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Rutgers biomaterial debuts in clinical trials of new stent
Date:10/18/2007

New Brunswick, N.J. A revolutionary, new biomaterial, developed at the New Jersey Center for Biomaterials (NJCBM) at Rutgers University, has moved from the lab bench to field testing in record time. This achievement, a product of a breakthrough methodology in biomaterials discovery, is the enabling technology behind a coronary stent undergoing its first-in-human clinical trial in Germany and in Brazil.

Stents are tiny tubes inserted into diseased arteries to keep them open. The stent being tested, designed by REVA Medical Inc. of San Diego, is intended to act as a temporary scaffold to support the blood vessel during the healing process and maintain blood flow. It subsequently dissolves, leaving the patient free of any permanent implant.

Rutgers Joachim Kohn is reporting on his new combinatorial biomaterials discovery process and the promise it holds for the medical device industry during TCT 2007 (Transcatheter Cardiovascular Therapeutics), the world's premier conference on interventional cardiology, which begins Saturday, Oct. 20 in Washington, D.C. Also reporting at the conference, Dr. Eberhard Grube of the HELIOS Heart Center in Germany describes the initial clinical experience from the RESORB trial that is evaluating the stents safety in approximately 30 patients at multiple sites in Germany and Brazil.

Fully degradable coronary stents have been explored for more than 20 years. But, according to Kohn, no clinically useful products could be developed, in part, because of the lack of polymers that could meet the extremely demanding performance requirements. Kohn and his team addressed this problem by developing a library of degradable polymers comprising 10,000 theoretically possible compositions and applying combinatorial methods to identify the best possible biomaterial. The resulting material was selected for use in combination with REVAs novel stent design.

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Contact: Joseph Blumberg
blumberg@ur.rutgers.edu
732-932-7084 x652
Rutgers, the State University of New Jersey
Source:Eurekalert

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