drugstore Reports Fourth Quarter and Fiscal Year 2009 Financial Results 13China Nepstar Chain Drugstore Reports Fourth Quarter and Fiscal Year 2009 Financial Results 14China Nepstar Chain Drugstore Reports Fourth Quarter and Fiscal Year 2009 Financial Results 15China Nepstar Chain Drugstore Reports Fourth Quarter and Fiscal Year 2009 Financial Results 16China Nepstar Chain Drugstore Reports Fourth Quarter and Fiscal Year 2009 Financial Results 17China Nepstar Chain Drugstore Reports Fourth Quarter and Fiscal Year 2009 Financial Results 18China Nepstar Chain Drugstore Reports Fourth Quarter and Fiscal Year 2009 Financial Results 19China Nepstar Chain Drugstore Reports Fourth Quarter and Fiscal Year 2009 Financial Results 20China Nepstar Chain Drugstore Reports Fourth Quarter and Fiscal Year 2009 Financial Results 21China Nepstar Chain Drugstore Reports Fourth Quarter and Fiscal Year 2009 Financial Results 22China Nepstar Chain Drugstore Reports Fourth Quarter and Fiscal Year 2009 Financial Results 23China Nepstar Chain Drugstore Reports Fourth Quarter and Fiscal Year 2009 Financial Results 24China Nepstar Chain Drugstore Reports Fourth Quarter and Fiscal Year 2009 Financial Results 25China Nepstar Chain Drugstore Reports Fourth Quarter and Fiscal Year 2009 Financial Results 26China Nepstar Chain Drugstore Reports Fourth Quarter and Fiscal Year 2009 Financial Results 27
The Guidant Fineline II Sterox Atrial J is a steroid-eluting pacing lead designed for permanent implantation for either atrial or ventricular applications....
The VascoTip J 9/60 PU is a unipolar tined, J-preformed permanent pacing lead. Due to advanced technology, VascoTip J 9/60 PU M is compatible to all pacemaker-cavities with the size of IS-1 (3.2 mm),...
VascoTip is a unipolar tined permanent pacing lead. Due to advanced technology, VascoTip 9/60 M is compatible to all pacemaker-cavities with the size of IS-1 (3.2 mm), 5 mm, 6 mm....
VascoTip is a unipolar tined permanent pacing lead. Due to advanced technology, VascoTip 9/60 M is compatible to all pacemaker-cavities with the size of IS-1 (3.2 mm), 5 mm, 6 mm....
Medicine Products: